Edith Bogner
YOU?
Author Swipe
View article: Health economic simulation modeling of an AI-enabled clinical decision support system for coronary revascularization
Health economic simulation modeling of an AI-enabled clinical decision support system for coronary revascularization Open
Importance Coronary revascularization decision-making can be challenging. While artificial intelligence (AI) models have been developed to support this decision-making, health economic evaluation of such models has been rare. Objective To …
View article: Short-term and long-term outcome prediction for patients with coronary artery disease using machine learning and comprehensive multi-center patient data
Short-term and long-term outcome prediction for patients with coronary artery disease using machine learning and comprehensive multi-center patient data Open
Background Revascularization decision-making for patients with coronary artery disease (CAD) can benefit from accurate patient outcome prediction. While previous studies have employed data-driven methods including machine learning (ML) to …
View article: Germline genetic factors influence the outcome of interferon-α therapy in polycythemia vera
Germline genetic factors influence the outcome of interferon-α therapy in polycythemia vera Open
Interferon-α (IFN-α)–based treatments can induce hematologic and molecular responses (HRs and MRs, respectively) in polycythemia vera (PV); however, patients do not respond equally. Germline genetic factors have been implicated in differen…
View article: Myelomonocytic Skewing In Vitro Discriminates Subgroups of Patients with Myelofibrosis with A Different Phenotype, A Different Mutational Profile and Different Prognosis
Myelomonocytic Skewing In Vitro Discriminates Subgroups of Patients with Myelofibrosis with A Different Phenotype, A Different Mutational Profile and Different Prognosis Open
Normal hematopoietic function is maintained by a well-controlled balance of myelomonocytic, megaerythroid and lymphoid progenitor cell populations which may be skewed during pathologic conditions. Using semisolid in vitro cultures supporti…
View article: PF659 MYELOMONOCYTIC SKEWING IN VITRO DISCRIMINATES SUBGROUPS OF PATIENTS WITH MYELOFIBROSIS WITH A DIFFERENT PHENOTYPE, A DIFFERENT GENOTYPE AND DIFFERENT PROGNOSIS
PF659 MYELOMONOCYTIC SKEWING IN VITRO DISCRIMINATES SUBGROUPS OF PATIENTS WITH MYELOFIBROSIS WITH A DIFFERENT PHENOTYPE, A DIFFERENT GENOTYPE AND DIFFERENT PROGNOSIS Open
Background: Normal hematopoietic function is maintained by a well controlled balance of myelomonocytic, megaerythroid and lymphoid progenitor cell populations. This balance may be skewed during pathologic conditions such as hematological m…
View article: Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms
Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms Open
Ph-negative myeloproliferative neoplasms (MPNs) are hematological cancers that can be subdivided into entities with distinct clinical features. Somatic mutations in JAK2, CALR, and MPL have been described as drivers of the disease, togethe…
View article: Heterologous protein production using euchromatin-containing expression vectors in mammalian cells
Heterologous protein production using euchromatin-containing expression vectors in mammalian cells Open
Upon stable cell line generation, chromosomal integration site of the vector DNA has a major impact on transgene expression. Here we apply an active gene environment, rather than specified genetic elements, in expression vectors used for r…
View article: Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis
Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis Open
STAT3 is considered to play an oncogenic role in several malignancies including lung cancer; consequently, targeting STAT3 is currently proposed as therapeutic intervention. Here we demonstrate that STAT3 plays an unexpected tumour-suppres…