Eduardo I. Cardenas
YOU?
Author Swipe
View article: Incidence and Survival of IDH-Wildtype Glioblastoma and IDH-Mutant Astrocytoma by Treatment and Sex: A Regional Study in Spain (2011–2021)
Incidence and Survival of IDH-Wildtype Glioblastoma and IDH-Mutant Astrocytoma by Treatment and Sex: A Regional Study in Spain (2011–2021) Open
Background: The incidence and prognosis of high-grade gliomas differ according to histopathological and molecular features. The WHO 2021 CNS classification emphasized IDH status, but historical cohorts often lacked systematic molecular pro…
View article: Subcutaneous Allergen‐Specific Immunotherapy for Allergic Rhinitis: Divergent IgA Responses in Nasal Mucosa and Blood With Validation of B Cell Class‐Switching in Lymph Nodes and Blood
Subcutaneous Allergen‐Specific Immunotherapy for Allergic Rhinitis: Divergent IgA Responses in Nasal Mucosa and Blood With Validation of B Cell Class‐Switching in Lymph Nodes and Blood Open
Background Subcutaneous immunotherapy (SCIT) has been a cornerstone treatment for allergic rhinitis (AR) for over 50 years, consistently demonstrating symptom reduction and modulation of immune responses. Despite this, the underlying mecha…
View article: CD18 and CD36 expression in neutrophils from tumors and tumor-draining lymph nodes: implications for metastasis in oral squamous cell carcinoma
CD18 and CD36 expression in neutrophils from tumors and tumor-draining lymph nodes: implications for metastasis in oral squamous cell carcinoma Open
Background Neutrophil infiltration in tumors and tumor-draining lymph nodes (TDLNs) influences oral squamous cell carcinoma (OSCC) progression and metastasis. Neutrophils can exhibit an immunosuppressive phenotype, with CD18 and CD36 poten…
View article: Serum proteomics links the cardiorespiratory biomarkers CTRC, OSM, and MMP-10 to exacerbation severity and number in patients with COPD
Serum proteomics links the cardiorespiratory biomarkers CTRC, OSM, and MMP-10 to exacerbation severity and number in patients with COPD Open
During exacerbations, patients with chronic obstructive pulmonary disease (COPD) are at risk for severe cardiovascular disease (CVD). Despite this, the available literature on systemic biomarkers of CVD during exacerbations is limited. In …
View article: Nasal production of IL-26 involving T cells in smokers with and without chronic obstructive pulmonary disease
Nasal production of IL-26 involving T cells in smokers with and without chronic obstructive pulmonary disease Open
In the nasal cavity, IL-26 can be produced by local T cells. This IL-26 reflects bronchoalveolar pathology and clinical symptoms, thereby constituting an accessible target with potential for clinically relevant endotyping in COPD.
View article: Determinación de parasitosis intestinal en niños de preescolar en Barquisimeto, estado Lara.
Determinación de parasitosis intestinal en niños de preescolar en Barquisimeto, estado Lara. Open
Introducción: La parasitosis intestinal es un problema de salud pública que algunos investigadores afirman que se ve favorecido por la falta de servicios básicos; por ello, se decidió estudiar la parasitosis intestinal en niños de 3 a 6 añ…
View article: Mast cell populations shift and adapt transcription profiles during the resolution of allergic airway inflammation
Mast cell populations shift and adapt transcription profiles during the resolution of allergic airway inflammation Open
Asthma is a chronic lung disease characterized by recurrent acute inflammation and periods of resolution. To determine whether inflammation-induced lung mast cell (MC) populations persist or undergo phenotypic shifts during the resolution …
View article: Systemic increase in IL-26 is associated with severe COVID-19 and comorbid obstructive lung disease
Systemic increase in IL-26 is associated with severe COVID-19 and comorbid obstructive lung disease Open
Background IL-26 is a key mediator of pulmonary host defense given its abundant expression in human airways and its established antibacterial properties. Moreover, recent studies indicate that IL-26 can also inhibit viral replication. Alon…
View article: Delayed neutrophil shedding of CD62L in patients with chronic rhinosinusitis with nasal polyps and asthma: Implications for <i>Staphylococcus aureus</i> colonization and corticosteroid treatment
Delayed neutrophil shedding of CD62L in patients with chronic rhinosinusitis with nasal polyps and asthma: Implications for <i>Staphylococcus aureus</i> colonization and corticosteroid treatment Open
Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory disease of the sinonasal mucosa that is often accompanied by local Staphylococcus aureus colonization,1 as well as comorbid asthma.2 Although both CRSwNP and asthma are a…
View article: TLR4-mediated release of heparin-binding protein in human airways: a co-stimulatory role for IL-26
TLR4-mediated release of heparin-binding protein in human airways: a co-stimulatory role for IL-26 Open
Background Bacterial infection causes accumulation of neutrophils that release antimicrobial proteins including heparin-binding protein (HBP). In human airways, this neutrophil accumulation can be re-capitulated via intrabronchial exposure…
View article: Depletion of Mcpt8‐expressing cells reduces lung mast cells in mice with experimental asthma
Depletion of Mcpt8‐expressing cells reduces lung mast cells in mice with experimental asthma Open
Genetically engineered mouse models have exploited the basophil marker mast cell protease-8 (mMCP-8) to dissect the role of basophils in inflammatory diseases.1-3 However, mast cell progenitors (MCps) also express Mcpt8 transcripts in the …
View article: Increased IL-26 associates with markers of hyperinflammation and tissue damage in patients with acute COVID-19
Increased IL-26 associates with markers of hyperinflammation and tissue damage in patients with acute COVID-19 Open
Interleukin-26 (IL-26) is released by several immune and structural cells following stimulation of toll-like receptors (TLRs), whereupon it can directly inhibit viral replication and enhance neutrophil chemotaxis. Given these unique proper…
View article: SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion
SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion Open
The corona virus (SARS-CoV-2) pandemic and the resulting long-term neurological complications in patients, known as long COVID, have renewed the interest in the correlation between viral infections and neurodegenerative brain disorders. Wh…
View article: Elastase- and LPS-Exposed Cpa3Cre/+ and ST2-/- Mice Develop Unimpaired Obstructive Pulmonary Disease
Elastase- and LPS-Exposed Cpa3Cre/+ and ST2-/- Mice Develop Unimpaired Obstructive Pulmonary Disease Open
IL-33 and its receptor ST2, as well as mast cells and their mediators, have been implicated in the development of chronic obstructive pulmonary disease (COPD). However, whether mast cells and the ST2 receptor play a critical role in COPD p…
View article: The Proportion of FceRI+ Blood Monocytes Increases With the Degree of IgE-Mediated Sensitization in Asthma
The Proportion of FceRI+ Blood Monocytes Increases With the Degree of IgE-Mediated Sensitization in Asthma Open
Study participantsThe study included 67 individuals between 15-41 years old in a 3-5 year follow-up of the MIDAS cohort (Minimally Invasive Diagnostic Procedures in Allergy, Asthma, or Food hypersensitivity), MIDASII.Data from MIDASII have…
View article: IL-26 in asthma and COPD
IL-26 in asthma and COPD Open
IL-26 constitutes a potential target for diagnostic purposes and therapeutic modulation of the innate immune response in the airways of patients with asthma and COPD. It seems reasonable to expect more conclusive evidence of its clinical u…
View article: SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis
SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis Open
View article: Author Index
Author Index Open
View article: Munc18-2, but not Munc18-1 or Munc18-3, regulates platelet exocytosis, hemostasis, and thrombosis
Munc18-2, but not Munc18-1 or Munc18-3, regulates platelet exocytosis, hemostasis, and thrombosis Open
Platelet degranulation, a form of regulated exocytosis, is crucial for hemostasis and thrombosis. Exocytosis in platelets is mediated by SNARE proteins, and in most mammalian cells this process is controlled by Munc18 (mammalian homolog of…
View article: Platelet Munc13-4 regulates hemostasis, thrombosis and airway inflammation
Platelet Munc13-4 regulates hemostasis, thrombosis and airway inflammation Open
Platelet degranulation is crucial for hemostasis and may participate in inflammation. Exocytosis in platelets is mediated by SNARE proteins and should be controlled by Munc13 proteins. We found that platelets express Munc13-2 and -4. We as…
View article: Munc13 proteins control regulated exocytosis in mast cells
Munc13 proteins control regulated exocytosis in mast cells Open
View article: Bupropion
Bupropion Open
View article: Rosiglitazona
Rosiglitazona Open
View article: Levofloxacino. Experiencia clínica en tratamientos de larga duración de infecciones osteoarticulares
Levofloxacino. Experiencia clínica en tratamientos de larga duración de infecciones osteoarticulares Open
Se ha realizado un estudio con el fin de evaluar la eficacia y la tolerancia de la administración de larga duración de levofloxacino en el tratamiento de infecciones osteoarticulares. Se incluyeron 50 pacientes con una previsión inicial de…
View article: Control of Mast Cell Regulated Exocytosis by Munc13 Proteins
Control of Mast Cell Regulated Exocytosis by Munc13 Proteins Open
Mast cells (MCs) are involved in pathogen defense and inflammatory reactions. Upon stimulation, they release substances stored in their granules via regulated exocytosis. In other cell types, Munc13 proteins play essential roles in regulat…
View article: Celecoxib
Celecoxib Open
Cclccoxib cs un nuevo AlNl~i que, gracias a su mayor espedficiciad dc acción, manticnc las propiedades atialgésicas y antipiséticas que caracterizan a estc gsupo de fárinacos reduciendo los efectos adversos, sobre todo de tipo gastrointcst…