Eduarda Behenck Medeiros
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View article: Neuromodulation with low-intensity pulsed ultrasound (Lipus) combined with curcumin-gold nanoparticles (Cur-AuNPs) in an Alzheimer's disease model
Neuromodulation with low-intensity pulsed ultrasound (Lipus) combined with curcumin-gold nanoparticles (Cur-AuNPs) in an Alzheimer's disease model Open
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder that requires innovative therapeutic strategies. This is the first study to evaluate the synergistic effects of LIPUS and CUR-AuNPs in an AD model, which…
View article: Effect of administration of vitamin D3 alone or combined with donepezil on the memory of adult and aged ovariectomized rat
Effect of administration of vitamin D3 alone or combined with donepezil on the memory of adult and aged ovariectomized rat Open
Background The increasing prevalence of neurodegenerative diseases, particularly among women post‐menopause, is linked to the decline in 17 β estradiol (E2). Vitamin D deficiency, common in older individuals, exacerbates this risk due to i…
View article: Vitamin D and donepezil intervention in ovariectomized rats: modulating neuroinflammation in the aging brain
Vitamin D and donepezil intervention in ovariectomized rats: modulating neuroinflammation in the aging brain Open
Background Aging is a natural, irreversible process that can be successful or pathological, resulting in chronic degenerative diseases such as Alzheimer’s disease. Low levels of estrogen characterize menopause. Research reveals that the la…
View article: Cognitive performance in individuals aged 80 or over from south of Brazil
Cognitive performance in individuals aged 80 or over from south of Brazil Open
Background The population aged 80 or over has increased, which may predispose people to dementia. Validated scales are used to diagnose them. The study aimed to compare cognitive evolution and associated factors in individuals aged 80 or o…
View article: Lithium modulates energy metabolism in the frontal cortex of rats treated with ketamine
Lithium modulates energy metabolism in the frontal cortex of rats treated with ketamine Open
Bipolar Disorder (BD) is a chronic and highly debilitating psychiatric illness formerly called manic depression. Mood-stabilizing agents such as lithium (Li) are the primary drugs used to treat BD. Assessing the effect of these mood stabil…
View article: Interference of different anesthetic agents on behavior and oxidative stress in the animal model of Aβ<sub>1‐42</sub>‐induced dementia in mice.
Interference of different anesthetic agents on behavior and oxidative stress in the animal model of Aβ<sub>1‐42</sub>‐induced dementia in mice. Open
Background Alzheimer’s disease (AD) is a progressive neurodegenerative disease. The animal model of AD‐like dementia induced by the peptide β‐amyloid 1‐42 (Aβ 1‐42 ) is widely used. However, the animals have to be anesthetized and no studi…
View article: Vitamin D3 Improves Spatial Memory and Modulates Cytokine Levels in Aged Rats
Vitamin D3 Improves Spatial Memory and Modulates Cytokine Levels in Aged Rats Open
Background: Vitamin D deficiency is associated with an increased risk of dementia. An association between vitamin D deficiency and subjective cognitive complaints in geriatric patients has been reported. Objective: This study aimed to eval…
View article: Neuroprotective Effects of a Combined Therapy With Memantine, Donepezil and Vitamin D in Ovariectomized Female Mice Subjected to Dementia Model
Neuroprotective Effects of a Combined Therapy With Memantine, Donepezil and Vitamin D in Ovariectomized Female Mice Subjected to Dementia Model Open
The postmenopausal period is characterized by a decrease in the hormonal supply which is associated with Alzheimer's Disease (AD). Vitamin D is neuroprotective and can be used in combination with pre-existing medications to improve its eff…
View article: P2‐090: THE EFFECT OF MEMANTINE AND/OR FLUOXETINE ON THE BEHAVIORAL ALTERATIONS AND BDNF LEVELS OF RATS SUBJECTED TO CHRONIC MILD STRESS AND TO AMYLOID BETA‐PEPTIDE (1‐42)‐INDUCED NEUROTOXICITY
P2‐090: THE EFFECT OF MEMANTINE AND/OR FLUOXETINE ON THE BEHAVIORAL ALTERATIONS AND BDNF LEVELS OF RATS SUBJECTED TO CHRONIC MILD STRESS AND TO AMYLOID BETA‐PEPTIDE (1‐42)‐INDUCED NEUROTOXICITY Open
Alzheimer's disease (AD) is the main cause of dementia in the elderly and may be associated with comorbidities such as depression. Therefore, this study aimed to evaluate the effect of memantine and/or fluoxetine on the behavioral alterati…
View article: Contilisant, a Tetratarget Small Molecule for Alzheimer’s Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile
Contilisant, a Tetratarget Small Molecule for Alzheimer’s Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile Open
Contilisant, a permeable, antioxidant, and neuroprotectant agent, showing high nM affinity at H3R and excellent inhibition of the monoamine oxidases and cholinesterases, is an affine and selective S1R agonist in the nanomolar range, based …
View article: [P3–126]: INVOLVEMENT OF NEUROINFLAMMATION IN THE MEMORY OF ADULT AND OLD OFFSPRING FROM WISTAR RATS WITH FOLIC ACID DEFICIENCY OR SUPPLEMENTATION DURING PREGNANCY
[P3–126]: INVOLVEMENT OF NEUROINFLAMMATION IN THE MEMORY OF ADULT AND OLD OFFSPRING FROM WISTAR RATS WITH FOLIC ACID DEFICIENCY OR SUPPLEMENTATION DURING PREGNANCY Open
The deficiency or supplementation of folic acid (FA) during the pregnancy can interfere in aging process. Therefore, the aim of the present study was to assess the impact of maternal deficiency and supplementation of AF on memory and neuro…