Edith Sim
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View article: P02 Uncovering the role of NAD(P)H quinone oxidoreductases in <i>Pseudomonas aeruginosa</i> : new avenues for antibiotic potentiators
P02 Uncovering the role of NAD(P)H quinone oxidoreductases in <i>Pseudomonas aeruginosa</i> : new avenues for antibiotic potentiators Open
Background Antimicrobial resistance (AMR) is a critical global health challenge, with Gram-negative pathogens such as Pseudomonas aeruginosa posing a major threat due to their multidrug resistance and clinical prevalence in hospital-acquir…
View article: A Systematic Review (Before 15 October 2024) on the Effects of Ketogenic Diet on Blood Lipid Levels
A Systematic Review (Before 15 October 2024) on the Effects of Ketogenic Diet on Blood Lipid Levels Open
The ketogenic diet (KD) is a high-fat, moderate-protein, and low-carbohydrate dietary regimen; resulting in ketosis–a metabolic state where fats become the primary energy source. This diet was originally used to as a dietary treatment for …
View article: Class I PI3Ks activate stretch-induced autophagy in trabecular meshwork cells
Class I PI3Ks activate stretch-induced autophagy in trabecular meshwork cells Open
Elevated intraocular pressure (IOP) is the primary risk factor for glaucoma, a leading cause of irreversible blindness worldwide. IOP homeostasis is maintained through a balance between aqueous humor production and its drainage through the…
View article: Self‐Assembled BODIPY@Au Core‐Shell Structures for Durable Neuroprotective Phototherapy
Self‐Assembled BODIPY@Au Core‐Shell Structures for Durable Neuroprotective Phototherapy Open
BODIPY analogs are promising photosensitizers for molecular phototherapy; however, they exhibit high dark cytotoxicity and limited singlet oxygen generation capacity. In this study, we developed self‐assembled core‐shell nanophotosensitize…
View article: Intrinsic chemical reactivity of activated human complement component C3: A historical glimpse into research during 1979–1980 on the covalent binding properties of C3, C4 and alpha-2 macroglobulin
Intrinsic chemical reactivity of activated human complement component C3: A historical glimpse into research during 1979–1980 on the covalent binding properties of C3, C4 and alpha-2 macroglobulin Open
A new type of intrinsic activity was revealed in the complement protein C3 during investigations of nucleophilic complement inhibitors. Nascent C3b molecules produced by cleavage-activation of C3 have highly reactive acyl groups which form…
View article: Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway
Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway Open
Background . Tuberculosis remains a major global health concern. The ability to prevent phagosome-lysosome fusion is a key mechanism by which intracellular mycobacteria, including Mycobacterium tuberculosis , achieve long-term persisten…
View article: Drug metabolism and antibiotic resistance in micro‐organisms
Drug metabolism and antibiotic resistance in micro‐organisms Open
Linked Articles This article is part of a themed section on Drug Metabolism and Antibiotic Resistance in Micro‐organisms. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.14/issuetoc
View article: Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti‐tubercular agents using a fragment‐based drug design approach
Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti‐tubercular agents using a fragment‐based drug design approach Open
Background and Purpose With the emergence of extensively drug‐resistant tuberculosis, there is a need for new anti‐tubercular drugs that work through novel mechanisms of action. The meta cleavage product hydrolase, HsaD, has been demonstra…
View article: Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway
Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway Open
Background. Tuberculosis remains a major global health concern. The ability to prevent phagosome-lysosome fusion is a key mechanism by which intracellular mycobacteria, includingMycobacterium tuberculosis, achieve long-term persistence wit…