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View article: Emotional and instrumental social support and older adults’ depressive symptoms: collaborative individual participant data meta-analysis of 11 population-based studies of aging
Emotional and instrumental social support and older adults’ depressive symptoms: collaborative individual participant data meta-analysis of 11 population-based studies of aging Open
Social support is considered a protective factor against depression, but there are inconsistent findings regarding social support and depression in older adults. We aimed to clarify the association between emotional and instrumental social…
View article: Depressive symptoms among Brazilian elderly people: a study based on the National Health Survey - 2019
Depressive symptoms among Brazilian elderly people: a study based on the National Health Survey - 2019 Open
The aim is to investigate the prevalence and identify sociodemographic factors and health conditions associated with depressive symptoms among Brazilian elderly people. Data collected from 21,965 elderly people participating in the Nationa…
View article: Sintomas depressivos na população idosa brasileira: um estudo baseado na Pesquisa Nacional de Saúde - 2019
Sintomas depressivos na população idosa brasileira: um estudo baseado na Pesquisa Nacional de Saúde - 2019 Open
Resumo O objetivo é investigar a prevalência e identificar os fatores sociodemográficos e as condições de saúde associados a sintomas depressivos na população idosa brasileira. Foram utilizados dados coletados junto a 21.965 participantes …
View article: Role of Myofibroblasts in the Repair of Iatrogenic Preterm Membranes Subjected to Mechanical Stimulation
Role of Myofibroblasts in the Repair of Iatrogenic Preterm Membranes Subjected to Mechanical Stimulation Open
Objective We examined the role of myofibroblasts in regulating Cx43 and collagen structure in iatrogenic preterm amniotic membrane (AM) defects subjected to mechanical stimulation. Method Preterm AM specimens were collected from women unde…
View article: Additive Impact of Cardiometabolic Multimorbidity and Depression on Cognitive Decline: Findings from Multi‐Regional Cohorts and Generalization from Community to Clinic
Additive Impact of Cardiometabolic Multimorbidity and Depression on Cognitive Decline: Findings from Multi‐Regional Cohorts and Generalization from Community to Clinic Open
Background To estimate the additive associations of cardiometabolic multimorbidity (CMM) and depression on long‐term cognitive trajectory in multi‐regional cohorts and validate the generalizability of the findings in varying clinical setti…
View article: Independent and joint associations of cardiometabolic multimorbidity and depression on cognitive function: findings from multi-regional cohorts and generalisation from community to clinic
Independent and joint associations of cardiometabolic multimorbidity and depression on cognitive function: findings from multi-regional cohorts and generalisation from community to clinic Open
View article: Lifestyle and incident dementia: A COSMIC individual participant data meta‐analysis
Lifestyle and incident dementia: A COSMIC individual participant data meta‐analysis Open
INTRODUCTION The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dem…
View article: Association between depressive symptoms and social support in a nationally representative sample of older adults (ELSI-Brasil)
Association between depressive symptoms and social support in a nationally representative sample of older adults (ELSI-Brasil) Open
The present findings highlight the importance of social relations in determining the presence of depressive symptoms and reinforce the need to implement public policies aimed at strengthening social networks to minimize this public health …
View article: Additive Impact of Cardiometabolic Multimorbidity and Depression on Cognitive Decline: Findings from Multi-Regional Cohorts and Generalization from Community to Clinic
Additive Impact of Cardiometabolic Multimorbidity and Depression on Cognitive Decline: Findings from Multi-Regional Cohorts and Generalization from Community to Clinic Open
View article: Types of social support and depressive symptoms in older adults: An IPD meta‐analysis of longitudinal ageing studies
Types of social support and depressive symptoms in older adults: An IPD meta‐analysis of longitudinal ageing studies Open
Background Depression is a known risk factor for dementia, and social support may lower the risk of depression in older adults. There is, however, a lack of longitudinal analyses examining the association between emotional versus instrumen…
View article: Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing
Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing Open
Background: Good social connections are proposed to positively influence the course of cognitive decline by stimulating cognitive reserve and buffering harmful stress-related health effects. Prior meta-analytic research has uncovered links…
View article: Prevalence of dynapenia and overlap with disability, depression, and executive dysfunction
Prevalence of dynapenia and overlap with disability, depression, and executive dysfunction Open
OBJECTIVE: This study aims to investigate handgrip strength and dynapenia prevalence among older adults stratified by Brazilian macroregions. Additionally, we aim to evaluate the overlap between dynapenia and Instrumental Activities of Dai…
View article: Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing
Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing Open
Introduction Previous meta‐analyses have linked social connections and mild cognitive impairment, dementia, and mortality. However, these used aggregate data from North America and Europe and examined a limited number of social connection …
View article: Association among race/color, gender, and intrinsic capacity: results from the ELSI-Brazil study
Association among race/color, gender, and intrinsic capacity: results from the ELSI-Brazil study Open
OBJECTIVE: To investigate associations among race/color, gender, and intrinsic capacity (IC) (total and by domains) in middle-aged and older adults from a Brazilian cohort. As a secondary objective, we investigate these associations across…
View article: Sex differences in dementia risk and risk factors: Individual‐participant data analysis using 21 cohorts across six continents from the COSMIC consortium
Sex differences in dementia risk and risk factors: Individual‐participant data analysis using 21 cohorts across six continents from the COSMIC consortium Open
Introduction Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno‐regional groups. Methods A total of 29,850 participants (58% women) from 21 cohorts across six continents…
View article: Depressive symptoms and self-rated health among Brazilian older adults: baseline data from the ELSI-Brazil study
Depressive symptoms and self-rated health among Brazilian older adults: baseline data from the ELSI-Brazil study Open
Having depressive symptoms may contribute towards having a poorer perception of health, even in the absence of health conditions. SRH is a multidimensional construct that can accurately reflect a person's state of general mental health.
View article: Association among race/color, gender, and intrinsic capacity: results from the ELSI-Brazil study
Association among race/color, gender, and intrinsic capacity: results from the ELSI-Brazil study Open
OBJECTIVE To investigate associations among race/color, gender, and intrinsic capacity (IC) (total and by domains) in middle-aged and older adults from a Brazilian cohort. As a secondary objective, we investigate these associations across …
View article: Associations between social connections and cognition: a global collaborative individual participant data meta-analysis
Associations between social connections and cognition: a global collaborative individual participant data meta-analysis Open
View article: Cohort Profile: The Brazilian Longitudinal Study of Ageing (ELSI-Brazil)
Cohort Profile: The Brazilian Longitudinal Study of Ageing (ELSI-Brazil) Open
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Programa de Pós-Graduação em Saúde Pública. Belo Horizonte, MG, Brazil.
View article: Table of Contents
Table of Contents Open
View article: Dose‐response relationship between late‐life physical activity and incident dementia: A pooled analysis of 10 cohort studies of memory in an international consortium
Dose‐response relationship between late‐life physical activity and incident dementia: A pooled analysis of 10 cohort studies of memory in an international consortium Open
Introduction Though consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear. Methods We harmonized longitudinal data of 11,988 participants from 10 cohorts …
View article: Cognitive Frailty is Associated With Elevated Proinflammatory Markers and a Higher Risk of Mortality
Cognitive Frailty is Associated With Elevated Proinflammatory Markers and a Higher Risk of Mortality Open
View article: Prevalence of psychiatric symptoms and associated factors in the adult population from the area affected by the tailings dam rupture – Brumadinho Health Project
Prevalence of psychiatric symptoms and associated factors in the adult population from the area affected by the tailings dam rupture – Brumadinho Health Project Open
Objective: To examine the prevalence of psychiatric symptoms and associated factors in the adult population of Brumadinho (MG), after the dam collapse. Methods: We included 2,740 participants with information about symptoms of post-traumat…
View article: Prevalência de sintomas psiquiátricos e seus fatores associados na população adulta da área atingida pelo rompimento da barragem de rejeitos: Projeto Saúde Brumadinho
Prevalência de sintomas psiquiátricos e seus fatores associados na população adulta da área atingida pelo rompimento da barragem de rejeitos: Projeto Saúde Brumadinho Open
RESUMO: Objetivo: Examinar a prevalência dos sintomas psiquiátricos e seus fatores associados na população adulta de Brumadinho (MG), após o rompimento da barragem. Métodos: Foram incluídos 2.740 participantes com informações coletadas em …
View article: Association of the volume, duration, and intensity of physical activity with incident dementia: A COSMIC collaborative cohort study
Association of the volume, duration, and intensity of physical activity with incident dementia: A COSMIC collaborative cohort study Open
Background Consistent evidence suggested that physical activity (PA) may delay dementia onset. However, the dose‐response association between PA and dementia remains unclear. This study aimed to examine the association between the volume, …
View article: Editorial: Cognitive Impairment and Inflammation in Old Age and the Role of Modifiable Risk Factors of Neurocognitive Disorders
Editorial: Cognitive Impairment and Inflammation in Old Age and the Role of Modifiable Risk Factors of Neurocognitive Disorders Open
So far, numerous functional and structural modifications related to normal brain aging have been reported and indicated that brain mass decreases in the order of 2%-3% per decade after the age of 50, and in subjects 80 years or older, brai…
View article: Does parity matter in women’s risk of dementia? A COSMIC collaboration cohort study
Does parity matter in women’s risk of dementia? A COSMIC collaboration cohort study Open
Background Dementia shows sex difference in its epidemiology. Childbirth, a distinctive experience of women, is associated with the risk for various diseases. However, its association with the risk of dementia in women has rarely been stud…
View article: Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment
Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment Open
View article: Mild and moderate cognitive impairment and mortality among Brazilian older adults in long-term follow-up: The Bambui Health Aging Study
Mild and moderate cognitive impairment and mortality among Brazilian older adults in long-term follow-up: The Bambui Health Aging Study Open
The findings suggest an association between moderate cognitive impairment and all-cause mortality in men in a large Brazilian cohort of older adults.
View article: APOE ε4 and the Influence of Sex, Age, Vascular Risk Factors, and Ethnicity on Cognitive Decline
APOE ε4 and the Influence of Sex, Age, Vascular Risk Factors, and Ethnicity on Cognitive Decline Open
We aimed to examine the relationship between Apolipoprotein E ε4 (APOE*4) carriage on cognitive decline, and whether these associations were moderated by sex, baseline age, ethnicity, and vascular risk factors. Participants were 19,225 ind…