Edward Rea
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View article: Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex
Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex Open
Mitosis in Plasmodium spp., the causative agent of malaria, is fundamentally different from model eukaryotes, proceeding via a bipartite microtubule organising centre (MTOC) and lacking canonical regulators such as Polo and Bub1 kinases. D…
View article: <i>Plasmodium</i> ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex
<i>Plasmodium</i> ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex Open
Mitosis in Plasmodium spp., the causative agent of malaria, is fundamentally different from model eukaryotes, proceeding via a bipartite microtubule organising centre (MTOC) and lacking canonical regulators such as Polo and Bub1 kinases. D…
View article: Quantitative photography for rapid, reliable measurement of marine macro‐plastic pollution
Quantitative photography for rapid, reliable measurement of marine macro‐plastic pollution Open
Plastics are now ubiquitous in the environment and have been studied in wildlife and in ecosystems for more than 50 years. Measurement of size, shape and colour data for individual fragments of plastic is labour‐intensive, unreliable and p…
View article: Discovery of essential kinetoplastid-insect adhesion proteins and their function in<i>Leishmania</i>-sand fly interactions
Discovery of essential kinetoplastid-insect adhesion proteins and their function in<i>Leishmania</i>-sand fly interactions Open
Leishmania species, members of the kinetoplastid parasites, cause leishmaniasis, a neglected tropical disease, in millions of people worldwide 1 . Leishmania has a complex life cycle with multiple developmental forms, as it cycles between …
View article: Formation and three-dimensional architecture of Leishmania adhesion in the sand fly vector
Formation and three-dimensional architecture of Leishmania adhesion in the sand fly vector Open
Attachment to a substrate to maintain position in a specific ecological niche is a common strategy across biology, especially for eukaryotic parasites. During development in the sand fly vector, the eukaryotic parasite Leishmania adheres t…
View article: Plasmodium ARK2-EB1 axis drives the unconventional spindle dynamics, scaffold formation and chromosome segregation of sexual transmission stages
Plasmodium ARK2-EB1 axis drives the unconventional spindle dynamics, scaffold formation and chromosome segregation of sexual transmission stages Open
Mechanisms of cell division are remarkably diverse, suggesting the underlying molecular networks among eukaryotes differ extensively. The Aurora family of kinases orchestrates the process of chromosome segregation and cytokinesis during ce…
View article: <i>Plasmodium</i>ARK2-EB1 axis drives the unconventional spindle dynamics, scaffold formation and chromosome segregation of sexual transmission stages
<i>Plasmodium</i>ARK2-EB1 axis drives the unconventional spindle dynamics, scaffold formation and chromosome segregation of sexual transmission stages Open
Mechanisms of cell division are remarkably diverse, suggesting the underlying molecular networks among eukaryotes differ extensively. The Aurora family of kinases orchestrates the process of chromosome segregation and cytokinesis during ce…
View article: Formation and three-dimensional architecture of <i>Leishmania</i> adhesion in the sand fly vector
Formation and three-dimensional architecture of <i>Leishmania</i> adhesion in the sand fly vector Open
Attachment to a substrate to maintain position in a specific ecological niche is a common strategy across biology, especially for eukaryotic parasites. During development in the sand fly vector, the eukaryotic parasite Leishmania adheres t…
View article: A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission
A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission Open
Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria-causing parasites have a life cycle with unique cell-division cycles, and a repertoire of divergent CD…
View article: A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission
A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission Open
Summary Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria-causing parasites have a life cycle with unique cell-division cycles, and a repertoire of dive…
View article: Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission
Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission Open
Kinesin-8 proteins are microtubule motors that are often involved in regulation of mitotic spindle length and chromosome alignment. They move towards the plus ends of spindle microtubules and regulate the dynamics of these ends due, at lea…
View article: Kinesin-8B controls basal body function and flagellum formation and is key to malaria transmission
Kinesin-8B controls basal body function and flagellum formation and is key to malaria transmission Open
Eukaryotic flagella are conserved microtubule-based organelles that drive cell motility. Plasmodium , the causative agent of malaria, has a single flagellate stage: the male gamete in the mosquito. Three rounds of endomitotic division in m…
View article: Systematic analysis of <i>Plasmodium</i> myosins reveals differential expression, localisation, and function in invasive and proliferative parasite stages
Systematic analysis of <i>Plasmodium</i> myosins reveals differential expression, localisation, and function in invasive and proliferative parasite stages Open
The myosin superfamily comprises of actin-dependent eukaryotic molecular motors important in a variety of cellular functions. Although well studied in many systems, knowledge of their functions in Plasmodium, the causative agent of malaria…
View article: Kinesin-8B controls basal body function and flagellum formation and is key to malaria parasite transmission
Kinesin-8B controls basal body function and flagellum formation and is key to malaria parasite transmission Open
Eukaryotic flagella are conserved microtubule-based organelles that drive cell motility. Plasmodium, the causative agent of malaria, has a single flagellate stage: the male gamete in the mosquito. Three rounds of endomitotic division toget…
View article: <i>Plasmodium</i> condensin core subunits (SMC2/SMC4) mediate atypical mitosis and are essential for parasite proliferation and transmission
<i>Plasmodium</i> condensin core subunits (SMC2/SMC4) mediate atypical mitosis and are essential for parasite proliferation and transmission Open
Summary Condensin is a multi-subunit protein complex regulating chromosome condensation and segregation during cell division. In Plasmodium spp., the causative agent of malaria, cell division is atypical and the role of condensin is unclea…
View article: Systematic analysis of <i>Plasmodium</i> myosins reveals differential expression, localization and function in invasive and proliferative parasite stages
Systematic analysis of <i>Plasmodium</i> myosins reveals differential expression, localization and function in invasive and proliferative parasite stages Open
Summary The myosin superfamily comprises of actin-dependent eukaryotic molecular motors important in a variety of cellular functions. Although well studied in many systems, knowledge of their functions in Plasmodium , the causative agent o…
View article: <i>Plasmodium</i> Kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission
<i>Plasmodium</i> Kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission Open
Kinesin-8 proteins are microtubule motors that are often involved in regulation of mitotic spindle length and chromosome alignment. They move towards the ends of spindle microtubules and regulate the dynamics of these ends due, at least in…
View article: <i>Plasmodium</i>centrin<i>Pb</i>CEN-4 localizes to the putative MTOC and is dispensable for malaria parasite proliferation
<i>Plasmodium</i>centrin<i>Pb</i>CEN-4 localizes to the putative MTOC and is dispensable for malaria parasite proliferation Open
Centrins are calmodulin-like phosphoproteins present in the centrosome and play an active role in the duplication, separation and organization of centrosomal structures such as the microtubule-organizing centre (MTOC) during mitosis. They …