Edvaldo da Silva Trindade
YOU?
Author Swipe
View article: Davanat-Mimetic Galactomannan and Its Sulfated Derivative: Structure and Antitumor Effects against Melanoma
Davanat-Mimetic Galactomannan and Its Sulfated Derivative: Structure and Antitumor Effects against Melanoma Open
Melanoma is the most aggressive skin cancer, with a high metastatic potential and limited treatment options in advanced stages. Polysaccharides are promising antitumor agents, and therefore, this study investigated a galactomannan from gua…
View article: 3D scaffold of hydroxyapatite/β tricalcium phosphate from mussel shells: Synthesis, characterization and cytotoxicity
3D scaffold of hydroxyapatite/β tricalcium phosphate from mussel shells: Synthesis, characterization and cytotoxicity Open
We produced promising HA/β-TCP bioceramics with characteristics that allowed cell culture, promoting adhesion, spreading, and proliferation.
View article: Sugarcane: an unexpected habitat for black yeasts in Chaetothyriales
Sugarcane: an unexpected habitat for black yeasts in Chaetothyriales Open
Sugarcane ( Saccharum officinarum , Poaceae ) is cultivated on a large scale in (sub)tropical regions such as Brazil and has considerable economic value for sugar and biofuel production. The plant is a rich substrate for endo- and epiphyti…
View article: Unexpected Results with New Homeopathic Complexes: A Review
Unexpected Results with New Homeopathic Complexes: A Review Open
Despite homeopathy being a therapy that has been around for over 200 years, it still arouses controversy, both because of the high dilutions in which it is administered and because of the methodologies used in research, which are not alway…
View article: Recent Advances in Alternative Medicine
Recent Advances in Alternative Medicine Open
Modern medicine tends to favor treatment with pharmaceuticals. However, there is a growing trend towards personalized and holistic medicine that incorporates a person’s biopsychosocial and spiritual perspective. This book discusses some of…
View article: Lnc-uc.147 Is Associated with Disease Stage of Liver, Gastric, and Renal Cancer
Lnc-uc.147 Is Associated with Disease Stage of Liver, Gastric, and Renal Cancer Open
Lnc-uc.147, a long non-coding RNA derived from a transcribed ultraconserved region (T-UCR), was previously evidenced in breast cancer. However, the role of this region in other tumor types was not previously investigated. The present study…
View article: Infection of SARS-CoV-2 in domestic dogs associated with owner viral load
Infection of SARS-CoV-2 in domestic dogs associated with owner viral load Open
View article: MG-Pe: A Novel Galectin-3 Ligand with Antimelanoma Properties and Adjuvant Effects to Dacarbazine
MG-Pe: A Novel Galectin-3 Ligand with Antimelanoma Properties and Adjuvant Effects to Dacarbazine Open
Melanoma is a highly metastatic and rapidly progressing cancer, a leading cause of mortality among skin cancers. The melanoma microenvironment, formed from the activity of malignant cells on the extracellular matrix and the recruitment of …
View article: SARS-CoV-2 Delta and Omicron Variants Surge in Curitiba, Southern Brazil, and Its Impact on Overall COVID-19 Lethality
SARS-CoV-2 Delta and Omicron Variants Surge in Curitiba, Southern Brazil, and Its Impact on Overall COVID-19 Lethality Open
Screening efforts and genomic surveillance are essential tools to evaluate the course of the COVID-19 pandemic and assist the public healthcare system in dealing with an increasing number of infections. For the analysis of COVID-19 cases s…
View article: In vivo treatment with M8, a highly diluted tinctures complex, reduced the malignancy of a mouse melanoma model
In vivo treatment with M8, a highly diluted tinctures complex, reduced the malignancy of a mouse melanoma model Open
Background: Cancer is a class of disease responsible for 13% of death cause worldwide. Among all types of cancers, one of the most aggressive and with the highest death rate is melanoma. It is highly metastatic and current treatments with …
View article: Highly diluted compounds effects on B16-F10 melanogenesis, reactive oxygen species (ROS) production and tumorigenesis.
Highly diluted compounds effects on B16-F10 melanogenesis, reactive oxygen species (ROS) production and tumorigenesis. Open
Background: Cutaneous melanoma is a highly malignant tumor derived from pigment-producing (melanin) melanocytes of skin epidermis. Cutaneous pigmentation is described as the major physiologic defense against UV radiation. During melanin bi…
View article: Large-Scale Screening of Asymptomatic Persons for SARS-CoV-2 Variants of Concern and Gamma Takeover, Brazil
Large-Scale Screening of Asymptomatic Persons for SARS-CoV-2 Variants of Concern and Gamma Takeover, Brazil Open
We performed a large-scale severe acute respiratory syndrome coronavirus 2 screening campaign using 2 PCR-based approaches, coupled with variant genotyping, aiming to provide a safer environment for employees of Federal University in Curit…
View article: BDE-209 Becreases the Efficacy of Dacarbazine Treatment for Melanoma in C57BL/6 Mice
BDE-209 Becreases the Efficacy of Dacarbazine Treatment for Melanoma in C57BL/6 Mice Open
Humans are widely exposed to environmental chemical toxicants potentially related to disease susceptibility. Polybrominated diphenyl ethers (PBDEs) present a proven risk associated with cancer, but no studies are related with the tumor pro…
View article: in vivo results of laboratory tests with a homeopathic complex (M1)
in vivo results of laboratory tests with a homeopathic complex (M1) Open
Over the past years our research group has been testing the action of highly diluted substances and tinctures on cells from the immune system. The development of new combinations was based on laboratorial tests and assays were performed in…
View article: Metastatic melanoma cells are selective affected in vitro by Atropa belladonna 200 c.
Metastatic melanoma cells are selective affected in vitro by Atropa belladonna 200 c. Open
Background: Cancers are among the top 10 causes of death worldwide. Melanoma is a skin cancer originated from mutations on melanocytes. Transformed melanocytes can migrate and invade tissues in a process called metastasis. When early diagn…
View article: Large-scale screening of asymptomatic for SARS-CoV-2 variants of concern and rapid P.1 takeover, Curitiba, Brazil
Large-scale screening of asymptomatic for SARS-CoV-2 variants of concern and rapid P.1 takeover, Curitiba, Brazil Open
To provide a safer environment for individuals working on-site at the Federal University of Paraná, Curitiba, Brazil, we performed a large-scale mass testing SARS-CoV-2 program coupled with variant genotyping using two PCR-based approaches…
View article: Agrobacterium tumefaciens-Mediated Transformation of Fonsecaea monophora and Fonsecaea erecta for Host-Environment Interaction Studies
Agrobacterium tumefaciens-Mediated Transformation of Fonsecaea monophora and Fonsecaea erecta for Host-Environment Interaction Studies Open
The fungal genus Fonsecaea contains etiological agents of human chromoblastomycosis, a (sub)tropical, (sub)cutaneous implantation disease caused by plant contact. The invasive potential differs significantly between species. Infections by …
View article: CORRELAÇÃO ENTRE PÚRPURA TROMBOCITOPÊNICA IDIOPÁTICA E A BACTÉRIA HELICOBACTER PYLORI
CORRELAÇÃO ENTRE PÚRPURA TROMBOCITOPÊNICA IDIOPÁTICA E A BACTÉRIA HELICOBACTER PYLORI Open
View article: Beyond gold nanoparticles cytotoxicity: Potential to impair metastasis hallmarks
Beyond gold nanoparticles cytotoxicity: Potential to impair metastasis hallmarks Open
View article: The Antitumor Effect of Heparin is not Mediated by Direct NK Cell Activation
The Antitumor Effect of Heparin is not Mediated by Direct NK Cell Activation Open
Natural killer (NK) cells are innate lymphocytes responsible for the elimination of infected or transformed cells. The activation or inhibition of NK cells is determined by the balance of target cell ligand recognition by stimulatory and i…
View article: Immune-mediated febrile response in female rats: Role of central hypothalamic mediators
Immune-mediated febrile response in female rats: Role of central hypothalamic mediators Open
Lipopolysaccharide (LPS) induces fever through cytokines like receptor-activator of nuclear factor κB ligand (RANKL), triggering mediators like prostaglandins (PG), endothelin-1 (ET-1), corticotrophin-releasing factor (CRF), substance P (S…
View article: Tumor Microenvironment-Associated Extracellular Matrix Components Regulate NK Cell Function
Tumor Microenvironment-Associated Extracellular Matrix Components Regulate NK Cell Function Open
The tumor microenvironment (TME) is composed of multiple infiltrating host cells (e.g., endothelial cells, fibroblasts, lymphocytes, and myeloid cells), extracellular matrix, and various secreted or cell membrane-presented molecules. Group…
View article: The alternatively spliced RECK transcript variant 3 is a predictor of poor survival for melanoma patients being upregulated in aggressive cell lines and modulating MMP gene expression in vitro
The alternatively spliced RECK transcript variant 3 is a predictor of poor survival for melanoma patients being upregulated in aggressive cell lines and modulating MMP gene expression in vitro Open
The reversion-inducing cysteine-rich protein with kazal motifs ( RECK ) gene was described as a tumor suppressor gene two decades ago. Recently, novel alternatively spliced products of this gene have been identified. Of these, the transcri…
View article: Absence of a synergic nigral proapoptotic effect triggered by REM sleep deprivation in the rotenone model of Parkinson´s disease
Absence of a synergic nigral proapoptotic effect triggered by REM sleep deprivation in the rotenone model of Parkinson´s disease Open
Excitotoxicity has been related to play a crucial role in Parkinson's disease (PD) pathogenesis. Pedunculopontine tegmental nucleus (PPT) represents one of the major sources of glutamatergic afferences to nigrostriatal pathway and putative…
View article: Structure elucidation of a bioactive fucomannogalactan from the edible mushroom Hypsizygus marmoreus
Structure elucidation of a bioactive fucomannogalactan from the edible mushroom Hypsizygus marmoreus Open
View article: In vitro attenuation of classic metastatic melanoma‑related features by highly diluted natural complexes: Molecular and functional analyses
In vitro attenuation of classic metastatic melanoma‑related features by highly diluted natural complexes: Molecular and functional analyses Open
Metastasis is responsible for the majority of deaths among patients with malignant melanoma. Despite recent advances, the majority of current and modern therapies are ineffective and/or financially unfeasible. Thus, in this study, we inves…
View article: Anti-Thrombin, Anti-Adhesive, Anti-Migratory, and Anti-Proliferative Activities of Sulfated Galactans from the Tropical Green Seaweed, Udotea flabellum
Anti-Thrombin, Anti-Adhesive, Anti-Migratory, and Anti-Proliferative Activities of Sulfated Galactans from the Tropical Green Seaweed, Udotea flabellum Open
In this study, sulfated polysaccharide-rich extracts were isolated from 22 tropical seaweeds (4 red, 11 brown, and 7 green) found in northeastern Brazil, and evaluated for the role of anticoagulant agents. Fifteen of the extracts showed an…
View article: A Model for Trans-Kingdom Pathogenicity in Fonsecaea Agents of Human Chromoblastomycosis
A Model for Trans-Kingdom Pathogenicity in Fonsecaea Agents of Human Chromoblastomycosis Open
The fungal genus Fonsecaea comprises etiological agents of human chromoblastomycosis, a chronic implantation skin disease. The current hypothesis is that patients acquire the infection through an injury from plant material. The pres…
View article: A low-molecular-weight galactofucan from the seaweed, Spatoglossum schröederi, binds fibronectin and inhibits capillary-like tube formation in vitro
A low-molecular-weight galactofucan from the seaweed, Spatoglossum schröederi, binds fibronectin and inhibits capillary-like tube formation in vitro Open
View article: Antibacterial, Antiproliferative, and Immunomodulatory Activity of Silver Nanoparticles Synthesized with Fucans from the Alga Dictyota mertensii
Antibacterial, Antiproliferative, and Immunomodulatory Activity of Silver Nanoparticles Synthesized with Fucans from the Alga Dictyota mertensii Open
In this study, we aimed to synthesize silver nanoparticles containing fucans from Dictyota mertensii (Martius) Kützing using an environmentally friendly method and to characterize their structure as well as antiproliferative, immunomodulat…