Edit Ábrahám
YOU?
Author Swipe
View article: Diverse triggers, common outcome: Senescence in Fix⁻ <i>Medicago truncatula</i> nodules
Diverse triggers, common outcome: Senescence in Fix⁻ <i>Medicago truncatula</i> nodules Open
Nodule senescence in barrel medic (Medicago truncatula) can occur as a natural, developmentally regulated process or be triggered prematurely by environmental stress or ineffective symbiotic interactions. In this study, we examined five M.…
View article: Functional characterization of a Con7-related transcription factor in <i>Coprinopsis cinerea</i> indicates evolutionary conservation of morphogenetic roles
Functional characterization of a Con7-related transcription factor in <i>Coprinopsis cinerea</i> indicates evolutionary conservation of morphogenetic roles Open
Fruiting bodies of mushroom-forming fungi (Agaricomycetes) exhibit the highest degree of multicellular complexity in fungi, yet the molecular underpinnings of their developmental programs remain incompletely understood. Here, we characteri…
View article: Expression and purification of <scp>E140</scp> protein antigen fragments of <i>Plasmodium vivax</i> and <i>Plasmodium berghei</i> for serological assays
Expression and purification of <span>E140</span> protein antigen fragments of <i>Plasmodium vivax</i> and <i>Plasmodium berghei</i> for serological assays Open
Malaria, a life‐threatening disease caused by Plasmodium parasites, continues to pose a significant global health threat, with nearly 250 million infections and over 600 000 deaths reported annually by the WHO. Fighting malaria is particul…
View article: Experimental horizontal transfer of phage-derived genes to Drosophila confers innate immunity to parasitoids
Experimental horizontal transfer of phage-derived genes to Drosophila confers innate immunity to parasitoids Open
Metazoan parasites have played a major role in shaping innate immunity in animals. Insect hosts and parasitoid wasps are excellent models for illuminating how animal innate immune systems have evolved to neutralize these enemies. One such …
View article: Pore-Forming Toxin-Like Proteins in the Anti-Parasitoid Immune Response of Drosophila
Pore-Forming Toxin-Like Proteins in the Anti-Parasitoid Immune Response of Drosophila Open
Introduction: Species of the ananassae subgroup of Drosophilidae are highly resistant to parasitoid wasp infections. We have previously shown that the genes encoding cytolethal distending toxin B (CdtB) and the apoptosis inducing protein o…
View article: Moesin contributes to heat shock gene response through direct binding to the Med15 subunit of the Mediator complex in the nucleus
Moesin contributes to heat shock gene response through direct binding to the Med15 subunit of the Mediator complex in the nucleus Open
The members of the evolutionary conserved actin-binding Ezrin, Radixin and Moesin (ERM) protein family are involved in numerous key cellular processes in the cytoplasm. In the last decades, ERM proteins, like actin and other cytoskeletal c…
View article: A new regulator of sporulation sheds light on spore morphogenesis and ballistospory in mushroom-forming fungi
A new regulator of sporulation sheds light on spore morphogenesis and ballistospory in mushroom-forming fungi Open
Sporulation is the most widespread means of reproduction and dispersal in fungi. In the Basidiomycota, sexual spores are produced on specialised cells known as basidia, from which they are discharged forcibly by a powered process called ba…
View article: Retracing the horizontal transfer of a novel innate immune factor in<i>Drosophila</i>
Retracing the horizontal transfer of a novel innate immune factor in<i>Drosophila</i> Open
Summary Immune systems are among the most dynamically evolving traits across the tree of life, and long-lived macroparasites play an outsized role in shaping animal immunity. Even without adaptive immunity, insects have evolved potent inna…
View article: Distinct components of nucleoside-modified messenger RNA vaccines cooperate to instruct efficient germinal center responses
Distinct components of nucleoside-modified messenger RNA vaccines cooperate to instruct efficient germinal center responses Open
SUMMARY Nucleoside-modified mRNA vaccines elicit protective antibodies through their ability to promote T follicular helper (Tfh) cells. The lipid nanoparticle (LNP) component of mRNA vaccines possesses inherent adjuvant activity. However,…
View article: mRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies
mRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies Open
The role of CD8+ T cells in SARS-CoV-2 pathogenesis or mRNA-LNP vaccine-induced protection from lethal COVID-19 is unclear. Using mouse-adapted SARS-CoV-2 virus (MA30) in C57BL/6 mice, we show that CD8+ T cells are unnecessary for the intr…
View article: Expression and purification of the receptor‐binding domain of <scp>SARS‐CoV</scp>‐2 spike protein in mammalian cells for immunological assays
Expression and purification of the receptor‐binding domain of <span>SARS‐CoV</span>‐2 spike protein in mammalian cells for immunological assays Open
The receptor‐binding domain (RBD) of the spike glycoprotein of SARS‐CoV‐2 virus mediates the interaction with the host cell and is required for virus internalization. It is, therefore, the primary target of neutralizing antibodies. The rec…
View article: Protein Phosphatase 4 Is Required for Centrobin Function in DNA Damage Repair
Protein Phosphatase 4 Is Required for Centrobin Function in DNA Damage Repair Open
Genome stability in human cells relies on the efficient repair of double-stranded DNA breaks, which is mainly achieved by homologous recombination (HR). Among the regulators of various cellular functions, Protein phosphatase 4 (PP4) plays …
View article: Protein phosphatase 4 is required for Centrobin function in DNA damage repair
Protein phosphatase 4 is required for Centrobin function in DNA damage repair Open
Genome stability in human cells relies on the efficient repair of double-stranded DNA breaks, which is mainly achieved by homologous recombination (HR). Among the regulators of various cellular functions, Protein Phosphatase 4 (PP4) plays …
View article: Evolution of insect innate immunity through domestication of bacterial toxins
Evolution of insect innate immunity through domestication of bacterial toxins Open
Toxin cargo genes are often horizontally transferred by phages between bacterial species and are known to play an important role in the evolution of bacterial pathogenesis. Here, we show how these same genes have been horizontally transfer…
View article: Plk4 Is a Novel Substrate of Protein Phosphatase 5
Plk4 Is a Novel Substrate of Protein Phosphatase 5 Open
The conserved Ser/Thr protein phosphatase 5 (PP5) is involved in the regulation of key cellular processes, including DNA damage repair and cell division in eukaryotes. As a co-chaperone of Hsp90, PP5 has been shown to modulate the maturati…
View article: <scp>GST‐IVTT</scp> pull‐down: a fast and versatile <i>in vitro</i> method for validating and mapping protein–protein interactions
<span>GST‐IVTT</span> pull‐down: a fast and versatile <i>in vitro</i> method for validating and mapping protein–protein interactions Open
Over the past few decades, dozens of in vitro methods have been developed to map, investigate and validate protein–protein interactions. However, most of these approaches are time‐consuming and labour‐intensive or require specialised equip…
View article: STABILON, a Novel Sequence Motif That Enhances the Expression and Accumulation of Intracellular and Secreted Proteins
STABILON, a Novel Sequence Motif That Enhances the Expression and Accumulation of Intracellular and Secreted Proteins Open
The dynamic balance of transcriptional and translational regulation together with degron-controlled proteolysis shapes the ever-changing cellular proteome. While a large variety of degradation signals has been characterized, our knowledge …
View article: Novel perspectives of target-binding by the evolutionarily conserved PP4 phosphatase
Novel perspectives of target-binding by the evolutionarily conserved PP4 phosphatase Open
Protein phosphatase 4 (PP4) is an evolutionarily conserved and essential Ser/Thr phosphatase that regulates cell division, development and DNA repair in eukaryotes. The major form of PP4, present from yeast to human, is the PP4c-R2-R3 hete…
View article: Host-secreted antimicrobial peptide enforces symbiotic selectivity in <i>Medicago truncatula</i>
Host-secreted antimicrobial peptide enforces symbiotic selectivity in <i>Medicago truncatula</i> Open
Significance Nitrogen is a limiting factor for plant growth. Most crops obtain their nitrogen through the use of nitrogen-based fertilizers, which is costly, and also causes environmental pollution. Legumes, however, have the unique abilit…