Jo E. Lewis
YOU?
Author Swipe
View article: Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals
Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals Open
Animals respond to environmental cues to time phenological events, but the intrinsic mechanism of circannual timing remains elusive. We used transcriptomic sequencing and frequent sampling, during three distinct phases (induction, maintena…
View article: Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals
Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals Open
Animals respond to environmental cues to time phenological events, but the intrinsic mechanism of circannual timing remains elusive. We used transcriptomic sequencing and frequent sampling of multiple hypothalamic nuclei in Djungarian hams…
View article: Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals
Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals Open
Animals respond to environmental cues to time phenological events, but the intrinsic mechanism of circannual timing remains elusive. We used transcriptomic sequencing and frequent sampling of multiple hypothalamic nuclei in Djungarian hams…
View article: The role of GIPR in food intake control
The role of GIPR in food intake control Open
Glucose-dependent insulinotropic polypeptide (GIP) is one of two incretin hormones playing key roles in the control of food intake, nutrient assimilation, insulin secretion and whole-body metabolism. Recent pharmacological advances and cli…
View article: Activation of Gs signaling in mouse enteroendocrine K cells greatly improves obesity- and diabetes-related metabolic deficits
Activation of Gs signaling in mouse enteroendocrine K cells greatly improves obesity- and diabetes-related metabolic deficits Open
Following a meal, glucagon-like peptide 1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP), the 2 major incretins promoting insulin release, are secreted from specialized enteroendocrine cells (L and K cells, respectively). Al…
View article: Single-cell transcriptomic atlas of enteroendocrine cells along the murine gastrointestinal tract
Single-cell transcriptomic atlas of enteroendocrine cells along the murine gastrointestinal tract Open
Background Enteroendocrine cells (EECs) produce over 20 gut hormones which contribute to intestinal physiology, nutrient metabolism and the regulation of food intake. The objective of this study was to generate a comprehensive transcriptom…
View article: Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding
Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding Open
Central glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) signaling is critical in GIP-based therapeutics' ability to lower body weight, but pathways leveraged by GIPR pharmacology in the brain remain incompletely understo…
View article: 72 The importance of decision-making at end-of-life: A systematic review
72 The importance of decision-making at end-of-life: A systematic review Open
Introduction Caring for the dying is a multidisciplinary team (MDT) model of care, with nurses providing the most direct patient care. Providing end-of-life care to meet the person-centred needs of individuals and families is complex and r…
View article: Evidence for Involvement of GIP and GLP-1 Receptors and the Gut-Gonadal Axis in Regulating Female Reproductive Function in Mice
Evidence for Involvement of GIP and GLP-1 Receptors and the Gut-Gonadal Axis in Regulating Female Reproductive Function in Mice Open
Substantial evidence suggests crosstalk between reproductive and gut-axis but mechanisms linking metabolism and reproduction are still unclear. The present study evaluated the possible role of glucose-dependent-insulinotropic-polypeptide (…
View article: Loss of Function of the Neural Cell Adhesion Molecule NrCAM Regulates Differentiation, Proliferation and Neurogenesis in Early Postnatal Hypothalamic Tanycytes
Loss of Function of the Neural Cell Adhesion Molecule NrCAM Regulates Differentiation, Proliferation and Neurogenesis in Early Postnatal Hypothalamic Tanycytes Open
Hypothalamic tanycytes are neural stem and progenitor cells, but little is known of how they are regulated. Here we provide evidence that the cell adhesion molecule, NrCAM, regulates tanycytes in the adult niche. NrCAM is strongly expresse…
View article: Cold Exposure Drives Weight Gain and Adiposity following Chronic Suppression of Brown Adipose Tissue
Cold Exposure Drives Weight Gain and Adiposity following Chronic Suppression of Brown Adipose Tissue Open
Therapeutic activation of thermogenic brown adipose tissue (BAT) may be feasible to prevent, or treat, cardiometabolic disease. However, rodents are commonly housed below thermoneutrality (~20 °C) which can modulate their metabolism and ph…
View article: The physiology of obesity: from mechanisms to medicine (M2M). Part one
The physiology of obesity: from mechanisms to medicine (M2M). Part one Open
Over 1.9 billion adults worldwide are overweight or obese with an estimated annual cost of 1.2 trillion USD. Many individuals suffering from obesity also suffers from metabolic syndrome, type 2 diabetes and non-alcoholic fatty liver diseas…
View article: The neural cell adhesion molecule NrCAM regulates development of hypothalamic tanycytes
The neural cell adhesion molecule NrCAM regulates development of hypothalamic tanycytes Open
Hypothalamic tanycytes are neural stem and progenitor cells, but little is known of how they are regulated. Here we provide evidence that the cell adhesion molecule, NrCAM, regulates tanycytes in the adult niche. NrCAM is strongly expresse…
View article: Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice
Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice Open
Relaxin/insulin-like-family peptide receptor-4 (RXFP4), the cognate receptor for insulin-like peptide 5 (INSL5), has been implicated in feeding behaviour as Rxfp4 knockout mice display shorter meal durations and reduced high fat diet (HFD)…
View article: Gut peptide regulation of food intake - evidence for the modulation of hedonic feeding.
Gut peptide regulation of food intake - evidence for the modulation of hedonic feeding. Open
The number of people living with obesity has tripled worldwide since 1975 with serious implications for public health, as obesity is linked to a significantly higher chance of early death from associated comorbidities (metabolic syndrome, …
View article: Exercise Training in Obese Rats Does Not Induce Browning at Thermoneutrality and Induces a Muscle-Like Signature in Brown Adipose Tissue
Exercise Training in Obese Rats Does Not Induce Browning at Thermoneutrality and Induces a Muscle-Like Signature in Brown Adipose Tissue Open
Aim: Exercise training elicits diverse effects on brown (BAT) and white adipose tissue (WAT) physiology in rodents housed below their thermoneutral zone (i.e., 28-32°C). In these conditions, BAT is chronically hyperactive and, unlike human…
View article: Cold exposure drives weight gain and adiposity following chronic suppression of brown adipose tissue
Cold exposure drives weight gain and adiposity following chronic suppression of brown adipose tissue Open
Therapeutic activation of thermogenic brown adipose tissue (BAT) may be feasible to prevent, or treat, cardiometabolic disease. However, rodents are commonly housed below thermoneutrality (∼20°C) which can modulate their metabolism and phy…
View article: Photoperiodic changes in adiposity increase sensitivity of female Siberian hamsters to systemic VGF derived peptide TLQP-21
Photoperiodic changes in adiposity increase sensitivity of female Siberian hamsters to systemic VGF derived peptide TLQP-21 Open
TLQP-21, a peptide encoded by the highly conserved vgf gene, is expressed in neuroendocrine cells and has been the most prominent VGF-derived peptide studied in relation to control of energy balance. The recent discovery that TLQP-21 is th…
View article: Genome sequencing and transcriptome analyses of the Siberian hamster hypothalamus identify mechanisms for seasonal energy balance
Genome sequencing and transcriptome analyses of the Siberian hamster hypothalamus identify mechanisms for seasonal energy balance Open
Synthesis of triiodothyronine (T 3 ) in the hypothalamus induces marked seasonal neuromorphology changes across taxa. How species-specific responses to T 3 signaling in the CNS drive annual changes in body weight and energy balance remains…
View article: Exercise does not induce browning of WAT at thermoneutrality and induces an oxidative, myogenic signature in BAT
Exercise does not induce browning of WAT at thermoneutrality and induces an oxidative, myogenic signature in BAT Open
Background and aim Exercise training elicits diverse effects on brown (BAT) and white adipose tissue (WAT) physiology in rodents. However, these animals are typically housed below their thermoneutral zone (i.e. 28-32°C). In these condition…