Eduardo J. M. Nascimento
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View article: Zika Virus Neutralizing Antibody Responses Elicited by Vaccination or Infection
Zika Virus Neutralizing Antibody Responses Elicited by Vaccination or Infection Open
Background Zika virus (ZIKV) emergence in 2015–2016 was characterized by high attack rates and a wave of Congenital Zika Syndrome cases that affected several countries in the Americas. The sudden drop in virus transmission in the following…
View article: SURGICAL APPROACH IN PATIENTS WITH CATASTROPHIC ABDOMEN
SURGICAL APPROACH IN PATIENTS WITH CATASTROPHIC ABDOMEN Open
Catastrophic abdomen, characterized by severe abdominal dysfunction due to trauma, infection or surgical complications, represents one of the greatest challenges in emergency surgery. The condition requires rapid and effective intervention…
View article: IMPACT OF THE USE OF SOCIAL NETWORKS ON THE DEVELOPMENT OF ANXIETY AND DEPRESSION DISORDERS IN YOUNG ADULTS
IMPACT OF THE USE OF SOCIAL NETWORKS ON THE DEVELOPMENT OF ANXIETY AND DEPRESSION DISORDERS IN YOUNG ADULTS Open
Social networks have transformed the way young adults relate, consume information and construct their identities. Although these platforms provide opportunities for connection and learning, their excessive use has been associated with the …
View article: P-18 ANTI-HBC POSITIVITY IS AN INDEPENDENT PREDICTIVE FACTOR FOR HCC DEVELOPMENT AND SHOULD BE INCORPORATED TO THE HCC RISK SCORE PREDICTION MODEL IN ADVANCED FIBROSIS
P-18 ANTI-HBC POSITIVITY IS AN INDEPENDENT PREDICTIVE FACTOR FOR HCC DEVELOPMENT AND SHOULD BE INCORPORATED TO THE HCC RISK SCORE PREDICTION MODEL IN ADVANCED FIBROSIS Open
Conflict of interest: No Introduction and Objectives: After hepatitis C virus (HCV) treatment with direct-acting antivirals (DAAs), the sustained viral response increased to 95%, although it may be lower in advanced fibrosis. Continuous fo…
View article: Antibodies Produced in Response to a Live-Attenuated Dengue Vaccine Are Functional in Activating the Complement System
Antibodies Produced in Response to a Live-Attenuated Dengue Vaccine Are Functional in Activating the Complement System Open
Background Antibody-driven complement system (CS) activation has been associated with protection against symptomatic dengue virus (DENV) infection. Aggregation, opsonization, lysis, and phagocytosis are mechanisms triggered by antibody-ant…
View article: Development and Characterization of a Multiplex Assay to Quantify Complement-Fixing Antibodies against Dengue Virus
Development and Characterization of a Multiplex Assay to Quantify Complement-Fixing Antibodies against Dengue Virus Open
Antibodies capable of activating the complement system (CS) when bound with antigen are referred to as “complement-fixing antibodies” and are involved in protection against Flaviviruses. A complement-fixing antibody test has been used in t…
View article: 1051. Characterization of Immune Responses to a Live-Attenuated Tetravalent Dengue Vaccine
1051. Characterization of Immune Responses to a Live-Attenuated Tetravalent Dengue Vaccine Open
Background A safe and effective vaccine against dengue is needed to address an unmet medical need that affects a large portion of the world’s population. Takeda’s live attenuated tetravalent dengue vaccine candidate (TAK-003) has shown pro…
View article: Risk of Sexually Transmitted Zika Virus in a Cohort of Economically Disadvantaged Urban Residents
Risk of Sexually Transmitted Zika Virus in a Cohort of Economically Disadvantaged Urban Residents Open
To understand the disease burden of sexually transmitted Zika virus (ZIKV), we prospectively followed a cohort of 359 adult and adolescent residents of an urban community in Salvador, Brazil, through the 2015 ZIKV epidemic. Later, in 2017,…
View article: Impact of dengue virus genetic diversity on breadth of neutralization by a tetravalent dengue vaccine
Impact of dengue virus genetic diversity on breadth of neutralization by a tetravalent dengue vaccine Open
Background: Extraordinary genetic diversity is a hallmark of dengue virus (DENV), with different genotypes within each of the four DENV serotypes capable of causing disease. The virus envelope (E) plays a critical role in the virus life cy…
View article: Use of a Blockade-of-Binding ELISA and Microneutralization Assay to Evaluate Zika Virus Serostatus in Dengue-Endemic Areas
Use of a Blockade-of-Binding ELISA and Microneutralization Assay to Evaluate Zika Virus Serostatus in Dengue-Endemic Areas Open
Zika virus (ZIKV) serological diagnostics are compromised in areas where dengue viruses (DENV) co-circulate because of their high levels of protein sequence homology. Here, we describe the characterization of a Zika blockade-of-binding ELI…
View article: Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region
Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region Open
Zika dynamics in South America The infection dynamics of Zika virus (ZIKV) are difficult to characterize. Many ZIKV infections are asymptomatic, and the clinical presentation of ZIKV is nonspecific. Rodriguez-Barraquer et al. took advantag…
View article: Detection of IgG3 antibodies specific to the human immunodeficiency virus type 1 (HIV-1) p24 protein as marker for recently acquired infection
Detection of IgG3 antibodies specific to the human immunodeficiency virus type 1 (HIV-1) p24 protein as marker for recently acquired infection Open
Reducing the risk of human immunodeficiency virus type 1 (HIV-1) transmission is still a public health priority. The development of effective control strategies relies on the quantification of the effects of prophylactic and therapeutic me…
View article: Development of antibody biomarkers of long term and recent dengue virus infections
Development of antibody biomarkers of long term and recent dengue virus infections Open
Dengue virus (DENV) infections elicit antibody responses to the non-structural protein 1 (NS1) that are associated with protection against disease. However, the antibody isotypes and subclasses involved, and their kinetics have not been ex…
View article: Development of an anti-dengue NS1 IgG ELISA to evaluate exposure to dengue virus
Development of an anti-dengue NS1 IgG ELISA to evaluate exposure to dengue virus Open
Dengue virus infection elicits immune responses to multiple viral antigens including antibodies to dengue non-structural protein 1 (NS1) which are rapidly induced and detected within days of infection. The recombinant, live, attenuated, te…
View article: Dengue virus (DENV)-specific antibodies enhance Brazilian Zika virus (ZIKV) infection
Dengue virus (DENV)-specific antibodies enhance Brazilian Zika virus (ZIKV) infection Open
Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We demonstrate that dengue-specific antibodies enhance the infection of a prima…
View article: Placental Transfer of Dengue Virus (DENV)–Specific Antibodies and Kinetics of DENV Infection–Enhancing Activity in Brazilian Infants
Placental Transfer of Dengue Virus (DENV)–Specific Antibodies and Kinetics of DENV Infection–Enhancing Activity in Brazilian Infants Open
Unlike Asian infants, the enhancing activity of DENV infection by maternally transferred DENV antibodies occurs at earlier ages in Brazilian children. These findings might explain the low occurrence of severe dengue among infants in our se…