Edward Trybala
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View article: Bioactive 2-arylbenzofuran and chalcone derivatives from Morus mesozygia Stapf
Bioactive 2-arylbenzofuran and chalcone derivatives from Morus mesozygia Stapf Open
The phytochemical investigation of the stem bark of Morus mesozygia afforded the fourteen known secondary metabolites moracin N (1), moracin S (2), mulberrofuran L (3), moracin C (4), moracin L (5), moracin M (6), moracin D (7), artopithec…
View article: Ethnopharmacological survey of Rwandese medicinal plants used for respiratory infections. Effect of Senecio maranguensis extract against respiratory syncytial virus
Ethnopharmacological survey of Rwandese medicinal plants used for respiratory infections. Effect of Senecio maranguensis extract against respiratory syncytial virus Open
View article: Remdesivir is active <i>in vitro</i> against tick-borne encephalitis virus and selects for resistance mutations in the viral RNA-dependent RNA polymerase
Remdesivir is active <i>in vitro</i> against tick-borne encephalitis virus and selects for resistance mutations in the viral RNA-dependent RNA polymerase Open
RDV exhibits potent in vitro antiviral activity against TBEV via specific targeting of the viral RdRp as confirmed by the emergence of resistance-associated double NS5 substitutions in vitro in the presence of RDV. While the …
View article: Bioactive abietenolide diterpenes from Suregada procera
Bioactive abietenolide diterpenes from Suregada procera Open
The phytochemical investigation of the leaves and the roots of Suregada procera afforded the new ent-abietane diterpenoid sureproceriolide A (1) along with the known secondary metabolites 8,14β:11,12α-diepoxy-13(15)-abietane-16,12-olid (2)…
View article: Antiviral Rotenoids and Isoflavones Isolated from<i>Millettia</i><i>oblata</i>ssp.<i>teitensis</i>
Antiviral Rotenoids and Isoflavones Isolated from<i>Millettia</i><i>oblata</i>ssp.<i>teitensis</i> Open
Three new (1-3) and six known rotenoids (5-10), along with three known isoflavones (11-13), were isolated from the leaves of Millettia oblata ssp. teitensis. A new glycosylated isofla…
View article: Identification of epidermal growth factor receptor-tyrosine kinase inhibitor targeting the VP1 pocket of human rhinovirus
Identification of epidermal growth factor receptor-tyrosine kinase inhibitor targeting the VP1 pocket of human rhinovirus Open
Screening a library of 1,200 preselected kinase inhibitors for anti-human rhinovirus 2 (HRV-2) activity in HeLa cells identified a class of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) as effective virus blockers.…
View article: Ethnopharmacological Survey-Based Screening of Rwandese Medicinal Plants for Anti-Respiratory Syncytial Virus Activity with Extended Studies of Methanolic Extract of Senecio Maranguensis O. Hoffm. Leaves
Ethnopharmacological Survey-Based Screening of Rwandese Medicinal Plants for Anti-Respiratory Syncytial Virus Activity with Extended Studies of Methanolic Extract of Senecio Maranguensis O. Hoffm. Leaves Open
View article: Structure and Role of O-Linked Glycans in Viral Envelope Proteins
Structure and Role of O-Linked Glycans in Viral Envelope Proteins Open
N- and O-glycans are both important constituents of viral envelope glycoproteins. O-linked glycosylation can be initiated by any of 20 different human polypeptide O-acetylgalactosaminyl transferases, resulting in an important functional O-…
View article: Crotofolane Diterpenoids and Other Constituents Isolated from <i>Croton kilwae</i>
Crotofolane Diterpenoids and Other Constituents Isolated from <i>Croton kilwae</i> Open
Six new crotofolane diterpenoids (1-6) and 13 known compounds (7-19) were isolated from the MeOH-CH2Cl2 (1:1, v/v) extracts of the leaves and stem bark of Croton kilwae. The structur…
View article: Modified <i>ent</i>-Abietane Diterpenoids from the Leaves of <i>Suregada zanzibariensis</i>
Modified <i>ent</i>-Abietane Diterpenoids from the Leaves of <i>Suregada zanzibariensis</i> Open
The leaf extract of Suregada zanzibariensis gave two new modified ent-abietane diterpenoids, zanzibariolides A (1) and B (2), and two known triterpenoids, simiarenol (3) and β-amyrin (4). The struc…
View article: Cellular Chondroitin Sulfate and the Mucin-like Domain of Viral Glycoprotein C Promote Diffusion of Herpes Simplex Virus 1 While Heparan Sulfate Restricts Mobility
Cellular Chondroitin Sulfate and the Mucin-like Domain of Viral Glycoprotein C Promote Diffusion of Herpes Simplex Virus 1 While Heparan Sulfate Restricts Mobility Open
The diffusion of viruses at the cell membrane is essential to reach a suitable entry site and initiate subsequent internalization. Although many viruses take advantage of glycosaminoglycans (GAG) to bind to the cell surface, little is know…
View article: Crotofolane Diterpenoids from Croton kilwae
Crotofolane Diterpenoids from Croton kilwae Open
NMR raw data, NMReDATA, X-ray data
View article: Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction
Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction Open
Heparan sulfate (HS) is a cell surface polysaccharide recently identified as a coreceptor with the ACE2 protein for the S1 spike protein on SARS-CoV-2 virus, providing a tractable new therapeutic target. Clinically used heparins demonstrat…
View article: Anti-respiratory syncytial virus and anti-herpes simplex virus activity of six Tanzanian medicinal plants with extended studies of Erythrina abyssinica stem bark
Anti-respiratory syncytial virus and anti-herpes simplex virus activity of six Tanzanian medicinal plants with extended studies of Erythrina abyssinica stem bark Open
Altogether, the water extract of six medicinal plants showed anti-RSV and anti-HSV-2 activities. Extended studies of the stem bark of E. abyssinica identified antiviral components that potently and selectively inhibited infectivity of free…
View article: Abietane and Ent-abietane Diterpenoids from the Leaves of Suregada Zanzibariensis
Abietane and Ent-abietane Diterpenoids from the Leaves of Suregada Zanzibariensis Open
NMR raw data (FIDs), processed mestrenova files and NMReDATA files for the isolated compounds.
View article: Herpes Simplex Virus 1 and 2 Infections during Differentiation of Human Cortical Neurons
Herpes Simplex Virus 1 and 2 Infections during Differentiation of Human Cortical Neurons Open
Herpes simplex virus 1 (HSV-1) and 2 (HSV-2) can infect the central nervous system (CNS) with dire consequences; in children and adults, HSV-1 may cause focal encephalitis, while HSV-2 causes meningitis. In neonates, both viruses can cause…
View article: Antiviral iridoid glycosides from Clerodendrum myricoides
Antiviral iridoid glycosides from Clerodendrum myricoides Open
View article: Herpes Simplex Virus Type 2 Mucin-Like Glycoprotein mgG Promotes Virus Release from the Surface of Infected Cells
Herpes Simplex Virus Type 2 Mucin-Like Glycoprotein mgG Promotes Virus Release from the Surface of Infected Cells Open
The contribution of virus components to liberation of herpes simplex virus type 2 (HSV-2) progeny virions from the surface of infected cells is poorly understood. We report that the HSV-2 mutant deficient in the expression of a mucin-like …
View article: Antiviral Iridoid Glycosides from Clerodendrum myricoides
Antiviral Iridoid Glycosides from Clerodendrum myricoides Open
NMR data (FID, mnova) and NMReDATA
View article: Antiviral Iridoid Glycosides from Clerodendrum myricoides
Antiviral Iridoid Glycosides from Clerodendrum myricoides Open
NMR data (FID, mnova) and NMReDATA
View article: Surveillance of wastewater revealed peaks of SARS-CoV-2 preceding those of hospitalized patients with COVID-19
Surveillance of wastewater revealed peaks of SARS-CoV-2 preceding those of hospitalized patients with COVID-19 Open
View article: Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 By Disrupting The Spike-ACE2 interaction
Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 By Disrupting The Spike-ACE2 interaction Open
Summary Heparan sulfate (HS) is a cell surface polysaccharide recently identified as a co-receptor with the ACE2 protein for recognition of the S1 spike protein on SARS-CoV-2 virus, providing a tractable new target for therapeutic interven…
View article: Regulatory Mechanisms of the Mucin-Like Region on Herpes Simplex Virus during Cellular Attachment
Regulatory Mechanisms of the Mucin-Like Region on Herpes Simplex Virus during Cellular Attachment Open
Mucin-like regions, characterized by a local high density of O-linked glycosylation, are found on the viral envelope glycoproteins of many viruses. Herpes simplex virus type 1 (HSV-1), for example, exhibits a mucin-like region on its glyco…
View article: Binding Kinetics and Lateral Mobility of HSV-1 on End-Grafted Sulfated Glycosaminoglycans
Binding Kinetics and Lateral Mobility of HSV-1 on End-Grafted Sulfated Glycosaminoglycans Open
View article: The Cholestanol-Conjugated Sulfated Oligosaccharide PG545 Disrupts the Lipid Envelope of Herpes Simplex Virus Particles
The Cholestanol-Conjugated Sulfated Oligosaccharide PG545 Disrupts the Lipid Envelope of Herpes Simplex Virus Particles Open
Herpes simplex virus (HSV) and many other viruses, including HIV, initiate infection of host cells by binding to glycosaminoglycan (GAG) chains of cell surface proteoglycans. Although GAG mimetics, such as sulfated oligo- and polysaccharid…
View article: Mucin-like Region of Herpes Simplex Virus Type 1 Attachment Protein Glycoprotein C (gC) Modulates the Virus-Glycosaminoglycan Interaction
Mucin-like Region of Herpes Simplex Virus Type 1 Attachment Protein Glycoprotein C (gC) Modulates the Virus-Glycosaminoglycan Interaction Open