Enrique Aranda
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View article: Definition of lines of treatment in metastatic colorectal cancer: a Delphi consensus
Definition of lines of treatment in metastatic colorectal cancer: a Delphi consensus Open
Purpose Metastatic colorectal cancer (mCRC) presents significant therapeutic challenges, with variability in the definition and classification of lines of treatment (LoTs). This study aimed to achieve consensus among Spanish oncology exper…
View article: Circulating hsa‐miR‐29c‐3p and VEGF‐A levels predict the response to FOLFIRI plus aflibercept in elderly metastatic colorectal cancer patients
Circulating hsa‐miR‐29c‐3p and VEGF‐A levels predict the response to FOLFIRI plus aflibercept in elderly metastatic colorectal cancer patients Open
Background Metastatic colorectal cancer (mCRC) patients who progress on oxaliplatin‐based chemotherapy benefit from second‐line treatment with FOLFIRI plus the antiangiogenic drug aflibercept. However, the absence of validated biomarkers f…
View article: Anxiety, depression, quality of life and the mediating role of psychological flexibility: A study on Spanish cancer patients
Anxiety, depression, quality of life and the mediating role of psychological flexibility: A study on Spanish cancer patients Open
Anxiety, depression and psychological flexibility appear to be correlated with quality of life in cancer patients. However, the mediating role of psychological flexibility between emotional distress and quality of life are unclear. The aim…
View article: Unveilling the potential of liquid biopsy in pancreatic cancer for molecular diagnosis and treatment guidance
Unveilling the potential of liquid biopsy in pancreatic cancer for molecular diagnosis and treatment guidance Open
Pancreatic cancer is usually diagnosed at advance stages leading to a poor prognosis and high mortality rates. Furthermore, only a small fraction of patients are elegible for surgery, which is the only curative treatment available. Obtaini…
View article: Optimization of abdominal wall reconstruction in patients with complex hernia after oncologic surgery: comparative analysis of surgical techniques and prosthetic materials - a systematic review
Optimization of abdominal wall reconstruction in patients with complex hernia after oncologic surgery: comparative analysis of surgical techniques and prosthetic materials - a systematic review Open
Abdominal wall reconstruction (AWR) following oncologic resection presents unique surgical challenges, particularly in patients with complex hernias characterized by large defects, contamination, prior mesh infections, or loss of domain. T…
View article: Real-world management and outcome of patients with pancreatic adenocarcinoma. Results of the Spanish RETUD gastrointestinal registry
Real-world management and outcome of patients with pancreatic adenocarcinoma. Results of the Spanish RETUD gastrointestinal registry Open
Background: Patient registries better reflect real-world management and outcomes of pancreatic cancer (PC) compared with clinical trials. Patients and methods: The main objective was to characterize patterns of care and outcomes in patient…
View article: Prioritizing breast cancer surgeries: insights from the KRONOS SCORE
Prioritizing breast cancer surgeries: insights from the KRONOS SCORE Open
Introduction In many healthcare systems, the time to surgery (TTS) is used as a quality measure in breast cancer (BC) care. Although guidelines suggest that a waiting period of up to four weeks is acceptable, this is often exceeded, potent…
View article: Maintenance with 5-FU/LV-aflibercept after induction with FOLFIRI-aflibercept versus FOLFIRI-aflibercept until progression as second-line treatment in older adults with metastatic colorectal cancer: the AFEMA phase II randomized trial
Maintenance with 5-FU/LV-aflibercept after induction with FOLFIRI-aflibercept versus FOLFIRI-aflibercept until progression as second-line treatment in older adults with metastatic colorectal cancer: the AFEMA phase II randomized trial Open
In older adults, induction with six cycles of FOLFIRI-A plus maintenance with 5-FU/LV-A was non-inferior to FOLFIRI-A until progression. Severe asthenia, SAEs, and treatment-related SAEs were reduced with 5-FU/LV-A maintenance.
View article: Three-year survival follow-up of patients with gastrointestinal cancer treated during the COVID-19 pandemic in Spain: data from the PANDORA-TTD20 study
Three-year survival follow-up of patients with gastrointestinal cancer treated during the COVID-19 pandemic in Spain: data from the PANDORA-TTD20 study Open
Introduction The initial SARS-CoV-2 pandemic wave in Spain in 2020 precipitated significant paradigm shifts in gastrointestinal oncology patient management. This study captures the “Zeitgeist” of this period by analyzing adaptive strategie…
View article: Safety and efficacy of encorafenib–cetuximab combination in BRAF-mutated metastatic colorectal cancer: real-world evidence from the CONFIDENCE Spanish multicenter study
Safety and efficacy of encorafenib–cetuximab combination in BRAF-mutated metastatic colorectal cancer: real-world evidence from the CONFIDENCE Spanish multicenter study Open
Background: Dual blockade therapy encorafenib–cetuximab (EC) was recently established as the standard of care for second- or third-line treatment for BRAFV600E-mutated metastatic colorectal cancer (mCRC) patients based on BEACON phase III …
View article: Sequential RAS mutations evaluation in cell-free DNA of patients with tissue RAS wild-type metastatic colorectal cancer: the PERSEIDA (Cohort 2) study
Sequential RAS mutations evaluation in cell-free DNA of patients with tissue RAS wild-type metastatic colorectal cancer: the PERSEIDA (Cohort 2) study Open
Purpose RAS ( KRAS / NRAS ) mutational status on a tumor biopsy is mandatory to guide the best treatment in metastatic colorectal cancer (mCRC). Determining the RAS mutational status by tumor-tissue biopsy is essential in guiding the optim…
View article: Delphi consensus for the third-line treatment of metastatic colorectal cancer
Delphi consensus for the third-line treatment of metastatic colorectal cancer Open
Purpose The optimal drug regimen and sequence are still unknown for patients with metastatic colorectal cancer (mCRC) who are candidates for third-line (3L) or subsequent treatment. The aim of this study is to know the opinion of experts o…
View article: NeuroPredict: study of the predictive value of ABCB1 genetic polymorphisms and associated clinical factors in chronic chemotherapy-induced peripheral neuropathy (CIPN)
NeuroPredict: study of the predictive value of ABCB1 genetic polymorphisms and associated clinical factors in chronic chemotherapy-induced peripheral neuropathy (CIPN) Open
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common entity (30%–40%) and can significantly limit the quality of life of patients, especially those that persist for more than 6 months after treatment (chronic neuropath…
View article: A new updated prognostic index for patients with brain metastases (BM) treated with palliative whole brain radiotherapy (WBRT) in the era of precision oncology. METASNCore project
A new updated prognostic index for patients with brain metastases (BM) treated with palliative whole brain radiotherapy (WBRT) in the era of precision oncology. METASNCore project Open
Introduction Palliative WBRT is the main treatment for multiple BM. Recent studies report no benefit in survival after WBRT compared to palliative supportive care in patients (pts) with poor prognosis. A new era of systemic treatment strat…
View article: RETRACTED: Sequential RAS mutations evaluation in cell-free DNA of patients with tissue RAS wild- type metastatic colorectal cancer: The PERSEIDA (Cohort 2) Study
RETRACTED: Sequential RAS mutations evaluation in cell-free DNA of patients with tissue RAS wild- type metastatic colorectal cancer: The PERSEIDA (Cohort 2) Study Open
The authors have requested that this preprint be removed from Research Square.
View article: Clinical significance of glycogen synthase kinase 3 (GSK-3) expression and tumor budding grade in colorectal cancer: Implications for targeted therapy
Clinical significance of glycogen synthase kinase 3 (GSK-3) expression and tumor budding grade in colorectal cancer: Implications for targeted therapy Open
our study provides compelling evidence for the clinical significance of GSK-3 expression and TB grade in risk stratification of CRC patients. Moreover, our findings strongly support GSK-3 inhibition as an effective therapy specifically tar…
View article: Ibero-American Consensus Review and Incorporation of New Biomarkers for Clinical Practice in Colorectal Cancer
Ibero-American Consensus Review and Incorporation of New Biomarkers for Clinical Practice in Colorectal Cancer Open
Advances in genomic technologies have significantly improved the management of colorectal cancer (CRC). Several biomarkers have been identified in CRC that enable personalization in the use of biologic agents that have shown to enhance the…
View article: Myocardial work by speckle-tracking echocardiography in pacemaker patients according to pacing site: a prospective study
Myocardial work by speckle-tracking echocardiography in pacemaker patients according to pacing site: a prospective study Open
Funding Acknowledgements Type of funding sources: None. Introduction The optimal lead position for right ventricle (RV) pacing is still a matter of debate. Several studies compared 2D-echocardiography left ventricle ejection fraction (LVEF…
View article: SEOM-GEMCAD-TTD clinical guidelines for the systemic treatment of metastatic colorectal cancer (2022)
SEOM-GEMCAD-TTD clinical guidelines for the systemic treatment of metastatic colorectal cancer (2022) Open
Colorectal cancer (CRC) is the second leading cause of cancer deaths in Spain. Metastatic disease is present in 15–30% of patients at diagnosis and up to 20–50% of those with initially localized disease eventually develop metastases. Recen…