Explanipedia

Development of a paediatric asthma shared decision-making tool: intervention design and evaluation Open

Casper E. W. Gijsen, Carolien van Rossem, Regina The, Jean Muris, Marieke W. P. van Horck , et al. · 2025

Improving asthma care in children: revealing needs and bottlenecks through in-depth interviews Open

Casper E. W. Gijsen, Carolien van Rossem, Jean Muris, Marieke W. P. van Horck, Edward Dompeling · 2024

Asthma affects 7% of Dutch children and poses an increasing challenge, highlighting the need for effective paediatric asthma care. Achieving optimal asthma control is crucial given the potentially negative long-term effects of bad asthma c…

Efficacy of <span>eHealth</span> monitoring in pediatric asthma Open

Casper E. W. Gijsen, Thijs R. P. Bogers, Jean Muris, Marieke W. P. van Horck, Edward Dompeling · 2024

Immune Response and Exhaled Breath Profile Changes after Initiation of CFTR Modulator Therapy in Children with CF Open

Koen van Aerde, Gerben Ferwerda, Agnieszka Smolinska, Edward Dompeling, Jolt Roukema · 2024

Background: In recent years, cystic fibrosis transmembrane regulator (CFTR) modulating therapy has made it possible to treat the underlying pathophysiological defect in children with cystic fibrosis (CF). Response to therapy varies among p…

Less asthma control with telemedicine in children during COVID-pandemic Open

Casper E. W. Gijsen, Edward Dompeling, Evy H.C. Mulders, Marieke W. P. van Horck · 2023

To the editor, Asthma is a chronic disease and a notable cause of morbidity, affecting approximately 10% of all children worldwide 1 .The main goal of asthma treatment in children is to achieve good asthma control.The Global

FDA-approved drug screening in patient-derived organoids demonstrates potential of drug repurposing for rare cystic fibrosis genotypes Open

Eyleen de Poel, Sacha Spelier, Marne C. Hagemeijer, Peter van Mourik, S.W.F. Suen , et al. · 2023

The ADEM2 project: early pathogenic mechanisms of preschool wheeze and a randomised controlled trial assessing the gain in health and cost-effectiveness by application of the breath test for the diagnosis of asthma in wheezing preschool children Open

Sophie Kienhorst, Moniek H. D. van Aarle, Quirijn Jöbsis, Michiel Bannier, Elin T.G. Kersten , et al. · 2023

FDA-Approved Drug Screening in Patient-Derived Organoids Demonstrates Potential of Drug Repurposing for Rare Cystic Fibrosis Genotypes Open

Eyleen de Poel, Sacha Spelier, Marne C. Hagemeijer, Peter van Mourik, S.W.F. Suen , et al. · 2022

Background Preclinical cell-based assays that recapitulate human disease play an important role in drug repurposing. We previously developed a functional forskolin induced swelling (FIS) assay using patient-derived intestinal organoids (PD…

Exhaled Breath Analysis for Investigating the Use of Inhaled Corticosteroids and Corticosteroid Responsiveness in Wheezing Preschool Children Open

Michiel Bannier, Sophie Kienhorst, Quirijn Jöbsis, Kim D. G. van de Kant, Frederik‐Jan van Schooten , et al. · 2022

Exhaled breath analysis has great potential in diagnosing various respiratory and non-respiratory diseases. In this study, we investigated the influence of inhaled corticosteroids (ICS) on exhaled volatile organic compounds (VOCs) of wheez…

Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression Open

Danya Muilwijk, Eyleen de Poel, Peter van Mourik, Sylvia W.F. Suen, Annelotte M. Vonk , et al. · 2022

Rationale Cystic fibrosis (CF) is a monogenic life-shortening disease associated with highly variable individual disease progression which is difficult to predict. Here we assessed the association of forskolin-induced swelling (FIS) of pat…

665: Forskolin-induced intestinal organoid swelling predicts long-term cystic fibrosis disease progression Open

Danya Muilwijk, Eyleen de Poel, Peter van Mourik, S.W.F. Suen, Annelotte M. Vonk , et al. · 2021

The risk of community-acquired pneumonia in children using gastric acid suppressants Open

Linda J. T. M. van der Sande, Quirijn Jöbsis, Michiel Bannier, E.M.W. van de Garde, Jan J.M. Coremans , et al. · 2021

Background With the increased use of acid suppressants, significant potential complications such as community-acquired pneumonia (CAP) are becoming more apparent. Paradoxically, in spite of an increased focus on potential complications, th…

Forskolin-induced swelling of intestinal organoids predicts long-term cystic fibrosis disease progression Open

D. Muilwijk, Eyleen de Poel, Peter van Mourik, S.W.F. Suen, Annelotte M. Vonk , et al. · 2021

Patient-derived organoids hold great potential as predictive biomarker for disease expression or therapeutic response. Here, we used intestinal organoids to estimate individual cystic fibrosis transmembrane conductance regulator (CFTR) fun…

Feasibility study on exhaled-breath analysis by untargeted Selected-Ion Flow-Tube Mass Spectrometry in children with cystic fibrosis, asthma, and healthy controls: Comparison of data pretreatment and classification techniques Open

Karen Segers, Amorn Slosse, Johan Viaene, Michiel Bannier, Kim D. G. van de Kant , et al. · 2021

The Longitudinal Relationship Between Screen Time, Sleep and a Diagnosis of Attention-Deficit/Hyperactivity Disorder in Childhood Open

Birgit Levelink, Marjolein van der Vlegel, Monique Mommers, Jessica S. Gubbels, Edward Dompeling , et al. · 2020

Objective: To evaluate longitudinal associations between recreational screen time and sleep in early childhood, and attention-deficit/hyperactivity disorder (ADHD) at age 8 to 10 years. Method: Questionnaires from 2,768 mother-child pairs …

P223 Establishing the Dutch Cystic Fibrosis Trial Consortium: opportunities for better trial participation Open

S. Michel, A. Geel, N. Keijzers, N. Adriaens, M. Smink , et al. · 2020

Discrepancy between Lung Function Measurements at Home and in the Hospital in Children with Asthma and CF Open

Frederick L.G.R. Gerzon, Quirijn Jöbsis, Michiel Bannier, Björn Winkens, Edward Dompeling · 2020

The Coronavirus pandemic stresses the importance of eHealth techniques to monitor patients at home. Home monitoring of lung function in asthma and cystic fibrosis (CF) may help to detect deterioration of lung function at an early stage, bu…

Longitudinal Relationships between Asthma-Specific Quality of Life and Asthma Control in Children; The Influence of Chronic Rhinitis Open

Dillys van Vliet, Brigitte A.B. Essers, Björn Winkens, Jan Heynens, Jean Muris , et al. · 2020

Managing pediatric asthma includes optimizing both asthma control and asthma-specific quality of life (QoL). However, it is unclear to what extent asthma-specific QoL is related to asthma control or other clinical characteristics over time…

Socio-ecological determinants of lifestyle behavior of women with overweight or obesity before, during and after pregnancy: qualitative interview analysis in the Netherlands Open

Yvon E.G. Timmermans, Kim D. G. van de Kant, J.S.M. Krumeich, Luc J. I. Zimmermann, Edward Dompeling , et al. · 2020

Gut microbiota in wheezing preschool children and the association with childhood asthma Open

Michiel Bannier, Niels van Best, Liene Bervoets, Paul H. M. Savelkoul, Mathias W. Hornef , et al. · 2019

Reliable biomarkers to predict asthma in wheezing preschool children are lacking. Recently, the impact of gut microbial perturbations on the development of asthma gained widespread attention. Gut microbial dysbiosis in the first year of li…

Towards Prepared mums (TOP-mums) for a healthy start, a lifestyle intervention for women with overweight and a child wish: study protocol for a randomised controlled trial in the Netherlands Open

Yvon E.G. Timmermans, Kim D. G. van de Kant, Dorien Reijnders, Lina M P Kleijkers, Edward Dompeling , et al. · 2019

Introduction Periconception obesity is associated with a higher risk for adverse perinatal outcomes such as gestational diabetes mellitus, preeclampsia, large for gestational age, operative delivery and preterm birth. Lifestyle interventio…

Guideline use among different healthcare professionals in diagnosing attention deficit hyperactivity disorder in Dutch children; who cares? Open

Birgit Levelink, Lonneke Walraven, Edward Dompeling, Frans Feron, Dorothea M. C. B. van Zeben-van der Aa · 2019

Exhaled Breath Condensate in Childhood Asthma: A Review and Current Perspective Open

Michiel Bannier, Philippe Rosias, Quirijn Jöbsis, Edward Dompeling · 2019

Exhaled breath condensate (EBC) was introduced more than two decades ago as a novel, non-invasive tool to assess airway inflammation. This review summarizes the latest literature on the various markers in EBC to predict asthma in children.…

Publisher Correction: Early detection of pulmonary exacerbations in children with Cystic Fibrosis by electronic home monitoring of symptoms and lung function Open

Marieke van Horck, Björn Winkens, Geertjan Wesseling, Dillys van Vliet, Kim van de Kant , et al. · 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

Risk factors for lung disease progression in children with cystic fibrosis Open

Marieke van Horck, Kim van de Kant, Björn Winkens, Geertjan Wesseling, Vincent Gulmans , et al. · 2018

To identify potential risk factors for lung disease progression in children with cystic fibrosis (CF), we studied the longitudinal data of all children with CF (aged ≥5 years) registered in the Dutch CF Registry (2009–2014). Lung disease p…

Children With ADHD Symptoms: Who Can Do Without Specialized Mental Health Care? Open

Birgit Levelink, Frans Feron, Edward Dompeling, Dorothea M. C. B. van Zeben-van de Aa · 2018

Objective: A new Dutch Child and Youth Act should reduce specialized mental health care for children with symptoms of ADHD. Characteristics of children referred to a specialized ADHD clinic are explored to give direction to this intention.…

Recruiting families for an intervention study to prevent second-hand smoke exposure in children Open

Sasha Hutchinson, Constant P. van Schayck, Jean Muris, Frans Feron, Edward Dompeling · 2018

Motivational interviewing and urine cotinine feedback to stop passive smoke exposure in children predisposed to asthma: a randomised controlled trial Open

Sasha Hutchinson, Gerard van Breukelen, Constant P. van Schayck, Brigitte A.B. Essers, S. Katharine Hammond , et al. · 2017

We tested the effectiveness of a program consisting of motivational interviewing (MI) and feedback of urine cotinine to stop passive smoking (PS) in children at risk for asthma. Fifty-eight families with children 0–13 years with a high ris…

Early detection of pulmonary exacerbations in children with Cystic Fibrosis by electronic home monitoring of symptoms and lung function Open

Marieke van Horck, Björn Winkens, Geertjan Wesseling, Dillys van Vliet, Kim van de Kant , et al. · 2017

Correction: A Multifactorial Weight Reduction Programme for Children with Overweight and Asthma: A Randomized Controlled Trial Open

Maartje Willeboordse, Kim D. G. van de Kant, Frans E. S. Tan, Sandra Mulkens, Julia Schellings , et al. · 2017

[This corrects the article DOI: 10.1371/journal.pone.0157158.].

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