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View article: Trick or Treat(ment): Should We Still Fear Reperfusion Therapy in Anticoagulated Stroke Patients?—Comparable 90-Day Outcomes in a Propensity-Score-Matched Registry Study
Trick or Treat(ment): Should We Still Fear Reperfusion Therapy in Anticoagulated Stroke Patients?—Comparable 90-Day Outcomes in a Propensity-Score-Matched Registry Study Open
Background: The management of acute ischemic stroke (AIS) in anticoagulated patients presents a clinical challenge, as concerns about safety and efficacy often limit access to recanalization therapies. Despite the widespread use of direct …
View article: Putting DOAC Doubts to Bed(Side): Preliminary Evidence of Comparable Functional Outcomes in Anticoagulated and Non-Anticoagulated Stroke Patients Using Point-of-Care ClotPro® Testing
Putting DOAC Doubts to Bed(Side): Preliminary Evidence of Comparable Functional Outcomes in Anticoagulated and Non-Anticoagulated Stroke Patients Using Point-of-Care ClotPro® Testing Open
Background/Objectives: Direct oral anticoagulants (DOACs) are now the guideline-recommended alternative to vitamin K antagonists (VKAs) for long-term anticoagulation in patients with non-valvular atrial fibrillation. However, accurately as…
View article: Viscoelastic Point-of-Care Testing (ClotPro®) to Guide Intravenous Thrombolysis in Acute Ischemic Stroke Patients on DOACs: Replacing History with Hemostasis in a Proof-of-Concept Study
Viscoelastic Point-of-Care Testing (ClotPro®) to Guide Intravenous Thrombolysis in Acute Ischemic Stroke Patients on DOACs: Replacing History with Hemostasis in a Proof-of-Concept Study Open
Background: Administering intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS) on direct oral anticoagulants (DOACs) remains a clinical challenge. Current guidelines restrict IVT within 48 h of DOAC intake unless ant…
View article: Viscoelastic Point-of-Care Testing (ClotPro®) to Guide Intravenous Thrombolysis in Acute Ischemic Stroke Patients on DOACs: Replacing History with Hemostasis in a Proof-of-Concept Study
Viscoelastic Point-of-Care Testing (ClotPro®) to Guide Intravenous Thrombolysis in Acute Ischemic Stroke Patients on DOACs: Replacing History with Hemostasis in a Proof-of-Concept Study Open
Background: Administering intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS) on direct oral anticoagulants (DOACs) remains a clinical challenge. Current guidelines restrict IVT within 48 hours of DOAC intake unless…
View article: Trick or Treat(ment): Should We Still Fear Reperfusion Therapy in Anticoagulated Stroke Patients?
Trick or Treat(ment): Should We Still Fear Reperfusion Therapy in Anticoagulated Stroke Patients? Open
Background: The management of acute ischemic stroke (AIS) in anticoagulated patients presents a clinical challenge, as concerns about safety and efficacy often limit access to recanalization therapies. Despite the widespread use of direct …
View article: Putting DOAC Doubts to Bed(side): Point-of-Care ClotPro® Testing Confirms Comparable Functional Outcomes in Anticoagulated and Non-Anticoagulated Stroke Patients
Putting DOAC Doubts to Bed(side): Point-of-Care ClotPro® Testing Confirms Comparable Functional Outcomes in Anticoagulated and Non-Anticoagulated Stroke Patients Open
Background Direct oral anticoagulants (DOACs) are now the guideline-recommended alternative to vitamin K antagonists (VKAs) for long-term anticoagulation. However, accurately assessing their impact on ischemic stroke outcomes remains chall…
View article: Shifting Outcomes: Superior Functional Recovery in Embolic Stroke of Undetermined Source Compared to Cardioembolic Stroke
Shifting Outcomes: Superior Functional Recovery in Embolic Stroke of Undetermined Source Compared to Cardioembolic Stroke Open
Background/Objectives: An embolic stroke of undetermined source (ESUS) is a subtype of ischemic stroke characterized by a non-lacunar infarct in the absence of a clearly identifiable embolic source, despite comprehensive diagnostic evaluat…
View article: Pre-Admission Antiplatelet Therapy in Cryptogenic Stroke: A Double-Edged Sword
Pre-Admission Antiplatelet Therapy in Cryptogenic Stroke: A Double-Edged Sword Open
Background: Cryptogenic stroke, a challenging subtype of acute ischemic stroke (AIS), is characterized by the absence of an identifiable etiology despite thorough diagnostic assessment. The role of pre-admission antiplatelet therapy (APT) …
View article: A Match Made Unequal: Impact of Oral Anticoagulants on Stroke Outcomes Following Propensity Score Matching
A Match Made Unequal: Impact of Oral Anticoagulants on Stroke Outcomes Following Propensity Score Matching Open
Background/Objectives: Oral anticoagulants (OACs) are commonly used for stroke prevention in patients with atrial fibrillation (AF), but their impact on long-term outcomes following acute ischemic stroke (AIS) remains uncertain. This study…
View article: Shifting Outcomes: Superior Functional Recovery in Embolic Stroke of Undetermined Source Compared to Cardioembolic Stroke
Shifting Outcomes: Superior Functional Recovery in Embolic Stroke of Undetermined Source Compared to Cardioembolic Stroke Open
Background/Objectives: Embolic Stroke of Undetermined Source (ESUS) is a subtype of ischemic stroke characterized by a non-lacunar infarct in the absence of a clearly identifiable embolic source, despite comprehensive diagnostic evaluation…
View article: Stroke-SCORE: Personalizing Acute Ischemic Stroke Treatment to Improve Patient Outcomes
Stroke-SCORE: Personalizing Acute Ischemic Stroke Treatment to Improve Patient Outcomes Open
Background/Objectives: Acute ischemic stroke (AIS) is a leading cause of disability and mortality worldwide. Despite advances in interventions such as thrombolysis (TL) and mechanical thrombectomy (MT), current treatment protocols remain l…
View article: Pre-Admission Antiplatelet Therapy in Cryptogenic Stroke: A Double-Edged Sword
Pre-Admission Antiplatelet Therapy in Cryptogenic Stroke: A Double-Edged Sword Open
Background/Objectives: Cryptogenic stroke, a challenging subtype of acute ischemic stroke (AIS), is characterized by the absence of an identifiable etiology despite thorough diagnostic assessment. The role of pre-admission antiplatelet the…
View article: Stroke-SCORE: Personalizing Acute Ischemic Stroke Treatment to Improve Patient Outcomes
Stroke-SCORE: Personalizing Acute Ischemic Stroke Treatment to Improve Patient Outcomes Open
Background/Objectives: Acute ischemic stroke (AIS) is a leading cause of disability and mortality worldwide. Despite advances in interventions such as thrombolysis (TL) and mechanical thrombectomy (MT), current treatment protocols remain l…
View article: Beyond Anticoagulation: Limitations of Oral Anticoagulants in Preventing Stroke Recurrence in Atrial Fibrillation
Beyond Anticoagulation: Limitations of Oral Anticoagulants in Preventing Stroke Recurrence in Atrial Fibrillation Open
Background/Objectives: Despite the widespread use of oral anticoagulants (OACs), acute ischemic stroke (AIS) remains a significant risk for patients with atrial fibrillation (AF). The real-world effectiveness of OACs in preventing recurren…
View article: Beyond Anticoagulation: Limitations of Oral Anticoagulants in Preventing Stroke Recurrence in Atrial Fibrillation
Beyond Anticoagulation: Limitations of Oral Anticoagulants in Preventing Stroke Recurrence in Atrial Fibrillation Open
Background/Objectives: Despite the widespread use of oral anticoagulants (OACs), acute ischemic stroke (AIS) remains a significant risk for patients with atrial fibrillation (AF). The real-world effectiveness of OACs in preventing recurren…
View article: Bridging the Gap: Improving Acute Ischemic Stroke Outcomes with Intravenous Thrombolysis Prior to Mechanical Thrombectomy
Bridging the Gap: Improving Acute Ischemic Stroke Outcomes with Intravenous Thrombolysis Prior to Mechanical Thrombectomy Open
Background/Objectives: Current guidelines recommend intravenous thrombolysis (IVT) followed by mechanical thrombectomy (MT) for patients with acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). This combined approach, known…
View article: Bridging the Gap: Improving Acute Ischemic Stroke Outcomes with Intravenous Thrombolysis Prior to Mechanical Thrombectomy
Bridging the Gap: Improving Acute Ischemic Stroke Outcomes with Intravenous Thrombolysis Prior to Mechanical Thrombectomy Open
Background/Objectives: Current guidelines recommend intravenous thrombolysis (IVT) followed by mechanical thrombectomy (MT) for patients with acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). This combined approach, known…
View article: Neurovascular changes of the retina and optic nerve head in episodic migraine
Neurovascular changes of the retina and optic nerve head in episodic migraine Open
Aim: To investigate neurovascular changes; including macular vascular density (VD), thickness of the ganglion cell layer (GCL) and optic nerve head (ONH) parameters in episodic migraine patients. Patients and methods: 80 eyes of 40 episodi…
View article: Differentiation of hemispheric white matter lesions in migraine and multiple sclerosis with similar radiological features using advanced MRI
Differentiation of hemispheric white matter lesions in migraine and multiple sclerosis with similar radiological features using advanced MRI Open
Background and aim White matter hyperintensities (WMHs), presented on T2-weighted or fluid-attenuated inversion recovery magnetic resonance imaging (MRI) sequences, are lesions in the human brain that can be observed in both migraine and m…
View article: Volumetric alteration of brainstem in female migraineurs with and without aura
Volumetric alteration of brainstem in female migraineurs with and without aura Open
Brainstem volume changes in migraine are mainly localized to the medulla and not specific to the presence of aura.
View article: The volume of the thalamus and hippocampus in a right-handed female episodic migraine group
The volume of the thalamus and hippocampus in a right-handed female episodic migraine group Open
Background/aim Migraine is a disabling headache with clinical and radiological complications. The aim of this study was to investigate the volume of the thalamus and hippocampus in migraineurs, the role of white matter lesions (WMLs), and …
View article: The assessment of acute chorioretinal changes due to intensive physical exercise in young adults
The assessment of acute chorioretinal changes due to intensive physical exercise in young adults Open
Purpose There is abundant evidence on the benefits of physical activity on cardiovascular health. However, there are only few data on the acute effects of physical exercise on the retina and choroid. Our aim was the in vivo examination of …
View article: The Impact of Diabetes Mellitus and Admission Hyperglycemia on Clinical Outcomes after Recanalization Therapies for Acute Ischemic Stroke: STAY ALIVE National Prospective Registry
The Impact of Diabetes Mellitus and Admission Hyperglycemia on Clinical Outcomes after Recanalization Therapies for Acute Ischemic Stroke: STAY ALIVE National Prospective Registry Open
It was previously reported that diabetes mellitus (DM) and admission hyperglycemia (aHG) were associated with poor clinical outcomes in patients with acute ischemic stroke (AIS) who were treated with intravenous thrombolysis (IVT) or mecha…
View article: Comparison of the Cardiovascular Effects of Extreme Psychological and Physical Stress Tests in Male Soccer Players
Comparison of the Cardiovascular Effects of Extreme Psychological and Physical Stress Tests in Male Soccer Players Open
Background: The purpose of our study was to compare the physiological effects of extreme physical and psychological stress tests in male soccer players, since these two types of stress apply to athletes with high performance requirements. …
View article: Physiological and Psychological Responses to a Maximal Swimming Exercise Test in Adolescent Elite Athletes
Physiological and Psychological Responses to a Maximal Swimming Exercise Test in Adolescent Elite Athletes Open
Background: Continuously rising performances in elite adolescent athletes requires increasing training loads. This training overload without professional monitoring, could lead to overtraining in these adolescents. Methods: 31 elite adoles…
View article: Comparing Endovascular Treatment Methods in Acute Ischemic Stroke Due to Tandem Occlusion Focusing on Clinical Aspects
Comparing Endovascular Treatment Methods in Acute Ischemic Stroke Due to Tandem Occlusion Focusing on Clinical Aspects Open
Introduction: Acute ischemic strokes (AIS) due to tandem occlusion (TO) of intracranial anterior large vessel and concomitant extracranial internal carotid artery (EICA) are represent in 15–20% of all ischemic strokes. The endovascular tre…
View article: The MCT1 gene Glu490Asp polymorphism (rs1049434)is associated with endurance athlete status, lower blood lactateaccumulation and higher maximum oxygen uptake
The MCT1 gene Glu490Asp polymorphism (rs1049434)is associated with endurance athlete status, lower blood lactateaccumulation and higher maximum oxygen uptake Open
The purpose of this study was to explore the association of the MCT1 gene Glu490Asp polymorphism (rs1049434) with athletic status and performance of endurance athletes. A total of 1,208 Brazilians (318 endurance athletes and 890 non-athlet…
View article: Risk analysis of post-procedural intracranial hemorrhage based on STAY ALIVE Acute Stroke Registry
Risk analysis of post-procedural intracranial hemorrhage based on STAY ALIVE Acute Stroke Registry Open
Although partial recanalization, ASPECT< 6, and poor collaterals were significantly associated with sICH, the only independent predictor was NIHSS ≥15.5 at 24 post stroke hours. This suggests a careful evaluation of patients with worsening…