Edward H. Nieh
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View article: Osmolarity Controls Oscillatory Calcium Signaling to Reduce Autonomous Aldosterone Production in Zona Glomerulosa Cells
Osmolarity Controls Oscillatory Calcium Signaling to Reduce Autonomous Aldosterone Production in Zona Glomerulosa Cells Open
Primary aldosteronism (PA) is characterized by autonomous aldosterone (Aldo) production, resulting in blood volume/electrolyte imbalance and hypertension. Intracellular calcium (Ca2+) is the principal signal driving Aldo synthesis in adren…
View article: TWINKLE: An open-source two-photon microscope for teaching and research
TWINKLE: An open-source two-photon microscope for teaching and research Open
Many laboratories use two-photon microscopy through commercial suppliers, or homemade designs of considerable complexity. The integrated nature of these systems complicates customization, troubleshooting, and training on the principles of …
View article: Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking
Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking Open
View article: TWINKLE: An open-source two-photon microscope for teaching and research
TWINKLE: An open-source two-photon microscope for teaching and research Open
Many laboratories use two-photon microscopy through commercial suppliers, or homemade designs of considerable complexity. The integrated nature of these systems complicates customization, troubleshooting, and training on the principles of …
View article: Neural circuit models for evidence accumulation through choice-selective sequences
Neural circuit models for evidence accumulation through choice-selective sequences Open
Decision making is traditionally thought to be mediated by neurons that accumulate evidence through persistent activity. However, recent decision-making experiments in rodents have observed neurons across the brain that fire sequentially, …
View article: Thalamus sends information about arousal but not valence to the amygdala
Thalamus sends information about arousal but not valence to the amygdala Open
Rationale The basolateral amygdala (BLA) and medial geniculate nucleus of the thalamus (MGN) have both been shown to be necessary for the formation of associative learning. While the role that the BLA plays in this process has long been em…
View article: Thalamus sends information about arousal but not valence to the amygdala
Thalamus sends information about arousal but not valence to the amygdala Open
Rationale The basolateral amygdala (BLA) and medial geniculate nucleus of the thalamus (MGN) have both been shown to be necessary for the formation of associative learning. While the role that the BLA plays in this process has long been em…
View article: Detecting and correcting false transients in calcium imaging
Detecting and correcting false transients in calcium imaging Open
View article: Geometry of abstract learned knowledge in the hippocampus
Geometry of abstract learned knowledge in the hippocampus Open
View article: Detecting and Correcting False Transients in Calcium Imaging
Detecting and Correcting False Transients in Calcium Imaging Open
Population recordings of calcium activity are a major source of insight into neural function. Large dataset sizes often require automated methods, but automation can introduce errors that are difficult to detect. Here we show that automati…
View article: Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning
Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning Open
View article: Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment
Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment Open
Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial pref…
View article: Homeostasis Meets Motivation in the Battle to Control Food Intake
Homeostasis Meets Motivation in the Battle to Control Food Intake Open
Signals of energy homeostasis interact closely with neural circuits of motivation to control food intake. An emerging hypothesis is that the transition to maladaptive feeding behavior seen in eating disorders or obesity may arise from dysr…
View article: Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation
Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation Open
View article: Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation
Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation Open
The motivation to seek social contact may arise from either positive or negative emotional states, as social interaction can be rewarding and social isolation can be aversive. While ventral tegmental area (VTA) dopamine (DA) neurons may me…
View article: Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation
Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation Open
View article: Lateral hypothalamic control of motivated behaviors through the midbrain dopamine system
Lateral hypothalamic control of motivated behaviors through the midbrain dopamine system Open
Thesis: Ph. D. in Neuroscience, Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, 2016.
View article: Decoding Neural Circuits that Control Compulsive Sucrose Seeking
Decoding Neural Circuits that Control Compulsive Sucrose Seeking Open
View article: Decoding Neural Circuits that Control Compulsive Sucrose Seeking
Decoding Neural Circuits that Control Compulsive Sucrose Seeking Open