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Data from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open

Li‐Ting Wang, Shyh‐Shin Chiou, Chee‐Yin Chai, Edward Hsi, Kazunari K. Yokoyama , et al. · 2023

The intestine-specific homeobox transcription factor intestine-specific homeobox (ISX) is an IL6-inducible proto-oncogene implicated in the development of hepatocellular carcinoma, but its mechanistic contributions to this process are unde…

Figure S5 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open

Liting Wang, Shyh‐Shin Chiou, Chee‐Yin Chai, Edward Hsi, Kazunari K. Yokoyama , et al. · 2023

Figure S5, A, Western blots analysis of IDOs, AHR, PD-L1 and CD86 protein expression in various hepatoma cells. CNL: Chang normal liver cells. B, The Kaplan-Meier survival curve analysis between HCC patients with low and high expression of…

Figure S4 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open

Liting Wang, Shyh‐Shin Chiou, Chee‐Yin Chai, Edward Hsi, Kazunari K. Yokoyama , et al. · 2023

Figure S4, A to I, The ISX mRNA expression showed a strong correlation with the mRNA expression of well-known immunosuppressive genes, including IDO1 (A), TDO2 (C), KYNU (D), AHR (E), CD80 (F), CD86 (G), PD-L1 (H) and RB (I) in HCC tumors.…

Supplementary Figure Legends from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open

Liting Wang, Shyh‐Shin Chiou, Chee‐Yin Chai, Edward Hsi, Kazunari K. Yokoyama , et al. · 2023

Supplementary Information

Figure S3 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open

Liting Wang, Shyh‐Shin Chiou, Chee‐Yin Chai, Edward Hsi, Kazunari K. Yokoyama , et al. · 2023

Figure S3, A, Western blotting analysis of ISX, IDO1, TDO2, KYNU, and CYP1B1proteins in hepatocytes of AhR-null mice with treated proinflammatory cytokine IL-6 (10 ng/ml) B, The levels of kynurenine in hepatocytes of AHR+/+, AHR+/â^'and AH…

Figure S2 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open

Liting Wang, Shyh‐Shin Chiou, Chee‐Yin Chai, Edward Hsi, Kazunari K. Yokoyama , et al. · 2023

Figure S2, AHR signals positively activated ISX expression in hepatoma cells. A, Relative mRNA expression levels of CYP1B1 and ISX in Hep 3B and SK-Hep1 cells with AHR overexpression as detected by semi-quantitative RT-PCR. Data are presen…

Data from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open

Liting Wang, Shyh‐Shin Chiou, Chee‐Yin Chai, Edward Hsi, Kazunari K. Yokoyama , et al. · 2023

The intestine-specific homeobox transcription factor intestine-specific homeobox (ISX) is an IL6-inducible proto-oncogene implicated in the development of hepatocellular carcinoma, but its mechanistic contributions to this process are unde…

Figure S4 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open

Liting Wang, Shyh‐Shin Chiou, Chee‐Yin Chai, Edward Hsi, Kazunari K. Yokoyama , et al. · 2023

Figure S4, A to I, The ISX mRNA expression showed a strong correlation with the mRNA expression of well-known immunosuppressive genes, including IDO1 (A), TDO2 (C), KYNU (D), AHR (E), CD80 (F), CD86 (G), PD-L1 (H) and RB (I) in HCC tumors.…

Figure S1 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open

Liting Wang, Shyh‐Shin Chiou, Chee‐Yin Chai, Edward Hsi, Kazunari K. Yokoyama , et al. · 2023

Figure S1. ISX activated transcription of IDOs, AHR, CD86, and PD-L1 in hepatoma cells by binding to the promoter region. a, p < 0.001. A, ISX transcriptionally activated luciferase activity driven by IDO1, TDO2 B, PD-L1 and CD86 C, and AH…

Figure S5 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open

Liting Wang, Shyh‐Shin Chiou, Chee‐Yin Chai, Edward Hsi, Kazunari K. Yokoyama , et al. · 2023

Figure S5, A, Western blots analysis of IDOs, AHR, PD-L1 and CD86 protein expression in various hepatoma cells. CNL: Chang normal liver cells. B, The Kaplan-Meier survival curve analysis between HCC patients with low and high expression of…

Figure S3 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open

Liting Wang, Shyh‐Shin Chiou, Chee‐Yin Chai, Edward Hsi, Kazunari K. Yokoyama , et al. · 2023

Figure S3, A, Western blotting analysis of ISX, IDO1, TDO2, KYNU, and CYP1B1proteins in hepatocytes of AhR-null mice with treated proinflammatory cytokine IL-6 (10 ng/ml) B, The levels of kynurenine in hepatocytes of AHR+/+, AHR+/â^'and AH…

Figure S1 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open

Liting Wang, Shyh‐Shin Chiou, Chee‐Yin Chai, Edward Hsi, Kazunari K. Yokoyama , et al. · 2023

Figure S1. ISX activated transcription of IDOs, AHR, CD86, and PD-L1 in hepatoma cells by binding to the promoter region. a, p < 0.001. A, ISX transcriptionally activated luciferase activity driven by IDO1, TDO2 B, PD-L1 and CD86 C, and AH…

Figure S2 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open

Liting Wang, Shyh‐Shin Chiou, Chee‐Yin Chai, Edward Hsi, Kazunari K. Yokoyama , et al. · 2023

Figure S2, AHR signals positively activated ISX expression in hepatoma cells. A, Relative mRNA expression levels of CYP1B1 and ISX in Hep 3B and SK-Hep1 cells with AHR overexpression as detected by semi-quantitative RT-PCR. Data are presen…

Supplementary Figure Legends from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open

Liting Wang, Shyh‐Shin Chiou, Chee‐Yin Chai, Edward Hsi, Kazunari K. Yokoyama , et al. · 2023

Supplementary Information

miR-328-3p Affects Axial Length Via Multiple Routes and Anti-miR-328-3p Possesses a Potential to Control Myopia Progression Open

Chung-Ling Liang, Ku‐Chung Chen, Edward Hsi, Jui‐Yu Lin, Chien‐Yuan Chen , et al. · 2022

Micro (mi)R-328-3p affects myopia development via multiple routes. anti-miR-328-3p possesses a potential as a novel therapy for myopia control.

The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with sudden sensorineural hearing loss in a Taiwanese population: A case control study Open

Chen‐Yu Chien, Shu‐Yu Tai, Kuan-Hui Li, Hualing Yang, Leong‐Perng Chan , et al. · 2021

Background Sudden sensorineural hearing loss (SSNHL) is a disease with an unknown etiology; damage to the auditory nerve from inflammation due to viral infection or vascular incidents has been implicated. According to several studies, cyto…

Genome-wide DNA hypermethylation and homocysteine increase a risk for myopia Open

Edward Hsi, Yung‐Song Wang, Chia‐Wei Huang, Ming‐Lung Yu, Suh‐Hang Hank Juo , et al. · 2019

LINE-1 hypermethylation may be associated with high myopia in human and mice. Homocysteine and methionine are accumulated in myopic eyes, which may provide excess methyl group for genome-wide methylation.

Correction: Aryl hydrocarbon receptor regulates histone deacetylase 8 expression to repress tumor suppressive activity in hepatocellular carcinoma Open

Liting Wang, Shyh‐Shin Chiou, Chee‐Yin Chai, Edward Hsi, Shen‐Nien Wang , et al. · 2018

[This corrects the article DOI: 10.18632/oncotarget.9841.].

Correction: Aryl hydrocarbon receptor regulates histone deacetylase 8 expression to repress tumor suppressive activity in hepatocellular carcinoma (Oncotarget (2017) 8 (7489-7501) DOI: 10.18632/oncotarget.9841) Open

Li Ting Wang, Shyh Shin Chiou, Chee‐Yin Chai, Edward Hsi, Shen Nien Wang , et al. · 2018

Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression Open

Li‐Ting Wang, Shyh-Shin Chiou, Chee‐Yin Chai, Edward Hsi, Kazunari K. Yokoyama , et al. · 2017

The intestine-specific homeobox transcription factor intestine-specific homeobox (ISX) is an IL6-inducible proto-oncogene implicated in the development of hepatocellular carcinoma, but its mechanistic contributions to this process are unde…

Let-7g suppresses both canonical and non-canonical NF-κB pathways in macrophages leading to anti-atherosclerosis Open

Yung‐Song Wang, Edward Hsi, Hsin‐Yun Cheng, Shih‐Hsien Hsu, Yi‐Chu Liao , et al. · 2017

Transformation of macrophages to foam cells contributes to atherosclerosis. Here, we report that let-7g reduces macrophage transformation and alleviates foam cell apoptosis by suppressing both canonical and non-canonical NF-κB pathways. In…

Transcription factor SPZ1 promotes TWIST-mediated epithelial–mesenchymal transition and oncogenesis in human liver cancer Open

Li‐Ting Wang, S-S Chiou, Chee‐Yin Chai, Edward Hsi, C-M Chiang , et al. · 2017

Identification of IGF-1-enhanced cytokine expressions targeted by miR-181d in glioblastomas via an integrative miRNA/mRNA regulatory network analysis Open

Kuo-Hao Ho, Peng-Hsu Chen, Edward Hsi, Chwen-Ming Shih, Wei‐Chiao Chang , et al. · 2017

Methylation in the Matrix Metalloproteinase-2 Gene is Associated with Cerebral Ischemic Stroke Open

Hsiu‐Fen Lin, Edward Hsi, Ling-Chun Huang, Yi‐Chu Liao, Suh-Hang Hank Juo , et al. · 2017

Matrix metalloproteinase-2 (MMP-2) is involved in the pathophysiology of stroke. Previous studies have shown that MMP-2 activity is increased in stroke; however, evidence of epigenetic regulation of the MMP-2 in stroke is still limited. We…

Micro<span>RNA</span> let‐7g possesses a therapeutic potential for peripheral artery disease Open

Po‐Yuan Hsu, Edward Hsi, Tzu‐Ming Wang, Ruey‐Tay Lin, Yi‐Chu Liao , et al. · 2016

Peripheral artery disease ( PAD ) is a manifestation of systemic atherosclerosis and conveys a significant health burden globally. Critical limb ischaemia encompasses the most severe consequence of PAD . Our previous studies indicate that …

Dynamics of PBMC gene expression in hepatitis C virus genotype 1-infected patients during combined peginterferon/ribavirin therapy Open

Ming‐Ying Lu, Ching‐I Huang, Ming‐Yen Hsieh, Tusty‐Jiuan Hsieh, Edward Hsi , et al. · 2016

Hepatitis C virus (HCV) can replicate in peripheral blood mononuclear cells (PBMCs), which can produce interferon to defend against virus infection. We hypothesized that dynamic gene expression in PBMCs might impact the treatment efficacy …

Aryl hydrocarbon receptor regulates histone deacetylase 8 expression to repress tumor suppressive activity in hepatocellular carcinoma Open

Li‐Ting Wang, Shyh-Shin Chiou, Chee‐Yin Chai, Edward Hsi, Shen-Nien Wang , et al. · 2016

[This corrects the article DOI: 10.18632/oncotarget.9841.].

Intestine-specific homeobox (ISX) upregulates E2F1 expression and related oncogenic activities in HCC Open

Shen-Nien Wang, Li‐Ting Wang, Ding‐Ping Sun, Chee‐Yin Chai, Edward Hsi , et al. · 2016

Intestine-specific homeobox (ISX), a newly identified proto-oncogene, is involved in cell proliferation and progression of hepatocellular carcinoma (HCC). However, the underlying mechanisms linking gene expression and tumor formation remai…

Demethylation of Circulating Estrogen Receptor Alpha Gene in Cerebral Ischemic Stroke Open

Hsiu‐Fen Lin, Edward Hsi, Yi‐Chu Liao, Brian Chhor, Jessica Hung , et al. · 2015

Female stroke cases have lower ERα methylation levels than those in the controls, especially in large-artery and cardio-embolic stroke subtypes. The study implies that women suffering from ischemic stroke of specific subtype may undergo di…

Quantitative Proteomic Analysis of Differentially Expressed Protein Profiles Involved in Pancreatic Ductal Adenocarcinoma Open

Kung‐Kai Kuo, Chao-Jen Kuo, Chiang-Yen Chiu, Shih‐Shin Liang, Chun‐Hao Huang , et al. · 2015

The systematic decrease or increase of these identified marker proteins may potentially reflect the morphological aberrations and diseased stages of pancreas carcinoma throughout progressive developments leading to PDAC. The results would …

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