Matthew E. Rogers
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View article: Sand fly saliva reprograms skin fibroblasts to enhance arbovirus infection
Sand fly saliva reprograms skin fibroblasts to enhance arbovirus infection Open
Summary: Arbovirus transmission by sand flies is a growing public health concern, yet the early skin events shaping infection outcomes remain undefined. We establish a mouse model of Toscana virus (TOSV) infection that incorporates sand fl…
View article: Exploiting nectar and blood feeding cues and phagostimulants to optimise Attractive Targeted Sugar Baits against a sand fly vector of leishmaniasis
Exploiting nectar and blood feeding cues and phagostimulants to optimise Attractive Targeted Sugar Baits against a sand fly vector of leishmaniasis Open
Background Leishmaniasis presents a major public health problem for a large number of countries requiring effective integrated management of the vector, sand flies, for sustained control. Such strategies need to be economically and environ…
View article: Gels and cells: the Leishmania biofilm as a space and place for parasite transmission
Gels and cells: the Leishmania biofilm as a space and place for parasite transmission Open
Leishmania make an abundant glycoprotein and proteophosphoglycan-rich gel, called the promastigote secretory gel, in the anterior midgut of their sand fly vector. This gel is a multi-faceted virulence factor which promotes the survival and…
View article: Comparison of collection methods for Phlebotomus argentipes sand flies to use in a molecular xenomonitoring system for the surveillance of visceral leishmaniasis
Comparison of collection methods for Phlebotomus argentipes sand flies to use in a molecular xenomonitoring system for the surveillance of visceral leishmaniasis Open
Background The kala-azar elimination programme has resulted in a significant reduction in visceral leishmaniasis (VL) cases across the Indian Subcontinent. To detect any resurgence of transmission, a sensitive cost-effective surveillance s…
View article: C-reactive protein binds to short phosphoglycan repeats of Leishmania secreted proteophosphoglycans and activates complement
C-reactive protein binds to short phosphoglycan repeats of Leishmania secreted proteophosphoglycans and activates complement Open
Human C-reactive protein (CRP) binds to lipophosphoglycan (LPG), a virulence factor of Leishmania spp., through the repeating phosphodisaccharide region. We report here that both major components of promastigote secretory gel (PSG), the fi…
View article: Temperature dependence of magnetic anisotropy and domain wall tuning in BaTiO3(111)/CoFeB multiferroics
Temperature dependence of magnetic anisotropy and domain wall tuning in BaTiO3(111)/CoFeB multiferroics Open
Artificial multiferroics consist of two types of ferroic materials, typically a ferroelectric and ferromagnet, often coupled interfacially by magnetostriction induced by the lattice elongations in the ferroelectric. In BaTiO3 the magnitude…
View article: Comparison of collection methods for<i>Phlebotomus argentipes</i>sand flies to use in a molecular xenomonitoring system for the surveillance of visceral leishmaniasis
Comparison of collection methods for<i>Phlebotomus argentipes</i>sand flies to use in a molecular xenomonitoring system for the surveillance of visceral leishmaniasis Open
Background The kala-azar elimination programme has resulted in a significant reduction in visceral leishmaniasis (VL) cases across the Indian Subcontinent. To detect any resurgence of transmission, a sensitive cost-effective surveillance s…
View article: Fetal Loss and Preterm Birth Caused by Intraamniotic <i>Haemophilus influenzae</i> Infection, New Zealand
Fetal Loss and Preterm Birth Caused by Intraamniotic <i>Haemophilus influenzae</i> Infection, New Zealand Open
Invasive Haemophilus influenzae infection during pregnancy can cause preterm birth and fetal loss, but the mechanism is unclear. We investigated 54 cases of pregnancy-associated invasive H. influenzae disease in 52 unique pregnancies in th…
View article: Micro-CT visualization of a promastigote secretory gel (PSG) and parasite plug in the digestive tract of the sand fly Lutzomyia longipalpis infected with Leishmania mexicana
Micro-CT visualization of a promastigote secretory gel (PSG) and parasite plug in the digestive tract of the sand fly Lutzomyia longipalpis infected with Leishmania mexicana Open
Leishmaniasis is a debilitating disease of the tropics, subtropics and southern Europe caused by Leishmania parasites that are transmitted during blood feeding by phlebotomine sand flies (Diptera: Psychodidae). Using non-invasive micro-com…
View article: <scp>Micro‐CT</scp> imaging of <i>Onchocerca</i> infection of <i>Simulium damnosum s.l</i> . blackflies and comparison of the peritrophic membrane thickness of forest and savannah flies
<span>Micro‐CT</span> imaging of <i>Onchocerca</i> infection of <i>Simulium damnosum s.l</i> . blackflies and comparison of the peritrophic membrane thickness of forest and savannah flies Open
Onchocerciasis is a neglected tropical disease (NTD) caused by Onchocerca Diesing 1841 (Spirurida: Onchocercidae) nematodes transmitted by blackflies. It is associated with poverty and imposes a significant health, welfare and economic bur…
View article: Insights into the salivary N-glycome of Lutzomyia longipalpis, vector of visceral leishmaniasis
Insights into the salivary N-glycome of Lutzomyia longipalpis, vector of visceral leishmaniasis Open
During Leishmania transmission sand flies inoculate parasites and saliva into the skin of vertebrates. Saliva has anti-haemostatic and anti-inflammatory activities that evolved to facilitate bloodfeeding, but also modulate the host’s immun…
View article: Insights into the salivary<i>N</i>-glycome of<i>Lutzomyia longipalpis</i>, vector of visceral leishmaniasis
Insights into the salivary<i>N</i>-glycome of<i>Lutzomyia longipalpis</i>, vector of visceral leishmaniasis Open
During Leishmania transmission sand flies inoculate parasites and saliva into the skin of vertebrates. Saliva has anti-haemostatic and anti-inflammatory activities that evolved to facilitate bloodfeeding, but also modulate the host’s immun…
View article: Odorant Receptor Inhibition Is Fundamental to Odor Encoding
Odorant Receptor Inhibition Is Fundamental to Odor Encoding Open
View article: Prediction of condition-specific regulatory genes using machine learning
Prediction of condition-specific regulatory genes using machine learning Open
Recent advances in genomic technologies have generated data on large-scale protein–DNA interactions and open chromatin regions for many eukaryotic species. How to identify condition-specific functions of transcription factors using these d…
View article: Glycan–glycan interactions determine <i>Leishmania</i> attachment to the midgut of permissive sand fly vectors
Glycan–glycan interactions determine <i>Leishmania</i> attachment to the midgut of permissive sand fly vectors Open
Force spectroscopy was used to measure the adhesion of Leishmania to synthetic mimics of galectins on the sand fly midgut.
View article: Odorant Receptor Inhibition is Fundamental to Odor Encoding
Odorant Receptor Inhibition is Fundamental to Odor Encoding Open
SUMMARY Most natural odors are complex mixtures of many volatile components, competing to bind odorant receptors (ORs) expressed in olfactory sensory neurons (OSNs) of the nose. To date surprisingly little is known about how OR antagonism …
View article: Promastigote secretory gel from natural and unnatural sand fly vectors exacerbate<i>Leishmania major</i>and<i>Leishmania tropica</i>cutaneous leishmaniasis in mice
Promastigote secretory gel from natural and unnatural sand fly vectors exacerbate<i>Leishmania major</i>and<i>Leishmania tropica</i>cutaneous leishmaniasis in mice Open
Leishmania rely heavily on glycans to complete their digenetic life cycle in both mammalian and phlebotomine sand fly hosts. Leishmania promastigotes secrete a proteophosphoglycan-rich gel (Promastigote Secretory Gel, PSG) that is regurgit…
View article: Quantifying Leishmania Metacyclic Promastigotes from Individual Sandfly Bites Reveals the Efficiency of Vector Transmission
Quantifying Leishmania Metacyclic Promastigotes from Individual Sandfly Bites Reveals the Efficiency of Vector Transmission Open
View article: Odorant Receptor Inhibition is Fundamental to Odor Encoding
Odorant Receptor Inhibition is Fundamental to Odor Encoding Open
View article: Establishment of a method for Lutzomyia longipalpis sand fly egg microinjection: The first step towards potential novel control strategies for leishmaniasis
Establishment of a method for Lutzomyia longipalpis sand fly egg microinjection: The first step towards potential novel control strategies for leishmaniasis Open
Leishmaniases is a group of vector-borne parasitic diseases transmitted by sand flies that affects 1.3 million people across 98 countries, with limited control strategies due to the lack of an available vaccine and the emergence of insecti…
View article: Establishment of a method for Lutzomyia longipalpis sand fly embryo microinjection: The first step towards potential novel control strategies for leishmaniasis
Establishment of a method for Lutzomyia longipalpis sand fly embryo microinjection: The first step towards potential novel control strategies for leishmaniasis Open
Leishmaniasis is a vector-borne parasitic disease transmitted by sand flies that affects 1.3 million people across 98 countries, with limited control strategies due to the lack of an available vaccine and the emergence of insecticide resis…
View article: Engineered microfluidic bioreactor for examining the three-dimensional breast tumor microenvironment
Engineered microfluidic bioreactor for examining the three-dimensional breast tumor microenvironment Open
The interaction of cancer cells with the stromal cells and matrix in the tumor microenvironment plays a key role in progression to metastasis. A better understanding of the mechanisms underlying these interactions would aid in developing n…
View article: Leishmania proteophosphoglycans regurgitated from infected sand flies accelerate dermal wound repair and exacerbate leishmaniasis via insulin-like growth factor 1-dependent signalling
Leishmania proteophosphoglycans regurgitated from infected sand flies accelerate dermal wound repair and exacerbate leishmaniasis via insulin-like growth factor 1-dependent signalling Open
Leishmania parasites are transmitted to vertebrate hosts by female phlebotomine sand flies as they bloodfeed by lacerating the upper capillaries of the dermis with their barbed mouthparts. In the sand fly midgut secreted proteophosphoglyca…
View article: Antibody response to sand fly saliva is a marker of transmission intensity but not disease progression in dogs naturally infected with Leishmania infantum
Antibody response to sand fly saliva is a marker of transmission intensity but not disease progression in dogs naturally infected with Leishmania infantum Open
View article: Combining epidemiology with basic biology of sand flies, parasites, and hosts to inform leishmaniasis transmission dynamics and control
Combining epidemiology with basic biology of sand flies, parasites, and hosts to inform leishmaniasis transmission dynamics and control Open
Quantitation of the nonlinear heterogeneities in Leishmania parasites, sand fly vectors, and mammalian host relationships provides insights to better understand leishmanial transmission epidemiology towards improving its control. The paras…
View article: MouSensor: A Versatile Genetic Platform to Create Super Sniffer Mice for Studying Human Odor Coding
MouSensor: A Versatile Genetic Platform to Create Super Sniffer Mice for Studying Human Odor Coding Open
View article: Understanding the transmission dynamics of Leishmania donovani to provide robust evidence for interventions to eliminate visceral leishmaniasis in Bihar, India the LCNTDR Collection: Advances in scientific research for NTD control
Understanding the transmission dynamics of Leishmania donovani to provide robust evidence for interventions to eliminate visceral leishmaniasis in Bihar, India the LCNTDR Collection: Advances in scientific research for NTD control Open
Visceral Leishmaniasis (VL) is a neglected vector-borne disease. In India, it is transmitted to humans by Leishmania donovani-infected Phlebotomus argentipes sand flies. In 2005, VL was targeted for elimination by the governments of India,…
View article: Understanding the transmission dynamics of Leishmania donovani to provide robust evidence for interventions to eliminate visceral leishmaniasis in Bihar, India
Understanding the transmission dynamics of Leishmania donovani to provide robust evidence for interventions to eliminate visceral leishmaniasis in Bihar, India Open
View article: In Vitro Mutational Analysis of the β2 Adrenergic Receptor, an In Vivo Surrogate Odorant Receptor
In Vitro Mutational Analysis of the β2 Adrenergic Receptor, an In Vivo Surrogate Odorant Receptor Open
Many G-protein coupled receptors (GPCRs), such as odorant receptors (ORs), cannot be characterized in heterologous cells because of their difficulty in trafficking to the plasma membrane. In contrast, a surrogate OR, the GPCR mouse β2-adre…
View article: Mechanics regulates ATP-stimulated collective calcium response in fibroblast cells
Mechanics regulates ATP-stimulated collective calcium response in fibroblast cells Open
Cells constantly sense their chemical and mechanical environments. We study the effect of mechanics on the ATP-induced collective calcium response of fibroblast cells in experiments that mimic various tissue environments. We find that clos…