Edward E. Cable
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View article: Peroxisome proliferator–activated receptor delta and liver diseases
Peroxisome proliferator–activated receptor delta and liver diseases Open
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in transcriptional regulation and play an important role in many physiological and metabolic processes. Unlike PPAR-alpha and PPAR-gamma, PPAR-delta is ubiq…
View article: Single‐Nuclei RNA Sequencing Shows the Engagement of PPAR‐Delta Target Genes Primarily in Hepatocytes and Cholangiocytes by the Selective PPAR‐Delta Agonist Seladelpar
Single‐Nuclei RNA Sequencing Shows the Engagement of PPAR‐Delta Target Genes Primarily in Hepatocytes and Cholangiocytes by the Selective PPAR‐Delta Agonist Seladelpar Open
Background and Aims The selective peroxisome proliferator–activated receptor delta (PPARD) agonist seladelpar reduces liver injury and modulates bile acid metabolism in preclinical models. Seladelpar was recently approved for the secondary…
View article: Single and Multiple Doses of Seladelpar Decrease Diurnal Markers of Bile Acid Synthesis in Mice
Single and Multiple Doses of Seladelpar Decrease Diurnal Markers of Bile Acid Synthesis in Mice Open
Peroxisome proliferator–activated receptors (PPARs) modulate bile metabolism and are important therapeutic options in cholestatic diseases. This study was aimed at understanding the effects of single and multiple doses of seladelpar, a PPA…
View article: OCE-205, a Selective V1a Partial Agonist, Reduces Portal Pressure in Rat Models of Portal Hypertension
OCE-205, a Selective V1a Partial Agonist, Reduces Portal Pressure in Rat Models of Portal Hypertension Open
Procedures were approved by the Ferring Research Institute (FRI) Institutional Animal Care and Use Committee on July 13, 2011, under protocol FRI-07-0002.
View article: Selective Partial Agonism of Vasopressin 1a Receptors <i>In Vitro</i> by OCE-205
Selective Partial Agonism of Vasopressin 1a Receptors <i>In Vitro</i> by OCE-205 Open
Objective To test the selectivity and degree of functional agonism of Ocelot Bio’s dual agonist/antagonist molecule, OCE-205, at the vasopressin 1a receptor (V1aR). Methods Cells expressing human (h) or rat V1a, V1b, V2, or oxytocin recept…
View article: OCE-205 in rats and non-human primates: Pharmacokinetic and pharmacodynamic analysis
OCE-205 in rats and non-human primates: Pharmacokinetic and pharmacodynamic analysis Open
Procedures were approved by the Ferring Research Institute (FRI) Institutional Animal Care and Use Committee (IACUC) on November 27, 2006 under protocol FRI 06-011, and by the Sinclair Research Center IACUC under protocol S11177.