Edward S. Henderson
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View article: Chemotherapy of Advanced Hodgkin's Disease with MOPP, ABVD, or MOPP Alternating with ABVD
Chemotherapy of Advanced Hodgkin's Disease with MOPP, ABVD, or MOPP Alternating with ABVD Open
In this trial, ABVD therapy for 6 to 8 months was as effective as 12 months of MOPP alternating with ABVD, and both were superior to MOPP alone in the treatment of advanced Hodgkin's disease. ABVD was less myelotoxic than MOPP or ABVD alte…
View article: Comparison of psychosocial adaptation and sexual function of survivors of advanced hodgkin disease treated by MOPP, ABVD, or MOPP alternating with ABVD
Comparison of psychosocial adaptation and sexual function of survivors of advanced hodgkin disease treated by MOPP, ABVD, or MOPP alternating with ABVD Open
No significant long-term advantage in psychosocial adaptation or psychosexual function was found for survivors of Hodgkin disease treated by the less gonadally toxic ABVD regimen 1 to 5 years after completion of treatment.
View article: Hodgkin disease survivors at increased risk for problems in psychosocial adaptation
Hodgkin disease survivors at increased risk for problems in psychosocial adaptation Open
These findings suggest that including a routine assessment of these factors would help to target survivors in need of additional evaluation and treatment.
View article: A randomized comparison of methotrexate dose and the addition of bleomycin to chop therapy for diffuse large cell lymphoma and other non-Hodgkin's lymphomas cancer and leukemia group B study 7851
A randomized comparison of methotrexate dose and the addition of bleomycin to chop therapy for diffuse large cell lymphoma and other non-Hodgkin's lymphomas cancer and leukemia group B study 7851 Open
In 1978, Cancer and Leukemia Group B initiated a randomized study to determine the usefulness of the addition of bleomycin and/or high-dose methotrexate to standard therapy for the treatment of certain adult non-Hodgkin's lymphomas. Betwee…
View article: An autopsy study of 1206 acute and chronic leukemias (1958 to 1982)
An autopsy study of 1206 acute and chronic leukemias (1958 to 1982) Open
Autopsy data on 1,206 children and adult patients with acute myelocytic leukemia (AML) (585), chronic granulocytic leukemia (CGL) (204), acute lymphocytic leukemia (ALL) (308), and chronic lymphocytic leukemia (CLL) (109) obtained from 195…
View article: Cyclophosphamide, vincristine, adriamycin, and prednisone (CHOP) with and without intermediate dose methotrexate for the treatment of non-Hodgkin's lymphomas of diffuse histology
Cyclophosphamide, vincristine, adriamycin, and prednisone (CHOP) with and without intermediate dose methotrexate for the treatment of non-Hodgkin's lymphomas of diffuse histology Open
Seventy three patients with disseminated diffuse non-Hodgkin's lymphomas were treated with combinations of cyclophosphamide, vincristine sulfate, prednisone, and doxorubicin with and without 2 weekly doses of oral methotrexate in "intermed…
View article: Comparison of oral melphalan, CCNU, and BCNU with and without vincristine and prednisone in the treatment of multiple myeloma. Cancer and leukemia group B experience
Comparison of oral melphalan, CCNU, and BCNU with and without vincristine and prednisone in the treatment of multiple myeloma. Cancer and leukemia group B experience Open
A total of 361 evaluable patients with previously untreated multiple myeloma were randomized to receive oral melphalan (0.15 mg/kg/day for seven days, followed by 0.05 mg/kg/day after recovery from the nadir of the leukocytes), BCNU (150 m…
View article: Granulocyte transfusions in children using filter-collected cells
Granulocyte transfusions in children using filter-collected cells Open
Twenty-three children with various stages and morphologic types of leukemia were treated with multiple granulocyte transfusions obtained by filtration leukapheresis when neutropenia-associated infection appeared unresponsive to antibiotics…
View article: Multiple myeloma, acute leukemia, and Hodgkin's disease—Occurrence in three of four family members
Multiple myeloma, acute leukemia, and Hodgkin's disease—Occurrence in three of four family members Open
Among a family of four persons, three members each had a separate malignant disease during a 3-year period. The mother and father concurrently had multiple myeloma and Hodgkin's disease, respectively, and less than 3 years later, their onl…
View article: Long-term second remissions in acute lymphatic leukemia
Long-term second remissions in acute lymphatic leukemia Open
Long-term second remissions were seen in 5/66 patients with all. Relapse was extramedullary in 2/5. Persistent, progressive marrow lymphocytosis preceded relapse in 4/5 patients and persistent marrow eosinophilia in 1/5. All 5 patients had…
View article: Cytosine arabinoside and 6-thioguanine in refractory acute lymphocytic leukemia
Cytosine arabinoside and 6-thioguanine in refractory acute lymphocytic leukemia Open
Combination therapy with cytosine arabinoside and 6-thioguanine has been found to be effective for remission induction in acute myelogenous leukemia (AML). The present study was undertaken to determine the efficacy of this combination in l…
View article: 67GA scintigraphy in acute leukemia
67GA scintigraphy in acute leukemia Open
In order to study the use of 67Ga scintigraphy in systemic malignancies, 43 whole body rectilinear scans were performed on 30 patients with acute leukemia. Results of scintigraphy were correlated with bone marrow status and evidence of inf…
View article: Cardiac ultrastructural changes induced by daunorubicin therapy
Cardiac ultrastructural changes induced by daunorubicin therapy Open
To elucidate the mechanisms of the cardiotoxicity induced by daunorubicin (DNR), histologic and ultrastructural studies were made of the hearts of six patients with acute leukemias. Three of these patients had received relatively high tota…
View article: A prospective study of anti-candida interfering factor in leukemic patients
A prospective study of anti-candida interfering factor in leukemic patients Open
To determine if interfering activity is a result of, rather than a cause of, candidiasis, serial serum samples from 15 patients with acute leukemia were studied for anti-candida agglutinating and precipitating antibodies and for anti-candi…
View article: Hypofibrinogenemia and coagulation factor deficiencies with L-asparaginase treatment
Hypofibrinogenemia and coagulation factor deficiencies with L-asparaginase treatment Open
Thirteen patients with acute leukemia were treated with L-asparaginase. Abnormalities of blood coagulation and fibrinolysis developed in all 13 patients. Decreased levels of fibrinogen, Factors V, VII-X, VIII, and IX with decreased plasmin…
View article: Effects of Bacterial Endotoxin on the Fibrinolytic Activity of Normal Human Leukocytes
Effects of Bacterial Endotoxin on the Fibrinolytic Activity of Normal Human Leukocytes Open
Two modifications of Todd’s histochemical fibrin slide technique were used to study the effect of bacterial endotoxin on the plasminogen activator activity of intact normal human leukocytes in vitro. Leukocyte suspensions were obtained fro…
View article: Transplantation of HL-A Identical Allogeneic Bone Marrow to a Patient With Acute Lymphocytic Leukemia
Transplantation of HL-A Identical Allogeneic Bone Marrow to a Patient With Acute Lymphocytic Leukemia Open
An 8-year-old boy with acute lymphocytic leukemia, no longer responsive to conventional chemotherapy after 2 years, was successfully grafted with bone marrow from his HL-A genotypically identical 10-year-old sister. Prior to transplantatio…
View article: Gastrointestinal “sterilization” in the treatment of patients with acute leukemia
Gastrointestinal “sterilization” in the treatment of patients with acute leukemia Open
In preliminary studies, a combination of gentamicin, vancomycin, and nystatin i n conjunction with either sterile or reduced-bacterial diets consistently resulted i n bacterially "sterile" stools and an apparent reduction of infection in g…
View article: Acquired coagulation factor deficiencies in leukemia
Acquired coagulation factor deficiencies in leukemia Open
Isolated Factor V and X deficiencies were associated with acute leukemia in 2 patients. Both patients manifested a hemorrhagic diathesis. in the patient with Factor V deficiency, the level of Factor V was related to the activity of his leu…
View article: Brief Report: Bone Marrow Lymphocytosis in Acute Leukemia: A Second Look
Brief Report: Bone Marrow Lymphocytosis in Acute Leukemia: A Second Look Open
A review of 54 patients with acute leukemia in remission confirms the impression that bone marrow lymphocytosis (BML) of 20 per cent or more is not a manifestation of incomplete remission, but may be an indicator of good prognosis. This co…
View article: Leukapheresis* by Continuous Flow Centrifugation (CFC) in Patients with Chronic Myelocytic Leukemia (CML)
Leukapheresis* by Continuous Flow Centrifugation (CFC) in Patients with Chronic Myelocytic Leukemia (CML) Open
A closed continuous flow centrifuge (NCI-IBM Blood Cell Separator) was utilized to collect large quantities of leukocytes from donors with chronic myelocytic leukemia. Ninety-eight separate centrifugations of one to six hours duration were…
View article: The Significance of Bone Marrow Lymphocytosis of Acute Leukemia Patients in Remission
The Significance of Bone Marrow Lymphocytosis of Acute Leukemia Patients in Remission Open
Bone marrow lymphocytosis (BML) 20 per cent or greater occurring during remission of acute leukemia has been looked upon in the past as an unfavorable sign that may presage early subsequent relapse. Seventy-four patients with acute lymphoc…