Elizabeth R. Gavis
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View article: Patterns of Mitochondrial ATP Predict Tissue Folding
Patterns of Mitochondrial ATP Predict Tissue Folding Open
The construction of complex tissue shapes during embryonic development results from spatial patterns of gene expression and mechanical forces fueled by chemical energy from ATP hydrolysis. We find that chemical energy is similarly patterne…
View article: Geometric Effects in Large Scale Intracellular Flows
Geometric Effects in Large Scale Intracellular Flows Open
This work probes the role of cell geometry in orienting self-organized fluid flows in the late-stage oocyte. Recent theoretical work has shown that a model, which relies only on hydrodynamic interactions of flexible, cortically anchored mi…
View article: Geometric Effects in Large Scale Intracellular Flows
Geometric Effects in Large Scale Intracellular Flows Open
This work probes the role of cell geometry in orienting self-organized fluid flows in the late stage Drosophila oocyte. Recent theoretical work has shown that a model, which relies only on hydrodynamic interactions of flexible, cortically …
View article: Smaug regulates germ plasm assembly and primordial germ cell number in Drosophila embryos
Smaug regulates germ plasm assembly and primordial germ cell number in Drosophila embryos Open
During Drosophila oogenesis, the Oskar (OSK) RNA binding protein (RBP) determines the amount of germ plasm that assembles at the posterior pole of the oocyte. Here, we identify mechanisms that subsequently regulate germ plasm assembly in t…
View article: Localization of oskar mRNA by agglomeration in ribonucleoprotein granules
Localization of oskar mRNA by agglomeration in ribonucleoprotein granules Open
Localization of oskar mRNA to the posterior of the Drosophila oocyte is essential for abdominal patterning and germline development. oskar localization is a multi-step process involving temporally and mechanistically distinct transport mod…
View article: The translational repressor Glorund uses interchangeable RNA recognition domains to recognize Drosophila <i>nanos</i>
The translational repressor Glorund uses interchangeable RNA recognition domains to recognize Drosophila <i>nanos</i> Open
The Drosophila melanogaster protein Glorund (Glo) represses nanos (nos) translation and uses its quasi-RNA recognition motifs (qRRMs) to recognize both G-tract and structured UA-rich motifs within the nos translational control element (TCE…
View article: H/ACA snRNP–dependent ribosome biogenesis regulates translation of polyglutamine proteins
H/ACA snRNP–dependent ribosome biogenesis regulates translation of polyglutamine proteins Open
Stem cells in many systems, including Drosophila germline stem cells (GSCs), increase ribosome biogenesis and translation during terminal differentiation. Here, we show that the H/ACA small nuclear ribonucleoprotein (snRNP) complex that pr…
View article: Plasticity of Drosophila germ granules during germ cell development
Plasticity of Drosophila germ granules during germ cell development Open
Compartmentalization of RNAs and proteins into membraneless structures called granules is a ubiquitous mechanism for organizing and regulating cohorts of RNAs. Germ granules are ribonucleoprotein (RNP) assemblies required for germline deve…
View article: Smaug regulates germ plasm synthesis and primordial germ cell number in Drosophila embryos by repressing the<i>oskar</i>and<i>bruno 1</i>mRNAs
Smaug regulates germ plasm synthesis and primordial germ cell number in Drosophila embryos by repressing the<i>oskar</i>and<i>bruno 1</i>mRNAs Open
During Drosophila oogenesis, the Oskar (OSK) RNA-binding protein (RBP) determines the amount of germ plasm that assembles at the posterior pole of the oocyte. Here we identify the mechanisms that regulate the osk mRNA in the early embryo. …
View article: <i>Drosophila</i> FMRP controls miR-276-mediated regulation of <i>nejire</i> mRNA for space-filling dendrite development
<i>Drosophila</i> FMRP controls miR-276-mediated regulation of <i>nejire</i> mRNA for space-filling dendrite development Open
MicroRNAs are enriched in neurons and play important roles in dendritic spine development and synaptic plasticity. MicroRNA activity is controlled by a wide range of RNA-binding proteins. FMRP, a highly conserved RNA-binding protein, has b…
View article: Pseudouridine-dependent ribosome biogenesis regulates translation of polyglutamine proteins during <i>Drosophila</i> oogenesis
Pseudouridine-dependent ribosome biogenesis regulates translation of polyglutamine proteins during <i>Drosophila</i> oogenesis Open
Stem cells in many systems, including Drosophila germline stem cells (GSCs), increase ribosome biogenesis and translation during terminal differentiation. Here, we show that pseudouridylation of ribosomal RNA (rRNA) mediated by the H/ACA b…
View article: The <i>Drosophila</i> hnRNP F/H homolog Glorund recruits dFMRP to inhibit <i>nanos</i> translation elongation
The <i>Drosophila</i> hnRNP F/H homolog Glorund recruits dFMRP to inhibit <i>nanos</i> translation elongation Open
Translational control of maternal mRNAs generates spatial and temporal patterns of protein expression necessary to begin animal development. Translational repression of unlocalized nanos (nos) mRNA in late-stage Drosophila oocytes by the h…
View article: The <i>Drosophila</i> fragile X mental retardation protein modulates the neuronal cytoskeleton to limit dendritic arborization
The <i>Drosophila</i> fragile X mental retardation protein modulates the neuronal cytoskeleton to limit dendritic arborization Open
Dendritic arbor development is a complex, highly regulated process. Post-transcriptional regulation mediated by RNA-binding proteins plays an important role in neuronal dendrite morphogenesis by delivering on-site, on-demand protein synthe…
View article: Overlapping and distinct cis-acting requirements for <i>oskar</i> mRNA localization pathways
Overlapping and distinct cis-acting requirements for <i>oskar</i> mRNA localization pathways Open
Localization of oskar mRNA to the posterior of the Drosophila oocyte is essential for abdominal patterning and germline development. oskar localization is a multi-step process involving temporally and mechanistically distinct transport mod…
View article: The ELAV/Hu protein Found in neurons regulates cytoskeletal and ECM adhesion inputs for space-filling dendrite growth
The ELAV/Hu protein Found in neurons regulates cytoskeletal and ECM adhesion inputs for space-filling dendrite growth Open
Dendritic arbor morphology influences how neurons receive and integrate extracellular signals. We show that the ELAV/Hu family RNA-binding protein Found in neurons (Fne) is required for space-filling dendrite growth to generate highly bran…
View article: Compartmentalized oskar degradation in the germ plasm safeguards germline development
Compartmentalized oskar degradation in the germ plasm safeguards germline development Open
Partitioning of mRNAs into ribonucleoprotein (RNP) granules supports diverse regulatory programs within the crowded cytoplasm. At least two types of RNP granules populate the germ plasm, a cytoplasmic domain at the posterior of the Drosoph…
View article: Distinct <i>cis</i>-acting elements mediate targeting and clustering of <i>Drosophila</i> polar granule mRNAs
Distinct <i>cis</i>-acting elements mediate targeting and clustering of <i>Drosophila</i> polar granule mRNAs Open
Specification and development of Drosophila germ cells depend on molecular determinants within the germ plasm, a specialized cytoplasmic domain at the posterior of the embryo. Localization of numerous mRNAs to the germ plasm occurs by thei…
View article: Germ Cell-less Promotes Centrosome Segregation to Induce Germ Cell Formation
Germ Cell-less Promotes Centrosome Segregation to Induce Germ Cell Formation Open
The primordial germ cells (PGCs) specified during embryogenesis serve as progenitors to the adult germline stem cells. In Drosophila, the proper specification and formation of PGCs require both centrosomes and germ plasm, which contains th…
View article: Removal of <em>Drosophila</em> Muscle Tissue from Larval Fillets for Immunofluorescence Analysis of Sensory Neurons and Epidermal Cells
Removal of <em>Drosophila</em> Muscle Tissue from Larval Fillets for Immunofluorescence Analysis of Sensory Neurons and Epidermal Cells Open
Drosophila larval dendritic arborization (da) neurons are a popular model for investigating mechanisms of neuronal morphogenesis. Da neurons develop in communication with the epidermal cells they innervate and thus their analysis benefits …
View article: bicoid mRNA localises to the Drosophila oocyte anterior by random Dynein-mediated transport and anchoring
bicoid mRNA localises to the Drosophila oocyte anterior by random Dynein-mediated transport and anchoring Open
bicoid mRNA localises to the Drosophila oocyte anterior from stage 9 of oogenesis onwards to provide a local source for Bicoid protein for embryonic patterning. Live imaging at stage 9 reveals that bicoid mRNA particles undergo rapid Dynei…