Edward Yi Chang
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View article: Inverse-Free Wilson Loops for Transformers: A Practical Diagnostic for Invariance and Order Sensitivity
Inverse-Free Wilson Loops for Transformers: A Practical Diagnostic for Invariance and Order Sensitivity Open
Large language models can change answers under harmless edits that matter in practice: RAG outputs flip when passages are reordered, fine-tuning erodes invariances learned at pretraining, debate or chain-of-thought prompts take path-depend…
View article: The Unified Cognitive Consciousness Theory for Language Models: Anchoring Semantics, Thresholds of Activation, and Emergent Reasoning
The Unified Cognitive Consciousness Theory for Language Models: Anchoring Semantics, Thresholds of Activation, and Emergent Reasoning Open
We propose semantic anchoring, a unified account of how large language models turn pretrained capacity into goal-directed behavior: external structure (in-context examples, retrieval, or light tuning) binds the model's latent patterns to d…
View article: Using efficient bimetallic FeCo-ZIFs catalyst for Ciprofloxacin degradation in the presence of potassium peroxydisulfate
Using efficient bimetallic FeCo-ZIFs catalyst for Ciprofloxacin degradation in the presence of potassium peroxydisulfate Open
Solvothermal synthesis was used for the successful manufacture FeCo-ZIFs bimetallic materials. The materials' properties were determined using a variety of techniques, including Fourier-transform infrared spectroscopy (FT-IR), energy dispe…
View article: Overture: an open-source genomics data platform
Overture: an open-source genomics data platform Open
Background Next-generation sequencing has created many new technological challenges in organizing and distributing genomics datasets, which now can routinely reach petabyte scales. Coupled with data-hungry artificial intelligence and machi…
View article: IL-1 IDHWT GLIOBLASTOMA LONGITUDINAL MOLECULAR EVOLUTION
IL-1 IDHWT GLIOBLASTOMA LONGITUDINAL MOLECULAR EVOLUTION Open
We performed comprehensive histopathologic, genomic, and epigenomic evaluation of paired initial and recurrent glioblastoma specimens from 106 patients to investigate the molecular evolution and cellular phenotypes underlying differential …
View article: Supplementary Table S7 from Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline <i>POLE</i> Deficiency Treated with Checkpoint Blockade Immunotherapy
Supplementary Table S7 from Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline <i>POLE</i> Deficiency Treated with Checkpoint Blockade Immunotherapy Open
Predicted neoantigens generated as described above. This table contains all peptides with predicted ic50 less than 500 and fold-change greater than 1. The list is provided before filtering for expression or presence in the founding clone.
View article: Data from Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline <i>POLE</i> Deficiency Treated with Checkpoint Blockade Immunotherapy
Data from Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline <i>POLE</i> Deficiency Treated with Checkpoint Blockade Immunotherapy Open
We present the case of a patient with a left frontal glioblastoma with primitive neuroectodermal tumor features and hypermutated genotype in the setting of a POLE germline alteration. During standard-of-care chemoradiation, the patient dev…
View article: Supplementary Table S3 from Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline <i>POLE</i> Deficiency Treated with Checkpoint Blockade Immunotherapy
Supplementary Table S3 from Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline <i>POLE</i> Deficiency Treated with Checkpoint Blockade Immunotherapy Open
Gene Fusions identified with INTEGRATE.
View article: Supplementary Table S1 from Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline <i>POLE</i> Deficiency Treated with Checkpoint Blockade Immunotherapy
Supplementary Table S1 from Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline <i>POLE</i> Deficiency Treated with Checkpoint Blockade Immunotherapy Open
Somatic SNVs and Indels with transcript annotation, population frequencies, and readcounts appended.
View article: Supplementary Table S2 from Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline <i>POLE</i> Deficiency Treated with Checkpoint Blockade Immunotherapy
Supplementary Table S2 from Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline <i>POLE</i> Deficiency Treated with Checkpoint Blockade Immunotherapy Open
Segmented somatic copy number calls.
View article: Supplementary Table S6 from Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline <i>POLE</i> Deficiency Treated with Checkpoint Blockade Immunotherapy
Supplementary Table S6 from Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline <i>POLE</i> Deficiency Treated with Checkpoint Blockade Immunotherapy Open
Clonal clustering assignments generated from sciClone.
View article: Data from Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline <i>POLE</i> Deficiency Treated with Checkpoint Blockade Immunotherapy
Data from Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline <i>POLE</i> Deficiency Treated with Checkpoint Blockade Immunotherapy Open
We present the case of a patient with a left frontal glioblastoma with primitive neuroectodermal tumor features and hypermutated genotype in the setting of a POLE germline alteration. During standard-of-care chemoradiation, the patient dev…
View article: Design and Automation of a Zero-Energy Model House (ZEH)
Design and Automation of a Zero-Energy Model House (ZEH) Open
DESIGN AND AUTOMATION OF A ZERO ENERGY HOUSE (ZEH) MODELDue to the rising energy prices, green-house effects, and environmental concerns, there has beena lot of emphasis on using alternative, renewable energy sources. This paper is concern…
View article: Study of the interface stability of the metal (Mo, Ni, Pd)/HfO2/AlN/InGaAs MOS devices
Study of the interface stability of the metal (Mo, Ni, Pd)/HfO2/AlN/InGaAs MOS devices Open
The degeneration of the metal/HfO2 interfaces for Mo, Ni, and Pd gate metals was studied in this paper. An unstable PdOx interfacial layer formed at the Pd/HfO2 interface, inducing the oxygen segregation for the Pd/HfO2/InGaAs metal oxide …
View article: Growth of ultrathin GaSb layer on GaAs using metal–organic chemical vapor deposition with Sb interfacial treatment
Growth of ultrathin GaSb layer on GaAs using metal–organic chemical vapor deposition with Sb interfacial treatment Open
GaSb epitaxial layers were directly grown on GaAs substrates by metal–organic chemical vapor deposition involving Sb interfacial treatment with optimized growth temperature and V/III ratio. The interfacial treatment effectively reduces the…