Explanipedia

Acro-osteolysis in systemic sclerosis is associated with digital ischaemia and severe calcinosis Open

Edward M. Johnstone, Charles Hutchinson, Andy Vail, Astrid Chevance, Ariane L. Herrick · 2012

Acro-osteolysis was strongly associated with severe digital ischaemia. The potential association with severe calcinosis merits further study. Prospective studies are required to investigate acro-osteolysis as a marker of digital vascular d…

Development of an Immunofluorometric Assay and Quantification of Human Kallikrein 7 in Tissue Extracts and Biological Fluids Open

Tadaaki Kishi, Antoninus Soosaipillai, Linda Grass, Sheila P. Little, Edward M. Johnstone , et al. · 2004

Background: Human kallikrein 7 (hK7), also known as human stratum corneum chymotryptic enzyme, is a chymotrypsin-like serine protease first identified in human skin extracts and predicted to be a secreted protease. The aim of this study wa…

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain Open

Harry F. Dovey, Varghese John, J. P. Anderson, L. Z. Chen, P. D. S. int Andrieu , et al. · 2001

Converging lines of evidence implicate the beta‐amyloid peptide (Aβ) as causative in Alzheimer's disease. We describe a novel class of compounds that reduce Aβ production by functionally inhibiting γ‐secretase, the activity responsible for…

Rat B2 Sequences Are Induced in the Hippocampal CA1 Region After Transient Global Cerebral Ischemia Open

Xiaodong Liu, James A. Clemens, Tinggui Yin, Diane Stephenson, Edward M. Johnstone , et al. · 1999

Global brain ischemia causes cell death in the CA1 region of the hippocampus 3-5 days after reperfusion. The biological pathway leading to such delayed neuronal damage has not been established. By using differential display analysis, we ex…

Zyme, a Novel and Potentially Amyloidogenic Enzyme cDNA Isolated from Alzheimer's Disease Brain Open

Sheila P. Little, Eric P. Dixon, Frank A. Norris, William Buckley, Gerald W. Becker , et al. · 1997

The deposition of the beta amyloid peptide in neuritic plaques and cerebral blood vessels is a hallmark of Alzheimer's disease (AD) pathology. The major component of the amyloid deposit is a 4.2-kDa polypeptide termed amyloid beta-protein …

Thrombin Induces Activation of p38 MAP Kinase in Human Platelets Open

Ruth M. Kramer, Edda F. Roberts, Beth A. Strifler, Edward M. Johnstone · 1995

In human platelets a proline-directed kinase distinct from the ERK MAP kinases is stimulated by both thrombin and the thrombin receptor agonist peptide SFLLRN and may be involved in the activation of Ca(2+)-dependent cytosolic phospholipas…

Induction of tissue-specific proline-rich protein multigene families in rat and mouse parotid glands by isoproterenol. Unusual strain differences of proline-rich protein mRNAs. Open

David K. Ann, Scott Clements, Edward M. Johnstone, Don M. Carlson · 1987

A dramatic induction of proline-rich protein mRNAs by the beta-agonist isoproterenol in the parotid and submandibular glands of both rats and mice has been demonstrated using Northern and dot-blot hybridizations and cell-free translation. …

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