Edin Mujagić
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View article: External validation of PreOpNet to predict 30-day mortality after major non-cardiac surgery using digital electrocardiogram
External validation of PreOpNet to predict 30-day mortality after major non-cardiac surgery using digital electrocardiogram Open
PreOpNet is a novel deep-learning algorithm using 12-lead digital electrocardiogram (ECG) for preoperative risk assessment of all-cause death and major adverse cardiac events (MACE) within 30 days. Its performance in European high-risk pat…
View article: Incidence and Risk Factors of Surgical Site Infections in Vascular Surgical Procedures of the Groin
Incidence and Risk Factors of Surgical Site Infections in Vascular Surgical Procedures of the Groin Open
Background The reported incidence of surgical site infections (SSI) in vascular surgery procedures in the groin varies from 8% to a staggering 30%. SSI represent a major burden in postoperative care, cause hospital readmissions and reopera…
View article: Editor's Choice – Peri-operative Mortality and Morbidity of Complex Abdominal Aortic Aneurysm Repair in Switzerland: A Swissvasc Report
Editor's Choice – Peri-operative Mortality and Morbidity of Complex Abdominal Aortic Aneurysm Repair in Switzerland: A Swissvasc Report Open
Comparable 30 day mortality and morbidity rates were found between OAR and F/B-EVAR for cAAA in Switzerland; lack of centralisation was also highlighted. Organ specific complications driving death were renal failure, intestinal ischaemia, …
View article: Co-Delivery of Recombinant Super-Affinity VEGF and PDGF-BB Accelerates Diabetic Wound Healing by Improving Angiogenesis, Arteriogenesis and Blood Flow
Co-Delivery of Recombinant Super-Affinity VEGF and PDGF-BB Accelerates Diabetic Wound Healing by Improving Angiogenesis, Arteriogenesis and Blood Flow Open
Background Diabetic ulcers are characterized by local ischemia, usually without macroangiopathy. We have previously found that the combination of VEGF and PDGF-BB in a fibrin matrix is effective in stimulating arterial growth to diabetic w…
View article: Free Flaps in Patients with Advanced Arteriosclerosis of the Tibial Vessels: Mini Vein Graft to the Peroneal Artery
Free Flaps in Patients with Advanced Arteriosclerosis of the Tibial Vessels: Mini Vein Graft to the Peroneal Artery Open
Summary: Lower extremity reconstruction with free flaps in patients with only peroneal artery runoff remains a challenge. Here, we present a novel technique for reconstruction of medial defects in the distal leg using a medial approach to …
View article: Prediction of perioperative myocardial infarction/injury in high-risk patients after noncardiac surgery
Prediction of perioperative myocardial infarction/injury in high-risk patients after noncardiac surgery Open
Aims Perioperative myocardial infarction/injury (PMI) is a surprisingly common yet difficult-to-predict cardiac complication in patients undergoing noncardiac surgery. We aimed to assess the incremental value of preoperative cardiac tropon…
View article: A Novel Percutaneous Technique for Aorto-Iliac Thrombectomy without the Risk of Embolization
A Novel Percutaneous Technique for Aorto-Iliac Thrombectomy without the Risk of Embolization Open
Classic surgical thrombectomy of the aorta and iliac arteries through an incision in the groin vessels harbors the risk of embolization to the viscero-renal as well as hypogastric arteries, while percutaneous endovascular thrombectomy tech…
View article: Embosafe – A Novel Percutaneous Technique for Aorto-Iliac Thrombectomy without the Risk of Embolization
Embosafe – A Novel Percutaneous Technique for Aorto-Iliac Thrombectomy without the Risk of Embolization Open
Background Aortoiliac thrombectomies have become more common during the Covid-19 pandemic. Classic surgical thrombectomy of the aorta and iliac arteries through an incision in the groin vessels harbours the risk of embolization to the visc…
View article: Long-term outcomes of perioperative myocardial infarction/injury after non-cardiac surgery
Long-term outcomes of perioperative myocardial infarction/injury after non-cardiac surgery Open
Aims Perioperative myocardial infarction/injury (PMI) following non-cardiac surgery is a frequent cardiac complication. Better understanding of the underlying aetiologies and outcomes is urgently needed. Methods and results Aetiologies of …
View article: Renal failure: a non-cardiac source of high sensitivity cardiac troponin T
Renal failure: a non-cardiac source of high sensitivity cardiac troponin T Open
Background Circulating high sensitivity cardiac troponin T (hs-cTnT) levels are frequently elevated in patients with end-stage renal disease (ESRD). The underlying pathophysiology is largely unknown. Currently, accumulation of hs-cTnT due …
View article: Therapeutic arteriogenesis by factor-decorated fibrin matrices promotes wound healing in diabetic mice
Therapeutic arteriogenesis by factor-decorated fibrin matrices promotes wound healing in diabetic mice Open
Chronic wounds in type-2 diabetic patients present areas of severe local skin ischemia despite mostly normal blood flow in deeper large arteries. Therefore, restoration of blood perfusion requires the opening of arterial connections from t…
View article: Temporary Extracorporeal Femoro-Femoral Crossover Bypass to Treat Acute Limb Ischemia due to Occlusive Femoral Transaortic Microaxial Left Ventricular Assist Device – A Novel Technique and Case Series
Temporary Extracorporeal Femoro-Femoral Crossover Bypass to Treat Acute Limb Ischemia due to Occlusive Femoral Transaortic Microaxial Left Ventricular Assist Device – A Novel Technique and Case Series Open
This is the first case series reporting on this novel technique. We demonstrated that the percutaneous creation of an extracorporeal crossover bypass is feasible, safe and effective and should therefore be promoted.
View article: The Role of HbA1c as a Positive Perioperative Predictor of Surgical Site and Other Postoperative Infections: An Explorative Analysis in Patients Undergoing Minor to Major Surgery
The Role of HbA1c as a Positive Perioperative Predictor of Surgical Site and Other Postoperative Infections: An Explorative Analysis in Patients Undergoing Minor to Major Surgery Open
Background Patients with diabetes mellitus type 2 (DM2) inhere impaired peripheral insulin action leading to higher perioperative morbidity and mortality rates, with hospital‐acquired infections being one important complication. This post …
View article: Cardiovascular Imaging Following Perioperative Myocardial Infarction/Injury
Cardiovascular Imaging Following Perioperative Myocardial Infarction/Injury Open
Background : Patients developing perioperative myocardial infarction/injury(PMI) have high mortality. PMI work-up and therapy remain poorly defined. Methods : In a prospective multicenter study enrolling high-risk patients undergoing major…
View article: Robust Angiogenesis and Arteriogenesis in the Skin of Diabetic Mice by Transient Delivery of Engineered VEGF and PDGF-BB Proteins in Fibrin Hydrogels
Robust Angiogenesis and Arteriogenesis in the Skin of Diabetic Mice by Transient Delivery of Engineered VEGF and PDGF-BB Proteins in Fibrin Hydrogels Open
Non-healing ulcers are a serious complication of diabetes mellitus and a major unmet medical need. A major cause for the lack of healing is the impairment of spontaneous vascularization in the skin, despite mostly normal blood flow in deep…
View article: Simple endovascular thoracic aortic stenting rescues a wrongly deployed frozen elephant trunk during a modified procedure
Simple endovascular thoracic aortic stenting rescues a wrongly deployed frozen elephant trunk during a modified procedure Open
We report a bail out approach of endovascular thoracic aorta repair following incorrect deployment of a modified frozen elephant trunk stent graft into the false lumen. A 76-year-old patient was admitted to our Emergency Department. A comp…
View article: Impact of bodyweight-adjusted antimicrobial prophylaxis on surgical-site infection rates
Impact of bodyweight-adjusted antimicrobial prophylaxis on surgical-site infection rates Open
Background Antimicrobial prophylaxis (AMP) adjustment according to bodyweight to prevent surgical-site infections (SSI) is controversial. The impact of weight-adjusted AMP dosing on SSI rates was investigated here. Methods Results from a f…
View article: Incidence of major adverse cardiac events following non-cardiac surgery
Incidence of major adverse cardiac events following non-cardiac surgery Open
Aims Major adverse cardiac events (MACE) triggered by non-cardiac surgery are prognostically important perioperative complications. However, due to often asymptomatic presentation, the incidence and timing of postoperative MACE are incompl…
View article: Acute aortic dissection with entry tear at the aortic arch: long-term outcome
Acute aortic dissection with entry tear at the aortic arch: long-term outcome Open
OBJECTIVES The goal was to evaluate outcomes after conservative or surgical treatment of acute aortic arch dissections. METHODS Between January 2009 and December 2018, patients with a diagnosis of acute aortic dissection were analysed. Aor…
View article: Temporary extracorporeal femoro-femoral crossover bypass to treat critical limb ischemia due to occlusive femoral transaortic microaxial left ventricular assist device – A novel technique and case series
Temporary extracorporeal femoro-femoral crossover bypass to treat critical limb ischemia due to occlusive femoral transaortic microaxial left ventricular assist device – A novel technique and case series Open
Background The Impella transaortic microaxial left ventricular assist device (MLVAD) is a temporary circulatory support (TCS). It's percutaneous insertion through the common femoral artery (CFA) bears the risk of severe ipsilateral limb is…
View article: Obesity paradox and perioperative myocardial infarction/injury in non-cardiac surgery
Obesity paradox and perioperative myocardial infarction/injury in non-cardiac surgery Open
Obesity class I was associated with a lower incidence of PMI, and obesity in general was associated with a lower all-cause mortality at 365 days.
View article: Therapeutic vascularization in regenerative medicine
Therapeutic vascularization in regenerative medicine Open
Therapeutic angiogenesis, that is, the generation of new vessels by delivery of specific factors, is required both for rapid vascularization of tissue-engineered constructs and to treat ischemic conditions. Vascular endothelial growth fact…