Eduardo Beltrán
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View article: Suplemento Especial - Resúmenes de Investigación: XXXVI Congreso de Sociedad Latinoamericana de Oncología Pediátrica (SLAOP) y XXIII Congreso de la Asociación Colombiana de Hematología y Oncología Pediátrica – Cali, junio del 2025
Suplemento Especial - Resúmenes de Investigación: XXXVI Congreso de Sociedad Latinoamericana de Oncología Pediátrica (SLAOP) y XXIII Congreso de la Asociación Colombiana de Hematología y Oncología Pediátrica – Cali, junio del 2025 Open
View article: Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice
Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice Open
View article: Dissection of single-cell landscapes for the development of chimeric antigen receptor T cells in Hodgkin lymphoma
Dissection of single-cell landscapes for the development of chimeric antigen receptor T cells in Hodgkin lymphoma Open
The success of targeted therapies for hematological malignancies has heralded their potential as both salvage treatment and early treatment lines, reducing the need for high-dose, intensive, and often toxic chemotherapeutic regimens. For y…
View article: High-resolution profile of neoantigen-specific TCR activation links moderate stimulation to increased resilience of engineered TCR-T cells
High-resolution profile of neoantigen-specific TCR activation links moderate stimulation to increased resilience of engineered TCR-T cells Open
View article: Twin study identifies early immunological and metabolic dysregulation of CD8 <sup>+</sup> T cells in multiple sclerosis
Twin study identifies early immunological and metabolic dysregulation of CD8 <sup>+</sup> T cells in multiple sclerosis Open
Multiple sclerosis (MS) is an inflammatory neurological disease of the central nervous system with a subclinical phase preceding frank neuroinflammation. CD8 + T cells are abundant within MS lesions, but their potential role in disease pat…
View article: Innate immune memory after brain injury drives inflammatory cardiac dysfunction
Innate immune memory after brain injury drives inflammatory cardiac dysfunction Open
The medical burden of stroke extends beyond the brain injury itself and is largely determined by chronic comorbidities that develop secondarily. We hypothesized that these comorbidities might share a common immunological cause, yet chronic…
View article: Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy
Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy Open
View article: Innate immune memory after brain injury drives inflammatory cardiac dysfunction
Innate immune memory after brain injury drives inflammatory cardiac dysfunction Open
The enormous medical burden of stroke is not only due to the brain injury itself and the acute systemic effects, but is largely determined by chronic comorbidities that develop secondarily after stroke. We hypothesized that the high rate o…
View article: A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model
A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model Open
Multiple sclerosis (MS) involves the infiltration of autoreactive T cells into the CNS, yet we lack a comprehensive understanding of the signaling pathways that regulate this process. Here, we conducted a genome-wide in vivo CRISPR screen …
View article: T:B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity
T:B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity Open
Meningeal ectopic lymphoid follicle-like structures (eLFs) have been described in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), but their role in CNS autoimmunity is unclear. To analyze the c…
View article: Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia
Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia Open
View article: Antibodies Against Glutamic Acid Decarboxylase 65 Are Locally Produced in the CSF and Arise During Affinity Maturation
Antibodies Against Glutamic Acid Decarboxylase 65 Are Locally Produced in the CSF and Arise During Affinity Maturation Open
GAD65-specific B cells are present in the CNS and represent a sizable fraction of CSF B cells early in the disease course. The anti-GAD65 response in the CSF is polyclonal and shows evidence of antigen-driven affinity maturation required f…
View article: Persistent virus-specific and clonally expanded antibody-secreting cells respond to induced self-antigen in the CNS
Persistent virus-specific and clonally expanded antibody-secreting cells respond to induced self-antigen in the CNS Open
B cells contribute to the pathogenesis of both cellular- and humoral-mediated central nervous system (CNS) inflammatory diseases through a variety of mechanisms. In such conditions, B cells may enter the CNS parenchyma and contribute to lo…
View article: Correction: Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis
Correction: Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis Open
During data analysis for a follow-up project, the authors found that the number of patients who received ocrelizumab infusions in the metadata underlying Fig. S3 E was incorrect.The corrected Fig. S3 with the revised panel E is provided he…
View article: 2022-RA-928-ESGO Reprogramming of patient-derived HGSOC organoids following carboplatin treatment links stemness potential and mechanisms of resistance
2022-RA-928-ESGO Reprogramming of patient-derived HGSOC organoids following carboplatin treatment links stemness potential and mechanisms of resistance Open
Introduction/Background Targeted therapeutics, including bevacizumab and PARPi, gained traction for the maintenance treatment of high-grade serous ovarian cancer (HGSOC) following platinum-based chemotherapy. However, there are still limit…
View article: High-resolution profiling of neoantigen-specific T cell receptor activation signatures links moderate stimulation patterns to resilience and sustained tumor control
High-resolution profiling of neoantigen-specific T cell receptor activation signatures links moderate stimulation patterns to resilience and sustained tumor control Open
Neoantigen-specific T cell receptors (neoTCRs) promise a safe, highly personalized therapeutic approach in anti-tumor immunotherapy. Substantial progress has been made regarding their identification whereas detailed functional assessment o…
View article: Antigen-specific immune reactions by expanded CD8+ T cell clones from HLA-B*27-positive patients with spondyloarthritis
Antigen-specific immune reactions by expanded CD8+ T cell clones from HLA-B*27-positive patients with spondyloarthritis Open
Spondyloarthritis (SpA) is a chronic inflammatory disease that is tightly linked to HLA-B*27 but the pathophysiological basis of this link is still unknown. It is discussed whether either the instability of HLA-B*27 molecules triggers pred…
View article: Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis
Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis Open
Epstein–Barr virus (EBV) infection precedes multiple sclerosis (MS) pathology and cross-reactive antibodies might link EBV infection to CNS autoimmunity. As an altered anti-EBV T cell reaction was suggested in MS, we queried peripheral blo…
View article: Persistent virus-specific and clonally expanded antibody secreting cells respond to induced self antigen in the CNS
Persistent virus-specific and clonally expanded antibody secreting cells respond to induced self antigen in the CNS Open
B cells contribute to the pathogenesis of both cellular- and humoral-mediated central nervous system (CNS) inflammatory diseases through a variety of mechanisms. In such conditions, B cells may enter the CNS parenchyma and contribute to lo…
View article: Identification of essential modules regulating T cell migration to the central nervous system in multiple sclerosis
Identification of essential modules regulating T cell migration to the central nervous system in multiple sclerosis Open
SUMMARY Multiple sclerosis (MS) is a neuroinflammatory disease initiated by the infiltration of autoreactive T cells into the central nervous system (CNS). Several molecules that modulate T cell CNS infiltration in MS have been identified,…
View article: Single-cell multiomics in neuroinflammation
Single-cell multiomics in neuroinflammation Open
The central nervous system (CNS) is, more than other organs, particularly vulnerable to inflammation and immune responses must be tightly controlled in order to maintain host protection. Accordingly, neuroinflammation is an orchestrated pr…
View article: Twin study reveals non-heritable immune perturbations in multiple sclerosis
Twin study reveals non-heritable immune perturbations in multiple sclerosis Open
View article: Intranasal Dexamethasone: a New Clinical Trial For The Control of Inflammation and Neuroinflammation in Covid-19 Patients
Intranasal Dexamethasone: a New Clinical Trial For The Control of Inflammation and Neuroinflammation in Covid-19 Patients Open
COVID-19 has produced more than 176 million infected individuals and almost 3.2 million deaths worldwide. The infection results in a dysregulated systemic inflammation, multi-organ dysfunction, and critical illness. Cells of the central ne…
View article: Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity
Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity Open
View article: Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABA <sub>A</sub> receptor encephalitis
Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABA <sub>A</sub> receptor encephalitis Open
Significance Antibodies recognizing the neuronal gamma-aminobutyric acid A receptor (GABA A -R) cause severe encephalitis by triggering internalization of the antibody–receptor complexes in inhibitory synapses, which leads to hyperexcitabi…
View article: Correction to: Archeological neuroimmunology: resurrection of a pathogenic immune response from a historical case sheds light on human autoimmune encephalomyelitis and multiple sclerosis
Correction to: Archeological neuroimmunology: resurrection of a pathogenic immune response from a historical case sheds light on human autoimmune encephalomyelitis and multiple sclerosis Open
View article: Oligodendrocyte myelin glycoprotein as a novel target for pathogenic autoimmunity in the CNS
Oligodendrocyte myelin glycoprotein as a novel target for pathogenic autoimmunity in the CNS Open
View article: Archeological neuroimmunology: resurrection of a pathogenic immune response from a historical case sheds light on human autoimmune encephalomyelitis and multiple sclerosis
Archeological neuroimmunology: resurrection of a pathogenic immune response from a historical case sheds light on human autoimmune encephalomyelitis and multiple sclerosis Open
Aim of our study was to identify the target auto-antigen in the central nervous system recognized by the immune system of a unique patient, who died more than 60 years ago from a disease with pathological changes closely resembling multipl…
View article: Tissue-resident CD8+ memory T cells in multiple sclerosis
Tissue-resident CD8+ memory T cells in multiple sclerosis Open
View article: An expanded parenchymal CD8+ T cell clone in GABA<sub>A</sub> receptor encephalitis
An expanded parenchymal CD8+ T cell clone in GABA<sub>A</sub> receptor encephalitis Open
The role of T cells in autoimmune encephalitis syndromes with autoantibodies against cell surface antigens is still enigmatic. Here we analyzed the T cell receptor repertoires of CD8+ and CD4+ T cells in a patient with “idiopathic” gamma‐a…