Édith Heard
YOU?
Author Swipe
Escape from X inactivation is directly modulated by Xist noncoding RNA Open
In placental XX females, one X chromosome is silenced during a narrow developmental time window by X-chromosome inactivation, which is mediated by Xist noncoding RNA. Although most X-linked genes are silenced during X-chromosome inactivati…
View article: High-quality mouse reference genomes reveal the structural complexity of the murine protein-coding landscape
High-quality mouse reference genomes reveal the structural complexity of the murine protein-coding landscape Open
We present a collection of 17 high-quality long-read inbred mouse strain genomes with complete annotation (contig N50s of 0.8-33.9 Mbp). This collection includes 12 widely used classical laboratory strains and 5 wild-derived strains. We ha…
View article: Genetic and chromatin regulation of Pvt1 monoallelic expression
Genetic and chromatin regulation of Pvt1 monoallelic expression Open
While most genes are equivalently expressed on both alleles, genes with random monoallelic expression (RME) stably maintain expression from only one allele, but the mechanisms and consequences of RME remain unclear. We performed allele-spe…
View article: The mouse pangenome reveals the structural complexity of the murine protein-coding landscape
The mouse pangenome reveals the structural complexity of the murine protein-coding landscape Open
We present the first mouse pangenome consisting of 17 high-quality inbred mouse strain genomes with complete annotation. This collection includes 12 widely used classical laboratory strains and 5 wild-derived strains. We have fully resolve…
Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage Open
The Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the Y Sry- chromosome and thus increas…
Escape from X inactivation is directly modulated by levels of Xist non-coding RNA Open
In placental females, one copy of the two X chromosomes is largely silenced during a narrow developmental time window, in a process mediated by the non-coding RNA Xist 1 . Here, we demonstrate that Xist can initiate X-chromosome inactivati…
Transcriptional perturbation of LINE-1 elements reveals their <i>cis</i> -regulatory potential Open
Long interspersed element-1 (LINE-1 or L1) retrotransposons constitute the largest transposable element (TE) family in mammalian genomes and contribute prominently to inter- and intra-individual genetic variation. Although most L1 elements…
Epigenetics and Cellular Memory Open
How is the information contained in our genes read, memorized and interpreted? What mechanisms control gene expression in an individual or across generations? The understanding of these mechanisms is crucial to knowledge on life forms. Epi…
Epigenetics and Cellular Memory Open
Mr Administrator,My dear colleagues,My friends, agapimeni mou fili, The creation of a Chair of Epigenetics and Cellular Memory is the beginning of a new adventure, both for the Collège de France and for myself. I firstly feel highly honour…
View article: Strategies to decrease inequalities in cancer therapeutics, care and prevention
Strategies to decrease inequalities in cancer therapeutics, care and prevention Open
Analyses of inequalities related to prevention and cancer therapeutics/care show disparities between countries with different economic standing, and within countries with high Gross Domestic Product. The development of basic technological …
Four-Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage Open
The Four Core Genotypes (FCG) is a mouse model system heavily used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the Y Sry- chromosome and thus…
Extensive remodelling of <i>XIST</i> regulatory networks during primate evolution Open
Unravelling how gene regulatory networks are remodelled during evolution is crucial to understand how species adapt to environmental changes. We addressed this question for X-chromosome inactivation, a process essential to female developme…
Species-specific regulation of<i>XIST</i>by the<i>JPX/FTX</i>orthologs Open
X chromosome inactivation (XCI) is an essential process, yet it initiates with remarkable diversity in various mammalian species. XIST, the main trigger of XCI, is controlled in the mouse by an interplay of lncRNA genes (LRGs), some of whi…
Deciphering High-Resolution 3D Chromatin Organization <em>via</em> Capture Hi-C Open
The spatial organization of the genome contributes to its function and regulation in many contexts, including transcription, replication, recombination, and repair. Understanding the exact causality between genome topology and function is …
Inversion of a topological domain leads to restricted changes in its gene expression and affects interdomain communication Open
The interplay between the topological organization of the genome and the regulation of gene expression remains unclear. Depletion of molecular factors (e.g. CTCF) underlying topologically associating domains (TADs) leads to modest alterati…
Molecular biology for green recovery—A call for action Open
Molecular biology holds a vast potential for tackling climate change and biodiversity loss. Yet, it is largely absent from the current strategies. We call for a community-wide action to bring molecular biology to the forefront of climate c…
View article: Multi-omics comparison of malignant and normal uveal melanocytes reveals novel molecular features of uveal melanoma
Multi-omics comparison of malignant and normal uveal melanocytes reveals novel molecular features of uveal melanoma Open
Uveal Melanoma (UM) is a rare cancer resulting from transformation of melanocytes residing in the uveal tract. Integrative analysis has identified four molecular and clinical subsets in UM. To improve our molecular understanding of UM we p…
Inversion of a topological domain leads to restricted changes in its gene expression and affects inter-domain communication Open
The interplay between the topological organization of the genome and the regulation of gene expression remains unclear. Depletion of molecular factors underlying genome topology, such as CTCF and cohesin, leads to modest alterations in gen…
Noncoding RNAs: biology and applications—a Keystone Symposia report Open
The human transcriptome contains many types of noncoding RNAs, which rival the number of protein‐coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi‐interacting RNAs (piRNAs) of only 20 nucleotides…