Edward T. Moseley
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View article: Video Intervention and Goals-of-Care Documentation in Hospitalized Older Adults
Video Intervention and Goals-of-Care Documentation in Hospitalized Older Adults Open
Importance Despite the benefits of goals-of-care (GOC) communication, many hospitalized individuals never communicate their goals or preferences to clinicians. Objective To assess whether a GOC video intervention delivered by palliative ca…
View article: Study protocol for Video Images about Decisions to Improve Ethical Outcomes with Palliative Care Educators (VIDEO-PCE): a pragmatic stepped wedge cluster randomised trial of older patients admitted to the hospital
Study protocol for Video Images about Decisions to Improve Ethical Outcomes with Palliative Care Educators (VIDEO-PCE): a pragmatic stepped wedge cluster randomised trial of older patients admitted to the hospital Open
Introduction Despite the known benefit to patients and families, discussions about goals, values and preferences for medical care in advancing serious illness often do not occur. Many system and clinician factors, such as patient and clini…
View article: Associations Between Family Member Involvement and Outcomes of Patients Admitted to the Intensive Care Unit: Retrospective Cohort Study
Associations Between Family Member Involvement and Outcomes of Patients Admitted to the Intensive Care Unit: Retrospective Cohort Study Open
Background Little is known about family member involvement, by relationship status, for patients treated in the intensive care unit (ICU). Objective Using documentation of family interactions in clinical notes, we examined associations bet…
View article: Video Images about Decisions for Ethical Outcomes in Kidney Disease (VIDEO-KD): the study protocol for a multi-centre randomised controlled trial
Video Images about Decisions for Ethical Outcomes in Kidney Disease (VIDEO-KD): the study protocol for a multi-centre randomised controlled trial Open
Introduction Older patients with advanced chronic kidney disease (CKD) often are inadequately prepared to make informed decisions about treatments including dialysis and cardiopulmonary resuscitation. Further, evidence shows that patients …
View article: Association of an Advance Care Planning Video and Communication Intervention With Documentation of Advance Care Planning Among Older Adults
Association of an Advance Care Planning Video and Communication Intervention With Documentation of Advance Care Planning Among Older Adults Open
ClinicalTrials.gov Identifier: NCT04660422.
View article: Associations Between Family Member Involvement and Outcomes of Patients Admitted to the Intensive Care Unit: Retrospective Cohort Study (Preprint)
Associations Between Family Member Involvement and Outcomes of Patients Admitted to the Intensive Care Unit: Retrospective Cohort Study (Preprint) Open
BACKGROUND Little is known about family member involvement, by relationship status, for patients treated in the intensive care unit (ICU). OBJECTIVE Using documentation of family interactions in clinical notes, we examined associations …
View article: Deep learning to predict long-term mortality in patients requiring 7 days of mechanical ventilation
Deep learning to predict long-term mortality in patients requiring 7 days of mechanical ventilation Open
Background Among patients with acute respiratory failure requiring prolonged mechanical ventilation, tracheostomies are typically placed after approximately 7 to 10 days. Yet half of patients admitted to the intensive care unit receiving t…
View article: Mining heterogeneous clinical notes by multi-modal latent topic model
Mining heterogeneous clinical notes by multi-modal latent topic model Open
Latent knowledge can be extracted from the electronic notes that are recorded during patient encounters with the health system. Using these clinical notes to decipher a patient’s underlying comorbidites, symptom burdens, and treatment cour…
View article: Sustained maternal antibody and cellular immune responses in pregnant women infected with Zika virus and mother to infant transfer of Zika‐specific antibodies
Sustained maternal antibody and cellular immune responses in pregnant women infected with Zika virus and mother to infant transfer of Zika‐specific antibodies Open
Problem Evaluation of Zika virus (ZIKV)‐specific humoral and cellular immune response in pregnant women exposed to ZIKV. Method of Study In this observational, prospective cohort study, we recruited pregnant women presenting for prenatal u…
View article: A Corpus for Detecting High-Context Medical Conditions in Intensive Care Patient Notes Focusing on Frequently Readmitted Patients
A Corpus for Detecting High-Context Medical Conditions in Intensive Care Patient Notes Focusing on Frequently Readmitted Patients Open
A crucial step within secondary analysis of electronic health records (EHRs) is to identify the patient cohort under investigation. While EHRs contain medical billing codes that aim to represent the conditions and treatments patients may h…
View article: Clinical XLNet: Modeling Sequential Clinical Notes and Predicting Prolonged Mechanical Ventilation
Clinical XLNet: Modeling Sequential Clinical Notes and Predicting Prolonged Mechanical Ventilation Open
Clinical notes contain rich information, which is relatively unexploited in predictive modeling compared to structured data. In this work, we developed a new clinical text representation Clinical XLNet that leverages the temporal informati…
View article: Clinical XLNet: Modeling Sequential Clinical Notes and Predicting Prolonged Mechanical Ventilation
Clinical XLNet: Modeling Sequential Clinical Notes and Predicting Prolonged Mechanical Ventilation Open
Clinical notes contain rich data, which is unexploited in predictive modeling compared to structured data. In this work, we developed a new text representation Clinical XLNet for clinical notes which also leverages the temporal information…
View article: OP34 Finding what matters: using natural language processing to identify patient care preferences within clinical notes
OP34 Finding what matters: using natural language processing to identify patient care preferences within clinical notes Open
Background Delivering care that is consistent with patient preferences is considered the outcome of successful advance care planning interventions. However, patient preferences are often difficult to ascertain within clinical notes, and th…
View article: Lack of therapeutic efficacy of an antibody to α <sub>4</sub> β <sub>7</sub> in SIVmac251-infected rhesus macaques
Lack of therapeutic efficacy of an antibody to α <sub>4</sub> β <sub>7</sub> in SIVmac251-infected rhesus macaques Open
An antibody is not the antidote An HIV therapeutic that would give long-term remission without sustained antiretroviral therapy (ART) is a long-term goal. Byrareddy et al. [ Science 354 , 197 (2016)] reported that treating simian immunodef…
View article: Comparing deep learning and concept extraction based methods for patient phenotyping from clinical narratives
Comparing deep learning and concept extraction based methods for patient phenotyping from clinical narratives Open
In secondary analysis of electronic health records, a crucial task consists in correctly identifying the patient cohort under investigation. In many cases, the most valuable and relevant information for an accurate classification of medica…
View article: Comparing Rule-Based and Deep Learning Models for Patient Phenotyping
Comparing Rule-Based and Deep Learning Models for Patient Phenotyping Open
Objective: We investigate whether deep learning techniques for natural language processing (NLP) can be used efficiently for patient phenotyping. Patient phenotyping is a classification task for determining whether a patient has a medical …
View article: Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys
Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys Open
Zika virus (ZIKV) is responsible for a major ongoing epidemic in the Americas and has been causally associated with fetal microcephaly. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Her…
View article: Integrating Non-clinical Data with EHRs
Integrating Non-clinical Data with EHRs Open
Non-clinical factors make a significant contribution to an individual's health and providing this data to clinicians could inform context, counseling, and treatments.