Explanipedia

SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL Open

Mi Zhang, Chanyuan Chen, Haifeng Zhang, Timothy E. Long, Tingjie Wang , et al. · 2025

Background SIRT6 acts as a tumour suppressor in multiple cancers by regulating glucose and lipid metabolism, but its role in intrahepatic cholangiocarcinoma (ICC) remains unclear. Objective We investigated the role and molecular mechanisms…

Morphological and Computational Analysis of Additively Manufacturable Polyimide Precursors: Implications for Rationally Designing New Polyimide Structures Open

Erin R. Crater, Carl Fossum, John W. Will, Cody W. Weyhrich, Garrett F. Godshall , et al. · 2025

In this work, photocurable polyimide precursors are additively manufactured via vat photopolymerization and thermally post‐processed into bulk polyimide discs. Two polyimide structural variants were additively manufactured, post‐processed,…

3D bioprinting for human-relevant toxicology: Advanced organ models and translational strategies Open

Yinpeng Le, Timothy E. Long, Qi Wang, Mengxiong Tang, Mingyue Pan , et al. · 2025

Traditional toxicological testing, which relies on animal models and 2D cell cultures, encounters challenges in accurately predicting human-specific responses owing to interspecies variability and the oversimplified nature of in vitro syst…

Enabling Additively Manufactured Electronics Through Laser Induced Graphene and Copper Deposition on Fully‐Aromatic Polyimides Open

Heather D. Wotton, Ravi Tutika, John W. Will, Dong Hae Ho, Michael D. Bartlett , et al. · 2025

Additively manufactured electronics (AME) have enabled the integration of electrical functionality into printed parts to form multifunctional components. Current AME approaches focus on hybridizing additive manufacturing (AM) with direct w…

Vat Photopolymerization of High Molecular Weight Polymer Latexes with <i>Pseudothermoplastic</i> Properties for Recyclability Open

Jon Ayestarán, Xabier Lopez de Pariza, Fernando Vidal, Clara Vazquez‐Martel, Alodi Pascal , et al. · 2025

Additive manufacturing (AM), or 3D printing, has rapidly advanced due to its customization, speed, and precision manufacturing. Traditional vat photopolymerization (VPP) often produces densely cross‐linked, brittle, and non‐reprocessable m…

Designing Surfactants for Fuel Resistance: Linking Foam Stability, Micelle Behavior, and Molecular Architecture Open

Anon. Anon., Margaret D. Madsen, Timothy E. Long, Rui Qiao, Brian Y. Lattimer · 2025

Design and Depolymerization of Bis(2‐hydroxyethyl) Terephthalate‐Containing Polyurethanes for Vat Photopolymerization Open

Clarissa C. Westover, Garvit Nayyar, Timothy E. Long · 2024

Vat photopolymerization (VPP) of highly aromatic polyurethanes (PUs) expands the library of additive manufacturing (AM) materials and enables a vast array of ductile thermoplastics, rigid and flexible thermosets, and elastomers. Aromatic d…

Economic potential of field peas as an alternative to corn distillers dried grains with solubles in beef heifer growing diets Open

Michael Undi, Jon T. Biermacher, Kevin K. Sedivec, Timothy E. Long · 2024

Functional Upcycling of Polyurethane Thermosets into Value-Added Thermoplastics via Small-Molecule Carbamate-Assisted Decross-Linking Extrusion Open

Jared A. Nettles, Saleh Alfarhan, Cameron A. Pascoe, Clarissa C. Westover, Margaret D. Madsen , et al. · 2024

The cross-linked structures of most commodity polyurethanes (PUs) hinder their recycling by common mechanical/chemical approaches. Catalyzed dynamic carbamate exchange emerges as a promising PU recycling strategy, which converts traditiona…

Vat photopolymerization of olefinic elastomers from sulfonated ethylene-propylene-diene monomer (EPDM) latexes Open

Jianheng Wen, Garvit Nayyar, Erin R. Crater, Ren H. Bean, Rui Zhang , et al. · 2024

Vat photopolymerization of poly(styrene-b-isoprene-b-styrene) triblock copolymers Open

Ren H. Bean, Garvit Nayyar, Margaret K. Brown, Jianheng Wen, Yiqun Fu , et al. · 2024

Characterizing photopolymer resins for high-temperature vat photopolymerization Open

Viswanath Meenakshisundaram, Keyton D. Feller, Nicholas Chartrain, Timothy E. Long, Christopher B. Williams · 2024

The availability of engineering polymers for vat photopolymerization (VP) additive manufacturing is limited. This limitation primarily stems from the inability of standard VP systems to recoat high-viscosity resins (> 3 Pa s). High-tempera…

Vat Photopolymerization of Olefinic Elastomers from Sulfonated Ethylene-Propylene-Diene Monomer (Epdm) Latexes Open

Jianheng Wen, Garvit Nayyar, Erin R. Crater, Ren H. Bean, Rui Zhang , et al. · 2024

Envisioning a BHET Economy: Adding Value to PET Waste Open

Clarissa C. Westover, Timothy E. Long · 2023

Poly(ethylene terephthalate), the fifth most produced polymer, generates significant waste annually. This increased waste production has spurred interest in chemical and mechanical pathways for recycling. The shift from laboratory settings…

Temporally Stable Supramolecular Polymeric Salts Enabling High‐Performance 3D All‐Aromatic Polyimide Lattices Open

Cody W. Weyhrich, John W. Will, Garvit Nayyar, Clarissa C. Westover, Steven Patterson , et al. · 2023

Vat photopolymerization (VP) Additive Manufacturing (AM), in which UV light is selectively applied to cure photo‐active polymers into complex geometries with micron‐scale resolution, has a limited selection of aliphatic thermoset materials…

Rheology guiding the design and printability of aqueous colloidal composites for additive manufacturing Open

Ren H. Bean, Daniel A. Rau, Christopher B. Williams, Timothy E. Long · 2023

Vat photopolymerization (VP) and direct ink write (DIW) additive manufacturing (AM) provide complex geometries with precise spatial control employing a vast array of photo‐reactive polymeric systems. Although VP is recognized for superior …

Development of a Synthetic, Injectable Hydrogel to Capture Residual Glioblastoma and Glioblastoma Stem‐Like Cells with CXCL12‐Mediated Chemotaxis Open

Zerin Mahzabin Khan, Jennifer M. Munson, Timothy E. Long, Eli Vlaisavljevich, Scott S. Verbridge · 2023

Glioblastoma (GBM), characterized by high infiltrative capacity, is the most common and deadly type of primary brain tumor in adults. GBM cells, including therapy‐resistant glioblastoma stem‐like cells (GSCs), invade the healthy brain pare…

Polymer Colloids: Current Challenges, Emerging Applications, and New Developments Open

Miren Aguirre, Nicholas Ballard, Edurne González, Shaghayegh Hamzehlou, Haritz Sardón , et al. · 2023

Polymer colloids are complex materials that have the potential to be used in a vast array of applications. One of the main reasons for their continued growth in commercial use is the water-based emulsion polymerization process through whic…

Non-Isocyanate Polyurethane Microcellular Structures from Bis-Carbonylimidizolide Decarboxylation Open

Jose Sintas, Timothy E. Long · 2022

a thermoplastic non-isocyanate polyurethane. The lignin-oil is first converted to a cyclocarbonated derivative using a benign synthetic sequence and further polymerized with a diamine to yield the non-isocyanate TPU. While more work is und…

Tunable Non-Isocyanate Polyurethane Foams for Rigid and Soft Applications Open

Jose Sintas, Timothy E. Long · 2022

and the necessity of employing extensive purification and/or functionalization measures to ensure materials are of comparable quality. In this report, a unique method is presented for the synthesis and processing of a non-toxic, non-isocya…

Bringing to Life a Newly Discovered Signature of Fatigue Crack Initiation via Multimodal Characterizations Open

Dalton Shadle, Kelly E. Nygren, Jean Stinville, Marie A. Charpagne, Timothy E. Long , et al. · 2022

Fatigue is the most prevalent failure mode in structural materials, yet remains challenging to study due to the seemingly unpredictable nature of crack initiation. To elucidate the driving forces of crack initiation in ductile polycrystall…

Quadruple Hydrogen Bond-Containing A-AB-A Triblock Copolymers: Probing the Influence of Hydrogen Bonding in the Central Block Open

Boer Liu, Xi Chen, Glenn A. Spiering, Robert B. Moore, Timothy E. Long · 2021

This work reveals the influence of pendant hydrogen bonding strength and distribution on self-assembly and the resulting thermomechanical properties of A-AB-A triblock copolymers. Reversible addition-fragmentation chain transfer polymeriza…

Ageing of PBF‐Grade Poly(Phenylene Sulfide) Powder and its Effect on Critical Printability Properties Open

Camden A. Chatham, Arit Das, Timothy E. Long, Michael J. Bortner, Christopher B. Williams · 2021

Poly(phenylene sulfide) (PPS) is a high‐performance polymer suiting the needs of powder bed fusion (PBF) early‐adopter industries. Although there are many benefits to PBF's powder bed‐based, one drawback is thermal ageing of the powder not…

Predicting mechanical property plateau in laser polymer powder bed fusion additive manufacturing via the critical coalescence ratio Open

Camden A. Chatham, Michael J. Bortner, Blake N. Johnson, Timothy E. Long, Christopher B. Williams · 2021

Predicting Mechanical Property Plateau in Laser Polymer Powder Bed Fusion Additive Manufacturing via the Critical Coalescence Ratio Open

Camden A. Chatham, Michael J. Bortner, Blake N. Johnson, Timothy E. Long, Christopher B. Williams · 2021

Phosphonium-Based Polyzwitterions: Influence of Ionic Structure and Association on Mechanical Properties Open

Philip J. Scott, Glenn A. Spiering, Yangyang Wang, Zach D. Seibers, Robert B. Moore , et al. · 2020

This manuscript describes a synthetic strategy and structure–property investigation of unprecedented phosphonium-based zwitterionic homopolymers (polyzwitterions) and random copolymers (zwitterionomers). Free radical polymerization of 4-(d…

RAFT polymerization of temperature- and salt-responsive block copolymers as reversible hydrogels Open

Sean T. Hemp, Adam E. Smith, W. Clayton Bunyard, Michael Rubinstein, Timothy E. Long · 2020

Reversible-addition fragmentation chain transfer (RAFT) polymerization enabled the synthesis of novel, stimuli-responsive, AB and ABA block copolymers. The B block contained oligo(ethylene glycol) methyl ether methacrylate (OEG) and was pe…

Isocyanate- and solvent-free synthesis of melt processible polyurea elastomers derived from urea as a monomer Open

B. Tyler White, John M. Migliore, Emmanuel Urandu Mapesa, Josh D. Wolfgang, Joshua Sangoro , et al. · 2020

Polyurea elastomers derived in part from a bio-sourced feedstock and synthesized using an isocyanate-, solvent-, and catalyst-free approach exhibit elastomeric properties while maintaining melt-processibility.

Powder bed fusion of poly(phenylene sulfide) at bed temperatures significantly below melting Open

Camden A. Chatham, Timothy E. Long, Christopher B. Williams · 2019

3D Printing Amorphous Polysiloxane Terpolymers via Vat Photopolymerization Open

Justin M. Sirrine, Alisa Zlatanić, Viswanath Meenakshisundaram, Jamie M. Messman, Christopher B. Williams , et al. · 2019

Photocuring and vat photopolymerization (VP) additive manufacturing (AM) is reported for two families of fully amorphous poly(dimethyl siloxane) (PDMS) terpolymers containing either diphenylsiloxy (DiPhS) or diethylsiloxy (DiEtS) repeating…

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