Edmund M. Qiao
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View article: Baseline atrial volume indices and major adverse cardiac events following thoracic radiotherapy
Baseline atrial volume indices and major adverse cardiac events following thoracic radiotherapy Open
Introduction Patients receiving thoracic radiotherapy (RT) have an increased risk of major adverse cardiac events (MACE) posttreatment. We utilized machine learning (ML) to discover novel predictors of MACE and validated them on an externa…
View article: Supplementary Materials and Methods from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment
Supplementary Materials and Methods from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment Open
Supplementary Materials and Methods with expanded description of cell lines, 2D co-culture of ESCC cells and CAFs, 3D tumoroid and organotypic cultures, xenograft tumors, generation of CRISPR knockout cell lines, real-time qPCR, histology …
View article: Table S2 from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment
Table S2 from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment Open
Results of the cytokine array of conditioned media from co-cultured ESCC cells and CAFs, presented as relative fluorescence
View article: Data from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment
Data from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment Open
The tumor microenvironment (TME) plays a major role in the pathogenesis of multiple cancer types, including upper-gastrointestinal (GI) cancers that currently lack effective therapeutic options. Cancer-associated fibroblasts (CAF) are an e…
View article: Data from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment
Data from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment Open
The tumor microenvironment (TME) plays a major role in the pathogenesis of multiple cancer types, including upper-gastrointestinal (GI) cancers that currently lack effective therapeutic options. Cancer-associated fibroblasts (CAF) are an e…
View article: Table S2 from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment
Table S2 from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment Open
Results of the cytokine array of conditioned media from co-cultured ESCC cells and CAFs, presented as relative fluorescence
View article: Table S1 from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment
Table S1 from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment Open
sequences for qPCR probes used in the manuscript
View article: Table S1 from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment
Table S1 from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment Open
sequences for qPCR probes used in the manuscript
View article: Figures S1-12, Tables S3-6 from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment
Figures S1-12, Tables S3-6 from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment Open
Fig. S1 demonstrates that human CAFs survive within xenograft tumors Fig. S2 shows the results of quality control for CRISPR-mediated knockout cell lines Fig. S3 shows enhanced tumor growth is ESCC cells are co-implanted with CAF Fig. S4 s…
View article: Supplementary Materials and Methods from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment
Supplementary Materials and Methods from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment Open
Supplementary Materials and Methods with expanded description of cell lines, 2D co-culture of ESCC cells and CAFs, 3D tumoroid and organotypic cultures, xenograft tumors, generation of CRISPR knockout cell lines, real-time qPCR, histology …
View article: Figures S1-12, Tables S3-6 from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment
Figures S1-12, Tables S3-6 from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment Open
Fig. S1 demonstrates that human CAFs survive within xenograft tumors Fig. S2 shows the results of quality control for CRISPR-mediated knockout cell lines Fig. S3 shows enhanced tumor growth is ESCC cells are co-implanted with CAF Fig. S4 s…
View article: Association Between Primary Care Use Prior to Cancer Diagnosis and Subsequent Cancer Mortality in the Veterans Affairs Health System
Association Between Primary Care Use Prior to Cancer Diagnosis and Subsequent Cancer Mortality in the Veterans Affairs Health System Open
Importance Primary care physicians (PCPs) are significant contributors of early cancer detection, yet few studies have investigated whether consistent primary care translates to improved downstream outcomes. Objective To evaluate the assoc…
View article: Association Between Prostate-Specific Antigen Screening and Prostate Cancer Mortality Among Non-Hispanic Black and Non-Hispanic White US Veterans
Association Between Prostate-Specific Antigen Screening and Prostate Cancer Mortality Among Non-Hispanic Black and Non-Hispanic White US Veterans Open
Importance Black men have higher prostate cancer incidence and mortality than non-Hispanic White men. However, Black men have been underrepresented in clinical trials of prostate-specific antigen (PSA) screening; thus, there is a lack of d…
View article: Evaluating High-Dimensional Machine Learning Models to Predict Hospital Mortality Among Older Patients With Cancer
Evaluating High-Dimensional Machine Learning Models to Predict Hospital Mortality Among Older Patients With Cancer Open
PURPOSE Older hospitalized cancer patients face high risks of hospital mortality. Improved risk stratification could help identify high-risk patients who may benefit from future interventions, although we lack validated tools to predict in…
View article: Association of Health-Care System and Survival in African American and Non-Hispanic White Patients With Bladder Cancer
Association of Health-Care System and Survival in African American and Non-Hispanic White Patients With Bladder Cancer Open
Background African American patients with bladder cancer have inferior outcomes compared with non-Hispanic White (White) patients. We hypothesize that access to health care is a primary determinant of this disparity. We compared outcomes b…
View article: Evaluating Prostate-Specific Antigen Screening for Young African American Men With Cancer
Evaluating Prostate-Specific Antigen Screening for Young African American Men With Cancer Open
Background Despite higher risks associated with prostate cancer, young African American men are poorly represented in prostate-specific antigen (PSA) trials, which limits proper evidence-based guidance. We evaluated the impact of PSA scree…
View article: Impact of underlying malignancy on emergency department utilization and outcomes
Impact of underlying malignancy on emergency department utilization and outcomes Open
Purpose Cancer patients frequently utilize the emergency department (ED) for a variety of diagnoses both related to and unrelated to their cancer, yet ED outcomes for cancer patients are not well documented. This study sought to define ris…
View article: Pancreatic Cancer–Related Mutational Burden Is Not Increased in a Patient Cohort With Clinically Severe Chronic Pancreatitis
Pancreatic Cancer–Related Mutational Burden Is Not Increased in a Patient Cohort With Clinically Severe Chronic Pancreatitis Open
INTRODUCTION: Chronic pancreatitis is associated with an increased risk of developing pancreatic cancer, and patients with inherited forms of pancreatitis are at greatest risk. We investigated whether clinical severity of pancreatitis coul…
View article: Treatment Discontinuation in Patients With Muscle-Invasive Bladder Cancer Undergoing Chemoradiation
Treatment Discontinuation in Patients With Muscle-Invasive Bladder Cancer Undergoing Chemoradiation Open
With a low rate of treatment discontinuation, CRT is an effective and feasible treatment option for the typically elderly and comorbid population of patients with MIBC. In addition to identified predictors of treatment discontinuation (poo…
View article: Hypofractionated radiation therapy as palliative management for symptomatic and local control of advanced thoracic malignancies
Hypofractionated radiation therapy as palliative management for symptomatic and local control of advanced thoracic malignancies Open
Palliative SBRT has the advantage of higher biologic dose without protracted course for patients with limited prognosis. Patients showed significant symptom palliation and long-term local control. Palliative SBRT represents a reasonable tr…
View article: Evaluating the clinical trends and benefits of low‐dose computed tomography in lung cancer patients
Evaluating the clinical trends and benefits of low‐dose computed tomography in lung cancer patients Open
Background Despite guideline recommendations, utilization of low‐dose computed tomography (LDCT) for lung cancer screening remains low. The driving factors behind these low rates and the real‐world effect of LDCT utilization on lung cancer…
View article: Association of race and health care system with disease stage and survival in veterans with larynx cancer
Association of race and health care system with disease stage and survival in veterans with larynx cancer Open
Background Black patients with laryngeal squamous cell carcinoma (LSCC) historically have inferior outcomes in comparison with White patients. The authors investigated these racial disparities within the Veterans Health Administration (VHA…
View article: Clinical Data Prediction Model to Identify Patients With Early-Stage Pancreatic Cancer
Clinical Data Prediction Model to Identify Patients With Early-Stage Pancreatic Cancer Open
PURPOSE Pancreatic cancer is an aggressive malignancy with patients often experiencing nonspecific symptoms before diagnosis. This study evaluates a machine learning approach to help identify patients with early-stage pancreatic cancer fro…
View article: Prognostic Utility of Pretreatment Neutrophil-Lymphocyte Ratio in Advanced Larynx Cancer
Prognostic Utility of Pretreatment Neutrophil-Lymphocyte Ratio in Advanced Larynx Cancer Open
Purpose: Neutrophil-lymphocyte ratio has been explored as a prognosticator in several cancer types, but its association with larynx cancer outcomes is not well known. We aimed to identify an optimal NLR cutoff point and examine the prognos…