Edward Topp
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View article: Food-borne microbes influence conjugative transfer of antimicrobial resistance plasmids in pre-disturbed gut microbiome
Food-borne microbes influence conjugative transfer of antimicrobial resistance plasmids in pre-disturbed gut microbiome Open
Ingestion of antibiotic-resistant bacteria following antibiotic treatments may lead to the transfer of antimicrobial resistance genes (ARGs) within a disturbed gut microbiota. However, it remains unclear whether and how microbes present in…
View article: Crossing the streams: improving data quality and integration across the One Health genomics continuum with data standards and implementation strategies
Crossing the streams: improving data quality and integration across the One Health genomics continuum with data standards and implementation strategies Open
The Canadian Genomics Research and Development Initiative for Antimicrobial Resistance (GRDI-AMR) uses a genomics-based approach to understand how health care, food production and the environment contribute to the development of antimicrob…
View article: Treatment of antibiotic-manufacturing wastewater enriches for <i>Aeromonas veronii</i>, a zoonotic antibiotic-resistant emerging pathogen
Treatment of antibiotic-manufacturing wastewater enriches for <i>Aeromonas veronii</i>, a zoonotic antibiotic-resistant emerging pathogen Open
Antibiotic-manufacturing wastewater treatment plants primarily target chemical pollutants, but their processes may select for antibiotic-resistant pathogens and antibiotic resistance genes. Leveraging the combined strengths of deep metagen…
View article: Genomic characterization of pathotype diversity and drug resistance among generic <i>Escherichia coli</i> isolated from broiler chickens in Canada
Genomic characterization of pathotype diversity and drug resistance among generic <i>Escherichia coli</i> isolated from broiler chickens in Canada Open
Escherichia coli is a Gram-negative bacterium that is ubiquitous in animals and humans, with some strains capable of causing disease. The aim of this study was to perform a comparative genomic analysis of 2732 generic E. coli isolates that…
View article: How Gut Microbiome Perturbation Caused by Antibiotic Pre-Treatments Affected the Conjugative Transfer of Antimicrobial Resistance Genes
How Gut Microbiome Perturbation Caused by Antibiotic Pre-Treatments Affected the Conjugative Transfer of Antimicrobial Resistance Genes Open
The global spread of antimicrobial resistance genes (ARGs) poses a significant threat to public health. While antibiotics effectively treat bacterial infections, they can also induce gut dysbiosis, the severity of which varies depending on…
View article: The broom of the system: a harmonized contextual data specification for One Health AMR pathogen genomic surveillance
The broom of the system: a harmonized contextual data specification for One Health AMR pathogen genomic surveillance Open
One Health genomics initiatives often involve data streams originating from different sources, institutions, sectors, and information management systems. These are often heterogeneous datasets structured in a variety of ways, posing challe…
View article: The broom of the system: a harmonized contextual data specification for One Health AMR pathogen genomic surveillance
The broom of the system: a harmonized contextual data specification for One Health AMR pathogen genomic surveillance Open
One Health genomics initiatives often involve data streams originating from different sources, institutions, sectors, and information management systems. These are often heterogeneous datasets structured in a variety of ways, posing challe…
View article: High-throughput single-cell sequencing of activated sludge microbiome
High-throughput single-cell sequencing of activated sludge microbiome Open
Wastewater treatment plants (WWTPs) represent one of biotechnology's largest and most critical applications, playing a pivotal role in environmental protection and public health. In WWTPs, activated sludge (AS) plays a major role in removi…
View article: Gut Microbiome Perturbation Affected Conjugative Transfer of Antimicrobial Resistance Genes
Gut Microbiome Perturbation Affected Conjugative Transfer of Antimicrobial Resistance Genes Open
The global spread of antimicrobial resistance genes (ARGs) poses a significant threat to public health. While antibiotics effectively treat bacterial infections, they can also induce gut dysbiosis, the severity of which varies depending on…
View article: Sustainable wastewater reuse for agriculture
Sustainable wastewater reuse for agriculture Open
View article: Complete genome sequence of <i>Bradyrhizobium ottawaense</i> strain MIAE 01942 isolated from soybean nodules grown in antibiotic-amended soil
Complete genome sequence of <i>Bradyrhizobium ottawaense</i> strain MIAE 01942 isolated from soybean nodules grown in antibiotic-amended soil Open
Bradyrhizobium ottawaense MIAE 01942 is a symbiotic nitrogen-fixing bacterium isolated from the root nodules of soybeans grown in agricultural soils amended with veterinary antibiotics. The genome consists of a single 8.45 Mb circular chro…
View article: Emerging contaminants: A One Health perspective
Emerging contaminants: A One Health perspective Open
Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary health. Despite global efforts to mitigate legacy pollutants, the continuous introduction of new substances remains a m…
View article: Dynamic effects of black soldier fly larvae meal on the cecal bacterial microbiota and prevalence of selected antimicrobial resistant determinants in broiler chickens
Dynamic effects of black soldier fly larvae meal on the cecal bacterial microbiota and prevalence of selected antimicrobial resistant determinants in broiler chickens Open
View article: Metagenomic Analysis Reveals the Transfer of Antibiotic Resistance from Manure-Fertilized Soil to Carrot Microbiome
Metagenomic Analysis Reveals the Transfer of Antibiotic Resistance from Manure-Fertilized Soil to Carrot Microbiome Open
Crops grown in manure-fertilized soil are more likely to be contaminated with antibiotic resistance genes (ARGs) than when grown in unmanured soil, and therefore more likely to represent a route of ARG exposure to consumers. Existing studi…
View article: Seeing the whole elephant: designing ‘one health’ governance to fight antimicrobial resistance
Seeing the whole elephant: designing ‘one health’ governance to fight antimicrobial resistance Open
View article: Metagenome meta-analysis reveals an increase in the abundance of some multidrug efflux pumps and mobile genetic elements in chemically polluted environments
Metagenome meta-analysis reveals an increase in the abundance of some multidrug efflux pumps and mobile genetic elements in chemically polluted environments Open
Many human activities contaminate terrestrial and aquatic environments with numerous chemical pollutants that not only directly alter the environment but also affect microbial communities in ways that are potentially concerning to human he…
View article: Characterization of Proteus mirabilis and associated plasmids isolated from anaerobic dairy cattle manure digesters
Characterization of Proteus mirabilis and associated plasmids isolated from anaerobic dairy cattle manure digesters Open
Proteus mirabilis is an opportunistic pathogen associated with a variety of human infections, including urinary tract infections. The prevalence of P . mirabilis in foods of animal origin and in the manure by-products created in animal pro…
View article: Toward a Universal Unit for Quantification of Antibiotic Resistance Genes in Environmental Samples
Toward a Universal Unit for Quantification of Antibiotic Resistance Genes in Environmental Samples Open
Surveillance of antibiotic resistance genes (ARGs) has been increasingly conducted in environmental sectors to complement the surveys in human and animal sectors under the "One-Health" framework. However, there are substantial challenges i…
View article: Effect of subtherapeutic and therapeutic sulfamethazine concentrations on transcribed genes and translated proteins involved in <i>Microbacterium</i> sp. C448 resistance and degradation
Effect of subtherapeutic and therapeutic sulfamethazine concentrations on transcribed genes and translated proteins involved in <i>Microbacterium</i> sp. C448 resistance and degradation Open
Microbacterium sp. C448, isolated from a soil regularly exposed to sulfamethazine (SMZ), can use various sulphonamide antibiotics as the sole carbon source for growth. The basis for the regulation of genes encoding the sulphonamide metabol…
View article: Modeling Antibiotic Concentrations in the Vicinity of Antibiotic-Producing Bacteria at the Micron Scale
Modeling Antibiotic Concentrations in the Vicinity of Antibiotic-Producing Bacteria at the Micron Scale Open
It is generally assumed that a natural function of antibiotics is to provide their producers with a competitive advantage. If this were the case, sensitive organisms in proximity to producers would be exposed to inhibitory concentrations.
View article: Potential selection and maintenance of manure-originated multi-drug resistant plasmids at sub-clinical antibiotic concentrations
Potential selection and maintenance of manure-originated multi-drug resistant plasmids at sub-clinical antibiotic concentrations Open
The goal of this study was to determine minimum selection concentrations of various antibiotics using four manure-originated multi-drug resistant plasmids in a surrogate Escherichia coli host. These plasmids carried genes conferring resist…
View article: Genetic characterization of extended-β-lactamase (ESBL) plasmids captured from dairy manures
Genetic characterization of extended-β-lactamase (ESBL) plasmids captured from dairy manures Open
This study was to assess the gene diversity and characterize a large set of plasmids harboring extended β-lactamase (ESBL) genes from raw and digested dairy manure. A total of eighty-four plasmids that were captured in this E. coli recipie…
View article: Comparative Genomic Analysis of Enterococci across Sectors of the One Health Continuum
Comparative Genomic Analysis of Enterococci across Sectors of the One Health Continuum Open
Enterococci are Gram-positive bacteria that can be isolated from a variety of environments including soil, water, plants, and the intestinal tract of humans and animals. Although they are considered commensals in humans, Enterococcus spp. …
View article: Characterization of Escherichia coli and Other Enterobacterales Resistant to Extended-Spectrum Cephalosporins Isolated from Dairy Manure in Ontario, Canada
Characterization of Escherichia coli and Other Enterobacterales Resistant to Extended-Spectrum Cephalosporins Isolated from Dairy Manure in Ontario, Canada Open
The increase in antimicrobial resistance is of concern for human and animal health, especially when resistance is conferred to extended-spectrum cephalosporins, which are used to treat serious infections in both human and veterinary medici…
View article: Effects of partial or complete replacement of soybean meal with commercial black soldier fly larvae (Hermetia illucens) meal on growth performance, cecal short chain fatty acids, and excreta metabolome of broiler chickens
Effects of partial or complete replacement of soybean meal with commercial black soldier fly larvae (Hermetia illucens) meal on growth performance, cecal short chain fatty acids, and excreta metabolome of broiler chickens Open
Black soldier fly larvae meal (BSFLM) is receiving great attention as a rich source of protein and antimicrobials for poultry. Therefore, we evaluated the effects of partially or completely replacing soybean meal (SBM) with commercial BSFL…
View article: Persistence and Evidence for Accelerated Biodegradation of Streptomycin in Agricultural Soils
Persistence and Evidence for Accelerated Biodegradation of Streptomycin in Agricultural Soils Open
View article: The Complex Interplay Between Antibiotic Resistance and Pharmaceutical and Personal Care Products in the Environment
The Complex Interplay Between Antibiotic Resistance and Pharmaceutical and Personal Care Products in the Environment Open
Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are important environmental contaminants. Nonetheless, what drives the evolution, spread, and transmission of antibiotic resistance dissemination is still poorly un…
View article: Production systems and important antimicrobial resistant-pathogenic bacteria in poultry: a review
Production systems and important antimicrobial resistant-pathogenic bacteria in poultry: a review Open
View article: Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg Open
Antimicrobial resistance (AMR) has become a critical threat to public health worldwide. The use of antimicrobials in food and livestock agriculture, including the production of poultry, is thought to contribute to the dissemination of anti…
View article: Validation of a method to determine transformation of chemicals in anaerobic liquid pig and cattle manure for the OECD test guideline programme
Validation of a method to determine transformation of chemicals in anaerobic liquid pig and cattle manure for the OECD test guideline programme Open
Manure is widely used as a fertilizer and applied to agricultural land. It may contain highly active chemicals like veterinary medicinal products or biocides, which enter into the environment by this pathway. This is recognized by several …