Findings provide additional evidence for the role of IL-6 and TNF-α in perinatal depressive symptoms. Anhedonia symptoms and third-trimester inflammation may be particularly important. Future work focusing on dimensions of depressive symptoms and inflammatory processes across the perinatal period is key to elucidating specific temporal associations. Further investigation of how changes in inflammation across pregnancy relate to specific types of depressive symptoms could inform and improve perinatal care and inter…

Abstract Prenatal exposure to heightened maternal inflammation has been associated with adverse neurodevelopmental outcomes, including atypical brain maturation and psychiatric illness. In mothers experiencing socioeconomic disadvantage, immune activation can be a product of the chronic stress inherent to such environmental hardship. While growing preclinical and clinical evidence has shown links between altered neonatal brain development and increased inflammatory states in utero, the potential mechanism by which…

Importance Metabolic syndrome (MetS) is a common health condition that predisposes individuals to cardiovascular disease (CVD) and disproportionately affects Black and other racially and ethnically minoritized people. Concurrently, Black individuals also report more exposure to racial discrimination compared with White individuals; however, the role of discrimination in the development of MetS over time and associated mediators in these pathways remain underexplored. Objective To evaluate the association between r…

In conclusion, hepatitis A is associated with a substantial economic burden among privately insured individuals in the US.

<title>Abstract</title> Maternal stress and depression during pregnancy and the first year of the infant’s life affect a large percentage of mothers. Maternal stress and depression have been associated with adverse fetal and childhood outcomes as well as differential child DNA methylation (DNAm). However, the biological mechanisms connecting maternal stress and depression to poor health outcomes in children are still largely unknown. Here we aim to determine whether prenatal stress and depression are associated wi…