Edward Chow
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View article: Prospective surveillance and early intervention to prevent chronic breast cancer-related arm lymphedema—what are the barriers?
Prospective surveillance and early intervention to prevent chronic breast cancer-related arm lymphedema—what are the barriers? Open
Up to one in five early breast cancer patients develop chronic upper limb lymphedema after breast cancer treatments. This treatment complication is irreversible and can significantly impact the quality of life of breast cancer survivors. T…
View article: 297P Modified Delphi consensus on interventions for radiation dermatitis in breast cancer: A Canadian expert perspective
297P Modified Delphi consensus on interventions for radiation dermatitis in breast cancer: A Canadian expert perspective Open
Acute radiation dermatitis is a prevalent adverse effect of radiotherapy in patients with breast cancer, and there is a lack of high-quality data regarding its prevention and management, which leads to a lack of standardized care This stud…
View article: Reirradiation of metastases of the central nervous system: part 2—metastatic epidural spinal cord compression
Reirradiation of metastases of the central nervous system: part 2—metastatic epidural spinal cord compression Open
An increasing number of patients irradiated for metastatic epidural spinal cord compression (MESCC) experience an in-field recurrence and require a second course of radiotherapy. Reirradiation can be performed with conventional radiotherap…
View article: Quality of life issues faced by patients with keratinocyte cancer: A systematic review
Quality of life issues faced by patients with keratinocyte cancer: A systematic review Open
Introduction: keratinocyte carcinomas (KC), including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), represent the most prevalent malignancy worldwide with a rapidly increasing incidence. While KC and its treatmen…
View article: Addressing concerns and uncertainties surrounding the application of palliative radiotherapy in cases with a 30-day expected mortality
Addressing concerns and uncertainties surrounding the application of palliative radiotherapy in cases with a 30-day expected mortality Open
status: Published
View article: Latest clinical research in leptomeningeal disease (LMD)—a narrative review
Latest clinical research in leptomeningeal disease (LMD)—a narrative review Open
The current clinical trials in LMD offer the promise to improve the diagnosis and treatment outcomes of patients with LMD. More research is needed to overcome the potential hurdles in the current treatment and bridge the knowledge gaps as …
View article: A systematic review of the use of the then-test for evaluating health-related quality of life in cancer patients
A systematic review of the use of the then-test for evaluating health-related quality of life in cancer patients Open
Our review demonstrates that the then-test measurement tool has been commonly used for the detection of response shift. Newer measures for response shift have become more accepted; the then-test, if used, should be used with caution consid…
View article: Real world patient-reported and health care professional-perceived pain severity in outpatient fracture clinic procedures
Real world patient-reported and health care professional-perceived pain severity in outpatient fracture clinic procedures Open
Introduction Management of orthopaedic fractures involves acute intervention and follow up through to recovery. Patient-centered care needs to encompass all aspects of this treatment. Limited research is available on outpatient satisfactio…
View article: Prevalence and Prognostic Implications of PSA Flares during Radium-223 Treatment among Men with Metastatic Castration Resistant Prostate Cancer
Prevalence and Prognostic Implications of PSA Flares during Radium-223 Treatment among Men with Metastatic Castration Resistant Prostate Cancer Open
Radium-223 (Ra233) prolongs the survival of men with symptomatic bone-predominant metastatic castration-resistant prostate cancer (mCRPC). However, prostate-specific antigen (PSA) response patterns are not closely associated with Ra223 the…
View article: Novel MRI-guided focussed ultrasound stimulated microbubble radiation enhancement treatment for breast cancer
Novel MRI-guided focussed ultrasound stimulated microbubble radiation enhancement treatment for breast cancer Open
Preclinical studies have demonstrated focused ultrasound (FUS) stimulated microbubble (MB) rupture leads to the activation of acid sphingomyelinase-ceramide pathway in the endothelial cells. When radiotherapy (RT) is delivered concurrently…
View article: Appropriateness of the 30-day expected mortality metric in palliative radiation treatment: a narrative review
Appropriateness of the 30-day expected mortality metric in palliative radiation treatment: a narrative review Open
Single-fraction palliative RT should be offered to eligible patients if they are able to attend treatment and could potentially benefit from symptom palliation, irrespective of predicted life expectancy. We discourage the routine use of th…
View article: Figure S1 from Photodynamic Therapy for the Treatment of Vertebral Metastases: A Phase I Clinical Trial
Figure S1 from Photodynamic Therapy for the Treatment of Vertebral Metastases: A Phase I Clinical Trial Open
Figure S1 shows an overview of the PDT fiber set-up and placement for a kyphoplasty case.
View article: Table S1 from Photodynamic Therapy for the Treatment of Vertebral Metastases: A Phase I Clinical Trial
Table S1 from Photodynamic Therapy for the Treatment of Vertebral Metastases: A Phase I Clinical Trial Open
Table S1 highlights the inclusion/exclusion criteria for the PDT clinical trial in table format.
View article: Data from Photodynamic Therapy for the Treatment of Vertebral Metastases: A Phase I Clinical Trial
Data from Photodynamic Therapy for the Treatment of Vertebral Metastases: A Phase I Clinical Trial Open
Purpose:Vertebroplasty (VP) and balloon kyphoplasty (KP) are minimally invasive stabilization procedures for pathologic vertebral compression fractures (VCF). Concurrent administration of photodynamic therapy (PDT) as a tumor-ablative moda…
View article: Data from Photodynamic Therapy for the Treatment of Vertebral Metastases: A Phase I Clinical Trial
Data from Photodynamic Therapy for the Treatment of Vertebral Metastases: A Phase I Clinical Trial Open
Purpose:Vertebroplasty (VP) and balloon kyphoplasty (KP) are minimally invasive stabilization procedures for pathologic vertebral compression fractures (VCF). Concurrent administration of photodynamic therapy (PDT) as a tumor-ablative moda…
View article: Table S1 from Photodynamic Therapy for the Treatment of Vertebral Metastases: A Phase I Clinical Trial
Table S1 from Photodynamic Therapy for the Treatment of Vertebral Metastases: A Phase I Clinical Trial Open
Table S1 highlights the inclusion/exclusion criteria for the PDT clinical trial in table format.
View article: Figure S1 from Photodynamic Therapy for the Treatment of Vertebral Metastases: A Phase I Clinical Trial
Figure S1 from Photodynamic Therapy for the Treatment of Vertebral Metastases: A Phase I Clinical Trial Open
Figure S1 shows an overview of the PDT fiber set-up and placement for a kyphoplasty case.
View article: MASCC clinical practice guidelines for the prevention and management of acute radiation dermatitis: part 1) systematic review
MASCC clinical practice guidelines for the prevention and management of acute radiation dermatitis: part 1) systematic review Open
Acute radiation dermatitis (ARD) commonly develops in cancer patients undergoing radiotherapy and is often characterized by erythema, desquamation, and pain. A systematic review was conducted to summarize the current evidence on interventi…
View article: Novel MRI-guided Focussed Ultrasound Stimulated Microbubble Radiation Enhancement Treatment for Breast Cancer
Novel MRI-guided Focussed Ultrasound Stimulated Microbubble Radiation Enhancement Treatment for Breast Cancer Open
Background Preclinical studies have demonstrated focused ultrasound (FUS) stimulated microbubble (MB) rupture leads to the activation of acid sphingomyelinase-ceramide pathway in the endothelial cells. When radiotherapy (RT) is delivered c…
View article: Cardiovascular Events and Mortality in Patients Undergoing Adjuvant Radiotherapy for Breast Cancer: a Systematic Review
Cardiovascular Events and Mortality in Patients Undergoing Adjuvant Radiotherapy for Breast Cancer: a Systematic Review Open
Objective: We performed a systematic review to quantify the cardiovascular risk of adjuvant radiotherapy (RT) for breast cancer.Methods: A literature search was conducted using MEDLINE, Embase, and the Cochrane Central Register of Controll…
View article: Bone health in cancer: ESMO Clinical Practice Guidelines
Bone health in cancer: ESMO Clinical Practice Guidelines Open
The clinical course of advanced cancer for many patients with bone metastases can be transformed through optimum multidisciplinary management. • Bone-targeted agents significantly reduce skeletal morbidity in patients with bone metastases …