Explanipedia

cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression Open

Ying Wang, Deng‐Guang Yu, Jianfeng Chen, Quentin Hahn, David S. Umbaugh , et al. · 2025

Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor essential for host defense against microbial infections, but its role beyond innate immunity remains unclear. Here, a non-canonical function of cGAS in regulating aldehyde metabolism…

cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression Open

Ying Wang, Yu Deng, Jianfeng Chen, Quentin Hahn, David S. Umbaugh , et al. · 2025

Cyclic GMP‐AMP synthase (cGAS) is a cytosolic DNA sensor essential for host defense against microbial infections, but its role beyond innate immunity remains unclear. Here, a non‐canonical function of cGAS in regulating aldehyde metabolism…

eLife Assessment: An in vitro human vessel model to study Neisseria meningitidis colonization and vascular damages Open

Edward A. Miao · 2025

A gut sense for a microbial pattern regulates feeding Open

Winston Liu, Naama Reicher, Emily Alway, Laura E. Rupprecht, Peter Weng , et al. · 2025

To coexist with its resident microorganisms, the host must have a sense to adjust its behaviour in response to them. In the intestine, a sense for nutrients transduced to the brain through neuroepithelial circuits guides appetitive choices…

The NLRP1 inflammasome is an essential and selective mediator of axon pruning in neurons Open

Selena E. Romero, Matthew J Geden, Richa Basundra, Kiran Kelly‐Rajan, Edward A. Miao , et al. · 2025

The NLRP1 inflammasome is an essential and selective mediator of axon pruning in neurons Open

Selena E. Romero, Matthew J Geden, Richa Basundra, Kiran Kelly‐Rajan, Edward A. Miao , et al. · 2025

Axon pruning is a unique process neurons utilize to selectively degenerate axon branches while keeping the neuronal cell body intact. The mechanisms of axon pruning have much in common with those of apoptosis. Both axon pruning and apoptos…

Author response: Chemokine expression profile of an innate granuloma Open

Megan E. Amason, Cole J. Beatty, Carissa K. Harvest, Daniel R. Saban, Edward A. Miao · 2024

Chemokine expression profile of an innate granuloma Open

Megan E. Amason, Cole J. Beatty, Carissa K. Harvest, Daniel R. Saban, Edward A. Miao · 2024

Granulomas are defined by the presence of organized layers of immune cells that include macrophages. Granulomas are often characterized as a way for the immune system to contain an infection and prevent its dissemination. We recently estab…

Chemokine expression profile of an innate granuloma Open

Megan E. Amason, Cole J. Beatty, Carissa K. Harvest, Daniel R. Saban, Edward A. Miao · 2024

Granulomas are defined by the presence of organized layers of immune cells that include macrophages. Granulomas are often characterized as a way for the immune system to contain an infection and prevent its dissemination. We recently estab…

The story behind the emergence of different forms of cell death Open

Barbara Conradt, Edward A. Miao, Junying Yuan, Thirumala‐Devi Kanneganti, Brent R. Stockwell , et al. · 2024

Chemokine expression profile of an innate granuloma Open

Megan E. Amason, Cole J. Beatty, Carissa K. Harvest, Daniel R. Saban, Edward A. Miao · 2024

Granulomas are defined by the presence of organized layers of immune cells that include macrophages. Granulomas are often characterized as a way for the immune system to contain an infection and prevent its dissemination. We recently estab…

Author response: Chemokine expression profile of an innate granuloma Open

Megan E. Amason, Cole J. Beatty, Carissa K. Harvest, Daniel R. Saban, Edward A. Miao · 2024

Pseudomonas aeruginosa Mediates Host Necroptosis through Rhl-Pqs Quorum Sensing Interaction Open

Zihao Liu, Lu Sun, Lupeng Li, Edward A. Miao, Amal O. Amer , et al. · 2024

Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen that can cause serious infections in immunocompromised patients. Quorum sensing (QS), a communication system evolved by P. aeruginosa to survey its density, is well acknow…

NLRP3, NLRP6, and NLRP12 are inflammasomes with distinct expression patterns Open

Bo Wei, Zachary P. Billman, Kengo Nozaki, Helen S. Goodridge, Edward A. Miao · 2024

Inflammasomes are sensors that detect cytosolic microbial molecules or cellular damage, and in response they initiate a form of lytic regulated cell death called pyroptosis. Inflammasomes signal via homotypic protein-protein interactions w…

Chemokine expression profile of an innate granuloma Open

Megan E. Amason, Cole J. Beatty, Carissa K. Harvest, Daniel R. Saban, Edward A. Miao · 2024

Granulomas are defined by the presence of organized layers of immune cells that include macrophages. Granulomas are often characterized as a way for the immune system to contain an infection and prevent its dissemination. We recently estab…

Chemokine expression profile of an innate granuloma Open

Megan E. Amason, Carissa K. Harvest, Cole J. Beatty, Daniel R. Saban, Edward A. Miao · 2024

Granulomas are defined by the presence of organized layers of immune cells that include macrophages. Granulomas are often characterized as a way for the immune system to contain an infection and prevent its dissemination. We recently estab…

Reviewer #2 (Public Review): Chemokine expression profile of an innate granuloma Open

Megan E. Amason, Carissa K. Harvest, Cole J. Beatty, Daniel R. Saban, Edward A. Miao · 2024

Granulomas are defined by the presence of organized layers of immune cells that include macrophages. Granulomas are often characterized as a way for the immune system to contain an infection and prevent its dissemination. We recently estab…

Reviewer #1 (Public Review): Chemokine expression profile of an innate granuloma Open

Megan E. Amason, Carissa K. Harvest, Cole J. Beatty, Daniel R. Saban, Edward A. Miao · 2024

Granulomas are defined by the presence of organized layers of immune cells that include macrophages. Granulomas are often characterized as a way for the immune system to contain an infection and prevent its dissemination. We recently estab…

Caspase-1 activates gasdermin A in non-mammals Open

Zachary P. Billman, Stephen B. Kovacs, Bo Wei, Kidong Kang, Ousmane H. Cissé , et al. · 2024

Gasdermins oligomerize to form pores in the cell membrane, causing regulated lytic cell death called pyroptosis. Mammals encode five gasdermins that can trigger pyroptosis: GSDMA, B, C, D, and E. Caspase and granzyme proteases cleave the l…

Author Response: Caspase-1 activates gasdermin A in non-mammals Open

Zachary P. Billman, Stephen B. Kovacs, Bo Wei, Kidong Kang, Ousmane H. Cissé , et al. · 2024

Author Response: Caspase-1 activates gasdermin A in non-mammals Open

Zachary P. Billman, Stephen B. Kovacs, Bo Wei, Kidong Kang, Ousmane H. Cissé , et al. · 2024

Gasdermins oligomerize to form pores in the cell membrane, causing regulated lytic cell death called pyroptosis. Mammals encode five gasdermins that can trigger pyroptosis: GSDMA, B, C, D, and E. Caspase and granzyme proteases cleave the l…

Reviewer #2 (Public Review): Caspase-1 activates gasdermin A in non-mammals Open

Zachary P. Billman, Stephen B. Kovacs, Bo Wei, Kidong Kang, Ousmane H. Cissé , et al. · 2024

Gasdermins oligomerize to form pores in the cell membrane, causing regulated lytic cell death called pyroptosis. Mammals encode five gasdermins that can trigger pyroptosis: GSDMA, B, C, D, and E. Caspase and granzyme proteases cleave the l…

Caspase-1 activates gasdermin A in non-mammals Open

Zachary P. Billman, Stephen B. Kovacs, Bo Wei, Kidong Kang, Ousmane H. Cissé , et al. · 2024

Gasdermins oligomerize to form pores in the cell membrane, causing regulated lytic cell death called pyroptosis. Mammals encode five gasdermins that can trigger pyroptosis: GSDMA, B, C, D, and E. Caspase and granzyme proteases cleave the l…

NLRP3, NLRP6, and NLRP12 are inflammasomes with distinct expression patterns Open

Bo Wei, Zachary P. Billman, Kengo Nozaki, Helen S. Goodridge, Edward A. Miao · 2024

Inflammasomes are sensors that detect cytosolic microbial molecules or cellular damage, and in response they initiate a form of lytic regulated cell death called pyroptosis. Inflammasomes signal via homotypic protein-protein interactions w…

Chemokine expression profile of an innate granuloma Open

Megan E. Amason, Cole J. Beatty, Carissa K. Harvest, Daniel R. Saban, Edward A. Miao · 2024

Granulomas are defined by the presence of organized layers of immune cells that include macrophages. Granulomas are often characterized as a way for the immune system to contain an infection and prevent its dissemination. We recently estab…

Validation of the Intermolecular Disulfide Bond in Caspase-2 Open

Megan E. Amason, Lupeng Li, Carissa K. Harvest, Carolyn A. Lacey, Edward A. Miao · 2024

Caspases are a family of proteins involved in cell death. Although several caspase members have been well characterized, caspase-2 remains enigmatic. Caspase-2 has been implicated in several phenotypes, but there has been no consensus in t…