Xiaochuan Li
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View article: The crystal structure of ( <b> <i>E</i> </b> )-4-chloro-7-(diethylamino)-3-(3-oxo-3-phenylprop-1-en-1-yl)-2 <i> <b>H</b> </i> -chromen-2-one C <sub>22</sub> H <sub>20</sub> ClNO <sub>3</sub>
The crystal structure of ( <b> <i>E</i> </b> )-4-chloro-7-(diethylamino)-3-(3-oxo-3-phenylprop-1-en-1-yl)-2 <i> <b>H</b> </i> -chromen-2-one C <sub>22</sub> H <sub>20</sub> ClNO <sub>3</sub> Open
C 22 H 20 ClNO 3 , monoclinic, P 2 1 / n (no. 14), a = 9.3891(4) Å, b = 11.0821(4) Å, c = 17.4662(5) Å, β = 98.361(3)°; V = 1798.06 Å 3 , Z = 4, R gt ( F ) = 0.0361, wR ref ( F 2 ) = 0.0911, T = 100 K.
View article: Exploring cervicovaginal microbiome differences between single and multiple endometrial polyps: implications for non-invasive classification
Exploring cervicovaginal microbiome differences between single and multiple endometrial polyps: implications for non-invasive classification Open
Single and multiple endometrial polyps (EP) are common gynecological conditions with differing recurrence rates, influencing clinical treatment decisions. This study aimed to characterize the reproductive tract microbiome in both subtypes …
View article: Mitsugumin 53 drives stem cell differentiation easing intestinal injury and inflammation
Mitsugumin 53 drives stem cell differentiation easing intestinal injury and inflammation Open
Emerging evidence suggests that priming intestinal stem cells (ISCs) towards secretory progenitor cells is beneficial for maintaining gut homeostasis against inflammatory bowel disease (IBD). However, the mechanism driving such biased line…
View article: Integrated transcriptomic and immune profiling reveals crucial molecular pathways and hub genes associated with postoperative delirium in elderly patients
Integrated transcriptomic and immune profiling reveals crucial molecular pathways and hub genes associated with postoperative delirium in elderly patients Open
Background Postoperative delirium (POD) manifests as severe mental disorientation, often experienced by elderly patients undergoing surgery, significantly hindering recovery and deteriorating the quality of life. Despite numerous clinical …
View article: An antibody-dependent cellular phagocytosis-related gene signature predicts survival and response to immunotherapy in stomach adenocarcinoma
An antibody-dependent cellular phagocytosis-related gene signature predicts survival and response to immunotherapy in stomach adenocarcinoma Open
Antibody-dependent cellular phagocytosis (ADCP) is an immune biological process and plays a biological role in the clearance of tumor cells and the response to immune checkpoint inhibitors. However, the effects of ADCP on stomach adenocarc…
View article: Hydrogen Bonding–Induced Multicolor and Thermochromic Emissions of Triphenylamines
Hydrogen Bonding–Induced Multicolor and Thermochromic Emissions of Triphenylamines Open
The fluorescence tuning of stimuli‐responsive materials is crucial but challenging. The deep understanding of thermal induced fluorescence change, however, has rarely been conducted. Herein, the thermochromic emission of a triphenylamine (…
View article: Reproductive tract microbiome dysbiosis associated with gynecological diseases
Reproductive tract microbiome dysbiosis associated with gynecological diseases Open
Female health and the microbiota of the reproductive tract are closely associated. The research scope on reproductive tract microbiota extends from the vaginal to the upper reproductive tract and from infectious diseases to various benign …
View article: Experimental Study on Mechanical Properties of Solidified Soft Loose Soil
Experimental Study on Mechanical Properties of Solidified Soft Loose Soil Open
View article: Experimental study on the correlation between droplet distribution and dust removal efficiency of a novel atomizing nozzle
Experimental study on the correlation between droplet distribution and dust removal efficiency of a novel atomizing nozzle Open
View article: Author Correction: Activation of GPR81 by lactate drives tumour-induced cachexia
Author Correction: Activation of GPR81 by lactate drives tumour-induced cachexia Open
View article: Activation of GPR81 by lactate drives tumour-induced cachexia
Activation of GPR81 by lactate drives tumour-induced cachexia Open
View article: VT204: A Potential Small Molecule Inhibitor Targeting KRASG12C Mutation for Therapeutic Intervention in Non-Small Cell Lung Cancer
VT204: A Potential Small Molecule Inhibitor Targeting KRASG12C Mutation for Therapeutic Intervention in Non-Small Cell Lung Cancer Open
Objectives: The development of effective treatments for non-small cell lung cancer (NSCLC), particularly targeting the KRASG12C mutation, remains a challenge. In this study, we investigated the therapeutic potential of VT204, a small molec…
View article: Recent Progress on Hydrogen Production from Ammonia Decomposition: Technical Roadmap and Catalytic Mechanism
Recent Progress on Hydrogen Production from Ammonia Decomposition: Technical Roadmap and Catalytic Mechanism Open
Ammonia decomposition has attracted significant attention in recent years due to its ability to produce hydrogen without emitting carbon dioxide and the ease of ammonia storage. This paper reviews the recent developments in ammonia decompo…
View article: Diazo-carboxyl click chemistry enables rapid and sensitive quantification of carboxylic acid metabolites
Diazo-carboxyl click chemistry enables rapid and sensitive quantification of carboxylic acid metabolites Open
Carboxylic acids are central metabolites in bioenergetics, signal transduction and post-translation protein regulation. Unlike its genomic and transcriptomic counterparts, the quest for metabolomic profiling in trace amounts of biomedical …
View article: CCDC 1866650: Experimental Crystal Structure Determination
CCDC 1866650: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1832311: Experimental Crystal Structure Determination
CCDC 1832311: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1864640: Experimental Crystal Structure Determination
CCDC 1864640: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1864699: Experimental Crystal Structure Determination
CCDC 1864699: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1864702: Experimental Crystal Structure Determination
CCDC 1864702: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Boosting Visible-Light Photocatalytic Hydrogen Evolution Over Layered Perovskite by Incorporating CDS Quantum Dots
Boosting Visible-Light Photocatalytic Hydrogen Evolution Over Layered Perovskite by Incorporating CDS Quantum Dots Open
View article: Quantification of VT204 in rat plasma by LC-MS/MS and its pharmacokinetic study
Quantification of VT204 in rat plasma by LC-MS/MS and its pharmacokinetic study Open
Although the target of KRAS G12C is no longer unbreakable, resistance to current drugs against KRAS G12C occurs. The emergence of a new drug, VT204, is expected to be a new clinical drug in this field. Preclinical pharmacokinetic (PK) stud…
View article: Macrophage polarization regulates intervertebral disc degeneration by modulating cell proliferation, inflammation mediator secretion, and extracellular matrix metabolism
Macrophage polarization regulates intervertebral disc degeneration by modulating cell proliferation, inflammation mediator secretion, and extracellular matrix metabolism Open
Macrophage infiltration and polarization have been increasingly observed in intervertebral disc (IVD) degeneration (IDD). However, their biological roles in IDD are still unrevealed. We harvested conditioned media (CM) derived from a spect…
View article: CCDC 2080820: Experimental Crystal Structure Determination
CCDC 2080820: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Crystal structure of 2-bromo-1,3,6,8-tetramethylBOPHY (BOPHY = bis(difluoroboron)-1,2-bis((1<i>H</i>-pyrrol-2-yl)methylene)hydrazine), C<sub>14</sub>H<sub>15</sub>B<sub>2</sub>BrF<sub>4</sub>N<sub>4</sub>
Crystal structure of 2-bromo-1,3,6,8-tetramethylBOPHY (BOPHY = bis(difluoroboron)-1,2-bis((1<i>H</i>-pyrrol-2-yl)methylene)hydrazine), C<sub>14</sub>H<sub>15</sub>B<sub>2</sub>BrF<sub>4</sub>N<sub>4</sub> Open
C 14 H 15 B 2 BrF 4 N 4 , orthorhombic, Pbca (no. 61), a = 11.970(1) Å, b = 10.049(1) Å, c = 27.847(1) Å, V = 3349.6 Å 3 , Z = 8, R gt ( F ) = 0.0697, wR ref ( F 2 ) = 0.1585, T = 296 K. CCDC no.: 2080820
View article: M2 Macrophage-Conditioned Medium Inhibits Intervertebral Disc Degeneration in a Tumor Necrosis Factor-α-rich Environment
M2 Macrophage-Conditioned Medium Inhibits Intervertebral Disc Degeneration in a Tumor Necrosis Factor-α-rich Environment Open
BackgroundInflammation is the primary pathological phenomenon associated with disc degeneration; accordingly, the inflammatory cytokine tumor necrosis factor (TNF-α) plays a crucial role in disc degeneration. M1 macrophages produce proinfl…
View article: Crystal structure of 2-phenylethynyl-1,3,6,8-tetramethylBOPHY (BOPHY = bis(difluoroboron)-1,2-bis((1<i>H</i>-pyrrol-2-yl)methylene)hydrazine), C<sub>22</sub>H<sub>20</sub>B<sub>2</sub>F<sub>4</sub>N<sub>4</sub>
Crystal structure of 2-phenylethynyl-1,3,6,8-tetramethylBOPHY (BOPHY = bis(difluoroboron)-1,2-bis((1<i>H</i>-pyrrol-2-yl)methylene)hydrazine), C<sub>22</sub>H<sub>20</sub>B<sub>2</sub>F<sub>4</sub>N<sub>4</sub> Open
C 22 H 20 B 2 F 4 N 4 , orthorhombic, Pbca (no. 61), a = 9.2506(2) Å, b = 36.1677(13) Å, c = 12.9475(3) Å, V = 4331.9 Å 3 , Z = 8, R gt ( F ) = 0.0729, wR ref ( F 2 ) = 0.1992, T = 294.4 K.
View article: Expression and Distribution of M1 and M2 Macrophages in the Degeneration Process of Human Lumbar Intervertebral Disc Herniation: A Histological and Clinical Efficacy Analysis
Expression and Distribution of M1 and M2 Macrophages in the Degeneration Process of Human Lumbar Intervertebral Disc Herniation: A Histological and Clinical Efficacy Analysis Open
Background: Macrophages were previously proved to participate in the progression of lumbar disc herniation (LDH), but the phenotypic subtypes of macrophages and the association between M1/M2 positivity and clinical efficacy in LDH are not …
View article: High-intensity interval training for heart failure with preserved ejection fraction
High-intensity interval training for heart failure with preserved ejection fraction Open
Background: The benefits of high-intensity interval training (HIIT) are well-known, there is insufficient evidence about the effects of HIIT on heart failure with preserved ejection fraction (HFpEF). Method: Multiple databases include MEDL…
View article: Natural products as LSD1 inhibitors for cancer therapy
Natural products as LSD1 inhibitors for cancer therapy Open
Natural products generally fall into the biologically relevant chemical space and always possess novel biological activities, thus making them a rich source of lead compounds for new drug discovery. With the recent technological advances, …
View article: CCDC 1953718: Experimental Crystal Structure Determination
CCDC 1953718: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …