Edoardo Missiaglia
YOU?
Author Swipe
View article: Divergent molecular pathways drive monomorphic epitheliotropic and enteropathy-associated intestinal T-cell lymphoma
Divergent molecular pathways drive monomorphic epitheliotropic and enteropathy-associated intestinal T-cell lymphoma Open
Enteropathy-associated intestinal T-cell lymphoma (EATL) and monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) have distinctive clinical context, morphology, and immunophenotype. To characterize their genetic and molecular spe…
View article: 162 | PLURI‐OMICS CHARACTERIZATION ESTABLISHES MONOMORPHIC EPITHELIOTROPIC INTESTINAL T‐CELL LYMPHOMA AND ENTEROPATHY ASSOCIATED T‐CELL LYMPHOMA AS TWO DISTINCT ENTITIES
162 | PLURI‐OMICS CHARACTERIZATION ESTABLISHES MONOMORPHIC EPITHELIOTROPIC INTESTINAL T‐CELL LYMPHOMA AND ENTEROPATHY ASSOCIATED T‐CELL LYMPHOMA AS TWO DISTINCT ENTITIES Open
View article: Case Report: Lasting complete response to pembrolizumab in mismatch repair-deficient cardiac sarcoma: a genomic characterization
Case Report: Lasting complete response to pembrolizumab in mismatch repair-deficient cardiac sarcoma: a genomic characterization Open
Sarcomas are traditionally considered “cold” tumors with poor response to immunotherapy. However, evidence accumulating over the last years shows that immune checkpoint inhibitors (ICIs) may have a role in selected sarcoma patients accordi…
View article: Binding of RHOA G17V to p300 enhances its HAT activity: a new mechanism of epigenetic deregulation in TFH lymphoma
Binding of RHOA G17V to p300 enhances its HAT activity: a new mechanism of epigenetic deregulation in TFH lymphoma Open
The RHOA G17V mutation is highly recurrent in T follicular helper (TFH) cell lymphoma of the angioimmunoblastic type (AITL; 60%-70% of cases) and frequently associated with mutations in other T-cell receptor signaling genes, including CD28…
View article: Reporting of somatic variants in clinical cancer care: recommendations of the Swiss Society of Molecular Pathology
Reporting of somatic variants in clinical cancer care: recommendations of the Swiss Society of Molecular Pathology Open
View article: Lack of SMARCB1 expression characterizes a subset of human and murine peripheral T-cell lymphomas
Lack of SMARCB1 expression characterizes a subset of human and murine peripheral T-cell lymphomas Open
Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous group of malignancies with poor outcome. Here, we identify a subgroup, PTCL-NOS SMARCB1- , which is characterized by the lack of the SMARCB1 protein and occu…
View article: Deep phenotyping of nodal T-cell lymphomas reveals immune alterations and therapeutic targets
Deep phenotyping of nodal T-cell lymphomas reveals immune alterations and therapeutic targets Open
Whereas immunotherapies have revolutionized the treatment of different solid and hematological cancers, their efficacy in nodal peripheral T-cell lymphomas (PTCLs) is limited, due to a lack of understanding of the immune response they trig…
View article: A phase 1 trial of adoptive transfer of vaccine-primed autologous circulating T cells in ovarian cancer
A phase 1 trial of adoptive transfer of vaccine-primed autologous circulating T cells in ovarian cancer Open
View article: TCL-473 Role of Microsatellite Instability in the Oncogenesis of Primary Intestinal T-Cell Lymphomas
TCL-473 Role of Microsatellite Instability in the Oncogenesis of Primary Intestinal T-Cell Lymphomas Open
View article: POSTER: TCL-330 RHOA G17V Potentiates CD28-Induced NFAT Transcriptional Activity by Modulating p300 Activity: A Step Further in the Understanding of Follicular Helper T-Cell Lymphoma
POSTER: TCL-330 RHOA G17V Potentiates CD28-Induced NFAT Transcriptional Activity by Modulating p300 Activity: A Step Further in the Understanding of Follicular Helper T-Cell Lymphoma Open
View article: LACK OF SMARCB1 EXPRESSION CHARACTERIZES A SUBSET OF PERIPHERAL T‐CELL LYMPHOMAS ENRICHED IN CHILDREN AND YOUNG ADULTS
LACK OF SMARCB1 EXPRESSION CHARACTERIZES A SUBSET OF PERIPHERAL T‐CELL LYMPHOMAS ENRICHED IN CHILDREN AND YOUNG ADULTS Open
Introduction: Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous group of malignancies with poor outcome. Because patients respond poorly to current treatment regimens, identification of new therapeutic strat…
View article: supplementary Table S1 and S2 from <i>BRAF</i> <i>V600E</i> Mutant Colorectal Cancer Subtypes Based on Gene Expression
supplementary Table S1 and S2 from <i>BRAF</i> <i>V600E</i> Mutant Colorectal Cancer Subtypes Based on Gene Expression Open
Table S1: Definitions of mutation calls used in this study;Table S2: List of genes with non-zero coefficients obtained by the classifier used to categorize gene expression profiles into BM1 and BM2.
View article: Data from Clinical Application of Prognostic Gene Expression Signature in Fusion Gene–Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group
Data from Clinical Application of Prognostic Gene Expression Signature in Fusion Gene–Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group Open
Purpose: Pediatric rhabdomyosarcoma (RMS) has two common histologic subtypes: embryonal (ERMS) and alveolar (ARMS). PAX–FOXO1 fusion gene status is a more reliable prognostic marker than alveolar histology, whereas fusion gen…
View article: supplementary methods and legends from <i>BRAF</i> <i>V600E</i> Mutant Colorectal Cancer Subtypes Based on Gene Expression
supplementary methods and legends from <i>BRAF</i> <i>V600E</i> Mutant Colorectal Cancer Subtypes Based on Gene Expression Open
This file contains the supplementary methods that either describe the methodological part related to supplementary figures or the detailed aspects for the following methods: clustering, pathway analysis, survival, methylation and proteomic…
View article: Supplementary Tables 1-3 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy
Supplementary Tables 1-3 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy Open
PDF file - 62K
View article: Supplementary Table 4 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy
Supplementary Table 4 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy Open
PDF file - 256K
View article: Supplementary Figure 6 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy
Supplementary Figure 6 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy Open
PDF file - 1.1MB
View article: Data from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy
Data from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy Open
Purpose: Rhabdomyosarcomas are a major cause of cancer death in children, described with MYCN amplification and, in the alveolar subtype, transcription driven by the PAX3-FOXO1 fusion protein. Our aim was to determine the pre…
View article: Supplementary Figure 1 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy
Supplementary Figure 1 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy Open
PDF file - 287K
View article: supplementary Table S3 from <i>BRAF</i> <i>V600E</i> Mutant Colorectal Cancer Subtypes Based on Gene Expression
supplementary Table S3 from <i>BRAF</i> <i>V600E</i> Mutant Colorectal Cancer Subtypes Based on Gene Expression Open
Association of BM subtyping with known clinical features.
View article: Suplpementary Figure 1 from Clinical Application of Prognostic Gene Expression Signature in Fusion Gene–Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group
Suplpementary Figure 1 from Clinical Application of Prognostic Gene Expression Signature in Fusion Gene–Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group Open
Plot of the mean expression versus the standard deviation (SD) of all the genes included in (A) ITCC/CIT dataset (Affy HGU133plus2 platform) or (B) COG/IRSG dataset (Affy HGU133a platform). Genes included in the nCounter assay were colored…
View article: Supplementary Figure 3 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy
Supplementary Figure 3 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy Open
PDF file - 242K
View article: Supplementary Figure 5 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy
Supplementary Figure 5 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy Open
PDF file - 750K
View article: supplementary Figures from <i>BRAF</i> <i>V600E</i> Mutant Colorectal Cancer Subtypes Based on Gene Expression
supplementary Figures from <i>BRAF</i> <i>V600E</i> Mutant Colorectal Cancer Subtypes Based on Gene Expression Open
Figure S1. Principal component analysis and hierarchical clustering of the 218 BRAF mutant patient cohort;Figure S2: Gene-wise and patient-wise biclustering heatmap of the 218 BRAF mutant patient cohort and comparison of BRAF mutant subtyp…
View article: supplementary methods and legends from <i>BRAF</i> <i>V600E</i> Mutant Colorectal Cancer Subtypes Based on Gene Expression
supplementary methods and legends from <i>BRAF</i> <i>V600E</i> Mutant Colorectal Cancer Subtypes Based on Gene Expression Open
This file contains the supplementary methods that either describe the methodological part related to supplementary figures or the detailed aspects for the following methods: clustering, pathway analysis, survival, methylation and proteomic…
View article: CCR Translation for This Article from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy
CCR Translation for This Article from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy Open
CCR Translation for This Article from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy
View article: Suplpementary Figure 1 from Clinical Application of Prognostic Gene Expression Signature in Fusion Gene–Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group
Suplpementary Figure 1 from Clinical Application of Prognostic Gene Expression Signature in Fusion Gene–Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group Open
Plot of the mean expression versus the standard deviation (SD) of all the genes included in (A) ITCC/CIT dataset (Affy HGU133plus2 platform) or (B) COG/IRSG dataset (Affy HGU133a platform). Genes included in the nCounter assay were colored…
View article: Supplementary Figure 5 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy
Supplementary Figure 5 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy Open
PDF file - 750K
View article: Supplementary Data from A Composite Gene Expression Signature Optimizes Prediction of Colorectal Cancer Metastasis and Outcome
Supplementary Data from A Composite Gene Expression Signature Optimizes Prediction of Colorectal Cancer Metastasis and Outcome Open
Supplementary Figures and Tables
View article: Data from Clinical Application of Prognostic Gene Expression Signature in Fusion Gene–Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group
Data from Clinical Application of Prognostic Gene Expression Signature in Fusion Gene–Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group Open
Purpose: Pediatric rhabdomyosarcoma (RMS) has two common histologic subtypes: embryonal (ERMS) and alveolar (ARMS). PAX–FOXO1 fusion gene status is a more reliable prognostic marker than alveolar histology, whereas fusion gen…