Eduardo J. Contijoch
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View article: Defined microbiota transplant restores Th17/RORγt <sup>+</sup> regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas
Defined microbiota transplant restores Th17/RORγt <sup>+</sup> regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas Open
Significance Composition of gut microbiota is altered in many human diseases, including inflammatory bowel disease. Some hope that restoring microbiota to a healthy state could help treat such diseases. We have used mice colonized with mic…
View article: Fecal IgA Levels Are Determined by Strain-Level Differences in Bacteroides ovatus and Are Modifiable by Gut Microbiota Manipulation
Fecal IgA Levels Are Determined by Strain-Level Differences in Bacteroides ovatus and Are Modifiable by Gut Microbiota Manipulation Open
View article: Defined microbiota transplant restores Th17/RORγt<sup>+</sup> regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas
Defined microbiota transplant restores Th17/RORγt<sup>+</sup> regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas Open
The building evidence for the contribution of microbiota to human disease has spurred an effort to develop therapies that target the gut microbiota. This is particularly evident in inflammatory bowel diseases, where clinical trials of feca…
View article: Microbial Engraftment and Efficacy of Fecal Microbiota Transplant for Clostridium Difficile in Patients With and Without Inflammatory Bowel Disease
Microbial Engraftment and Efficacy of Fecal Microbiota Transplant for Clostridium Difficile in Patients With and Without Inflammatory Bowel Disease Open
Inflammatory bowel disease did not affect CDI recurrence rates 6 months after FMT. Pre-FMT microbiota was not predictive of recurrence, and microbial engraftment was impacted in those requiring IBD treatment escalation, though not by CDI r…
View article: Strain-level differences in gut microbiome composition determine fecal IgA levels and are modifiable by gut microbiota manipulation
Strain-level differences in gut microbiome composition determine fecal IgA levels and are modifiable by gut microbiota manipulation Open
Fecal IgA production depends on colonization by a gut microbiota. However, the bacterial strains that drive gut IgA production remain largely unknown. By accessing the IgA-inducing capacity of a diverse set of human gut microbial strains, …
View article: Gut microbiota density influences host physiology and is shaped by host and microbial factors
Gut microbiota density influences host physiology and is shaped by host and microbial factors Open
To identify factors that regulate gut microbiota density and the impact of varied microbiota density on health, we assayed this fundamental ecosystem property in fecal samples across mammals, human disease, and therapeutic interventions. P…
View article: Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice
Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice Open
View article: Author response: Gut microbiota density influences host physiology and is shaped by host and microbial factors
Author response: Gut microbiota density influences host physiology and is shaped by host and microbial factors Open
View article: Gut microbiota density influences host physiology and is shaped by host and microbial factors
Gut microbiota density influences host physiology and is shaped by host and microbial factors Open
Summary To identify factors that regulate gut microbiota density and the impact of varied microbiota density on health, we assayed this fundamental ecosystem property in fecal samples across mammals, human disease, and therapeutic interven…
View article: Inflammatory bowel disease microbiotas alter gut CD4 T-cell homeostasis and drive colitis in mice
Inflammatory bowel disease microbiotas alter gut CD4 T-cell homeostasis and drive colitis in mice Open
To examine the functional contribution of Inflammatory Bowel Disease (IBD) microbes to immune homeostasis and colitis, we colonized unchallenged and colitis-susceptible germ-free mice with over twenty human intestinal microbiotas from heal…
View article: Microbial Engraftment and Efficacy of Fecal Microbiota Transplant for <i>Clostridium difficile</i> Patients With and Without IBD
Microbial Engraftment and Efficacy of Fecal Microbiota Transplant for <i>Clostridium difficile</i> Patients With and Without IBD Open
Background & Aims Recurrent and refractory Clostridium difficile infections (CDI) are effectively treated with fecal microbiota transplant (FMT). Uncertainty exists regarding the effectiveness of FMT for CDI with underlying inflammatory bo…
View article: Data Related to: Gut microbiota density influences host physiology and is shaped by host and microbial factors
Data Related to: Gut microbiota density influences host physiology and is shaped by host and microbial factors Open
Data accompanying the manuscript entitled "Gut microbiota density influences host physiology and is shaped by host and microbial factors". This data repository includes the flow cytometry data for antibiotic-treated mouse experiments. Any …
View article: Interactions Between Diet and the Intestinal Microbiota Alter Intestinal Permeability and Colitis Severity in Mice
Interactions Between Diet and the Intestinal Microbiota Alter Intestinal Permeability and Colitis Severity in Mice Open
View article: Deciphering the combinatorial influence of diet and the microbiota on experimental colitis
Deciphering the combinatorial influence of diet and the microbiota on experimental colitis Open
Background & Aims The complex interactions between diet and the microbiota that influence mucosal inflammation and inflammatory bowel disease are poorly understood. Experimental colitis models provide the opportunity to control and systema…