Edward G. Stopa
YOU?
Author Swipe
View article: Meningeal B Cell Clusters Correlate with Submeningeal Pathology in a Natural Model of Multiple Sclerosis
Meningeal B Cell Clusters Correlate with Submeningeal Pathology in a Natural Model of Multiple Sclerosis Open
Multiple sclerosis (MS) is an idiopathic demyelinating disease in which meningeal inflammation correlates with accelerated disease progression. The study of meningeal inflammation in MS has been limited because of constrained access to MS …
View article: Ontogeny of inter‐alpha inhibitor protein (IAIP) expression in human brain
Ontogeny of inter‐alpha inhibitor protein (IAIP) expression in human brain Open
Inter‐alpha inhibitor proteins (IAIPs) are naturally occurring immunomodulatory molecules found in most tissues. We have reported ontogenic changes in the expression of IAIPs in brain during development in sheep and abundant expression of …
View article: Eosinophilic Polymyositis: A Rare Cause of Atraumatic Compartment Syndrome of the Forearm
Eosinophilic Polymyositis: A Rare Cause of Atraumatic Compartment Syndrome of the Forearm Open
View article: Evaluation of the Structure of Myodural Bridges in an Equine Model of Ehlers-Danlos Syndromes
Evaluation of the Structure of Myodural Bridges in an Equine Model of Ehlers-Danlos Syndromes Open
View article: Neuroprotective effects of inter-alpha inhibitor proteins after hypoxic-ischemic brain injury in neonatal rats
Neuroprotective effects of inter-alpha inhibitor proteins after hypoxic-ischemic brain injury in neonatal rats Open
View article: Choroid plexus genes for CSF production and brain homeostasis are altered in Alzheimer’s disease
Choroid plexus genes for CSF production and brain homeostasis are altered in Alzheimer’s disease Open
Because the altered expression of numerous transcripts in AD-CP help explain decreased CSF production in AD, these findings represent a first step towards identifying novel therapeutic targets in AD.
View article: Gastrointestinal iron excretion and reversal of iron excess in a mouse model of inherited iron excess
Gastrointestinal iron excretion and reversal of iron excess in a mouse model of inherited iron excess Open
The current paradigm in the field of mammalian iron biology states that body iron levels are determined by dietary iron absorption, not by iron excretion. Iron absorption is a highly regulated process influenced by iron levels and other fa…
View article: Blood-Cerebrospinal Fluid Barrier Gradients in Mild Cognitive Impairment and Alzheimer's Disease: Relationship to Inflammatory Cytokines and Chemokines
Blood-Cerebrospinal Fluid Barrier Gradients in Mild Cognitive Impairment and Alzheimer's Disease: Relationship to Inflammatory Cytokines and Chemokines Open
Background: The pathophysiology underlying altered blood-cerebrospinal fluid barrier (BCSFB) function in Alzheimer's disease (AD) is unknown but may relate to endothelial cell activation and cytokine mediated inflammation. Method…
View article: Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis
Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis Open
View article: Oxytocin‐ and arginine vasopressin‐containing fibers in the cortex of humans, chimpanzees, and rhesus macaques
Oxytocin‐ and arginine vasopressin‐containing fibers in the cortex of humans, chimpanzees, and rhesus macaques Open
Oxytocin (OT) and arginine‐vasopressin (AVP) are involved in the regulation of complex social behaviors across a wide range of taxa. Despite this, little is known about the neuroanatomy of the OT and AVP systems in most non‐human primates,…
View article: Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP+PS1 double transgenic rat model of Alzheimer’s disease
Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP+PS1 double transgenic rat model of Alzheimer’s disease Open
Transgenic rat models of Alzheimer's disease were used to examine differences in memory and brain histology. Double transgenic female rats (APP+PS1) over-expressing human amyloid precursor protein (APP) and presenilin 1 (PS1) and single tr…
View article: Counteracting the effects of <scp>TNF</scp> receptor‐1 has therapeutic potential in Alzheimer's disease
Counteracting the effects of <span>TNF</span> receptor‐1 has therapeutic potential in Alzheimer's disease Open
View article: Disrupted Blood-CSF Barrier to Urea and Creatinine in Mild Cognitive Impairment and Alzheimer's Disease
Disrupted Blood-CSF Barrier to Urea and Creatinine in Mild Cognitive Impairment and Alzheimer's Disease Open
Objective: In this pilot study hypothesizing that blood-CSF barrier (BCSFB) function is altered in mild cognitive impairment (MCI), we evaluated small-sized biomarker distribution between serum (SER) and cerebrospinal fluid (CSF). For both…
View article: MOESM4 of Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis
MOESM4 of Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis Open
Additional file 4: Table S4. The top 10 most upregulated and top 10 most downregulated genes in the AD vs. Ctrl comparison, with p
View article: MOESM3 of Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis
MOESM3 of Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis Open
Additional file 3: Table S3. Geneset Annotations: Worksheets contain pathways enriched among genes upregulated in AD vs. Ctrl (S3a); downregulated in AD vs. Ctrl (S3b); upregulated in AD but not in HuD + FTD vs. Ctrl (S3c); and upregulated…
View article: MOESM1 of Choroid plexus genes for CSF production and brain homeostasis are altered in Alzheimerâ s disease
MOESM1 of Choroid plexus genes for CSF production and brain homeostasis are altered in Alzheimerâ s disease Open
Additional file 1. Gene expression values.
View article: MOESM2 of Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis
MOESM2 of Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis Open
Additional file 2: Table S2. T-test results for choroid plexus RNA from 6 control, 7 Alzheimer’s disease, 4 FTD and 3HUD subjects: T-test p-values and expression differences (Log10 Disease/Ctrl) for each disease type are provided for all 5…
View article: MOESM1 of Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis
MOESM1 of Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis Open
Additional file 1: Table S1. Sample Annotations and Patient Demographics: ‘QC passed’ indicates samples passing both RNA and Affymetrix quality control, and used for analysis. APOE; genotype data consist of combinations of the ε2, ε3 and ε…
View article: [P2–089]: BLOOD‐BRAIN BARRIER GRADIENTS IN MILD COGNITIVE IMPAIRMENT AND ALZHEIMER's DISEASE: RELATIONSHIP TO INFLAMMATORY CYTOKINES AND CHEMOKINES
[P2–089]: BLOOD‐BRAIN BARRIER GRADIENTS IN MILD COGNITIVE IMPAIRMENT AND ALZHEIMER's DISEASE: RELATIONSHIP TO INFLAMMATORY CYTOKINES AND CHEMOKINES Open
We have previously shown perturbed blood-brain barrier (BBB) function in mild cognitive impairment (MCI) and Alzheimer's disease (AD), evidenced by increased permeability (urea and albumin) and decreased active transport (creatinine). The …
View article: Collision Metastasis of Chronic Lymphocytic Leukemia and Glioblastoma: A Case Report
Collision Metastasis of Chronic Lymphocytic Leukemia and Glioblastoma: A Case Report Open
Collision tumors or metastasis from an extracranial tumor to a primary brain neoplasm are rare but do occur. The majority involve metastases to meningiomas. This case presents the second documented collision of a systemic chronic lymphocyt…
View article: HMGB1 Translocation After Ischemia in the Ovine Fetal Brain
HMGB1 Translocation After Ischemia in the Ovine Fetal Brain Open
Inflammation contributes to the evolution of hypoxic-ischemic (HI) brain injury. High-mobility group box-1 (HMGB1) is a nuclear protein that is translocated from the nucleus and released after ischemia in adult rodents and thereby initiate…
View article: Expression and localization of Inter-alpha Inhibitors in rodent brain
Expression and localization of Inter-alpha Inhibitors in rodent brain Open
View article: The Orphan C2orf40 Gene is a Neuroimmune Factor in Alzheimer's Disease.
The Orphan C2orf40 Gene is a Neuroimmune Factor in Alzheimer's Disease. Open
Expression of the orphan C2orf40 gene is associated with the aggregation of the neurofibrillary tangle-protein tau in transgenic mice, tumor suppression, the induction of senescence in CNS, and the activation of microglia and peripheral mo…
View article: Mary Ambler, MD 1932–2015
Mary Ambler, MD 1932–2015 Open
of
View article: De novo adamantinomatous craniopharyngioma presenting anew in an elderly patient with previous normal CT and MRI studies: A case report and implications on pathogenesis
De novo adamantinomatous craniopharyngioma presenting anew in an elderly patient with previous normal CT and MRI studies: A case report and implications on pathogenesis Open
View article: Human Polyomavirus Receptor Distribution in Brain Parenchyma Contrasts with Receptor Distribution in Kidney and Choroid Plexus
Human Polyomavirus Receptor Distribution in Brain Parenchyma Contrasts with Receptor Distribution in Kidney and Choroid Plexus Open
View article: Kaolin-induced chronic hydrocephalus accelerates amyloid deposition and vascular disease in transgenic rats expressing high levels of human APP
Kaolin-induced chronic hydrocephalus accelerates amyloid deposition and vascular disease in transgenic rats expressing high levels of human APP Open