Edward W. Gregg
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View article: Age at type 2 diabetes diagnosis and risk of cancer: Cohort study in over 1 million individuals from the TriNetX US Collaborative Network
Age at type 2 diabetes diagnosis and risk of cancer: Cohort study in over 1 million individuals from the TriNetX US Collaborative Network Open
The five-year risk of cancer was higher in those with newly diagnosed type 2 diabetes versus those without. Absolute risk was greater in middle-older age adults, although relative rates were greater amongst younger adults. This persisted a…
View article: Regression from prediabetes to normoglycaemia and the role of cardiometabolic risk factors on the subsequent risk of developing type 2 diabetes
Regression from prediabetes to normoglycaemia and the role of cardiometabolic risk factors on the subsequent risk of developing type 2 diabetes Open
Aims/hypothesis We aimed to investigate the association between reversion to normoglycaemia among individuals with prediabetes (fasting plasma glucose 5.6–6.9 mmol/l in the absence of other criteria for type 2 diabetes) and the subsequent …
View article: Association between the English National Health Service Diabetes Prevention Programme and incident multiple long-term conditions
Association between the English National Health Service Diabetes Prevention Programme and incident multiple long-term conditions Open
Existing evaluations of the National Health Service Diabetes Prevention Programme (NHS DPP) in England have demonstrated associated reductions in body weight, hemoglobin A1c and incident type 2 diabetes (T2D). In this study, we examined as…
View article: Associations between Multimorbidity Clusters and All-Cause Mortality, Quality of Life and Physical Function: A Systematic Review Protocol
Associations between Multimorbidity Clusters and All-Cause Mortality, Quality of Life and Physical Function: A Systematic Review Protocol Open
Background Multimorbidity, defined as the coexistence of two or more chronic health conditions in affected individuals, is recognised as a significant global public health concern.. While previous research has identified common multimorbid…
View article: Trends in mortality and hospitalisations for cardiovascular, kidney and liver disease in people with type 2 diabetes in England, 2009–2019
Trends in mortality and hospitalisations for cardiovascular, kidney and liver disease in people with type 2 diabetes in England, 2009–2019 Open
Aims To assess longitudinal trends in total and cause‐specific mortality rates and in hospitalisation rates for diabetes complications among people with type 2 diabetes in England between 2009 and 2019; and to assess how trends differ by p…
View article: Prediabetes transitions to normoglycaemia or type 2 diabetes and associated risk factors in the Obesity, Diabetes and Cardiovascular Disease Collaboration: an individual-level pooled analysis of 19 prospective cohort studies
Prediabetes transitions to normoglycaemia or type 2 diabetes and associated risk factors in the Obesity, Diabetes and Cardiovascular Disease Collaboration: an individual-level pooled analysis of 19 prospective cohort studies Open
Deakin University Postgraduate Research Scholarship.
View article: Development of a Quality Improvement and Patient Safety Research Conceptual Framework to Inform Research Priorities for the Irish Healthcare System: Protocol for a Scoping Review
Development of a Quality Improvement and Patient Safety Research Conceptual Framework to Inform Research Priorities for the Irish Healthcare System: Protocol for a Scoping Review Open
Background A core part of the remit of the Evidence Based QUality Improvement and Patient Safety (EQUIPS) Research Network (2024–2029) is to inform research priorities for the Irish healthcare system. Previously, research prioritisation e…
View article: Socioeconomic disparities in diabetes prevalence among the population in Ireland
Socioeconomic disparities in diabetes prevalence among the population in Ireland Open
View article: Worldwide trends in diabetes prevalence: the NCD-RisC study – Authors' reply
Worldwide trends in diabetes prevalence: the NCD-RisC study – Authors' reply Open
View article: Bariatric and metabolic surgery medical tourism: the compelling need for regulation through transnational collaboration
Bariatric and metabolic surgery medical tourism: the compelling need for regulation through transnational collaboration Open
View article: World health Organization’s guidance for tracking non-communicable diseases towards sustainable development goals 3.4: an initiative for facility-based monitoring
World health Organization’s guidance for tracking non-communicable diseases towards sustainable development goals 3.4: an initiative for facility-based monitoring Open
This study was funded internally by WHO.
View article: Association of low-calorie sweetened product consumption and intakes of free sugar and ultra-processed foods in UK children: a national study from 2008 to 2019
Association of low-calorie sweetened product consumption and intakes of free sugar and ultra-processed foods in UK children: a national study from 2008 to 2019 Open
Purpose Little is known about the association between low- and no-calorie sweetened (LCS) product consumption and children’s dietary quality, despite the promotion of these products as sugar alternatives. This study examines the trends and…
View article: Risk factors for development of diabetic foot ulcer disease in two large contemporary <scp>UK</scp> cohorts
Risk factors for development of diabetic foot ulcer disease in two large contemporary <span>UK</span> cohorts Open
Aims Diabetic foot ulcer disease ( DFUD ) is common, life‐changing and associated with a lower 5‐Year survival rate than many cancers. However, the risk factors for DFUD have generally been identified in small, single‐centre, clinic‐based …
View article: Correction: Trends in lifetime risk and years of potential life lost from diabetes in the United States, 1997–2018
Correction: Trends in lifetime risk and years of potential life lost from diabetes in the United States, 1997–2018 Open
[This corrects the article DOI: 10.1371/journal.pone.0268805.].
View article: Childhood Obesity as a Predictor of Adult Physical/Functional Mobility; a Protocol for Systematic Review and Meta-Analysis.
Childhood Obesity as a Predictor of Adult Physical/Functional Mobility; a Protocol for Systematic Review and Meta-Analysis. Open
Background Childhood and adolescent obesity is a global public health concern. Systematic reviews have linked it to short-term complications 1 during childhood and various long-term health issues in adulthood, including cardiovascular dis…
View article: Disruption to diabetes and hypertension care during the COVID-19 pandemic in Latin America and the Caribbean and mitigation approaches: a scoping review
Disruption to diabetes and hypertension care during the COVID-19 pandemic in Latin America and the Caribbean and mitigation approaches: a scoping review Open
Background The COVID-19 pandemic disrupted care for non-communicable diseases globally. This study synthesizes evidence on disruptions to primary care, focusing on hypertension and diabetes care and mitigation approaches taken during the p…
View article: Obesity‐related glomerulopathy: How it happens and future perspectives
Obesity‐related glomerulopathy: How it happens and future perspectives Open
Obesity‐related glomerulopathy (ORG) is an emerging complication of excess adiposity. Its incidence rises alongside the obesity pandemic. Up to 40% of individuals can be affected by ORG, irrespective of the status of glomerular filtration …
View article: A multifactorial intervention to improve cardiovascular outcomes in adults with type 2 diabetes and current or previous diabetic foot ulcer disease: Protocol for a multi‐centre randomised control trial ( <scp>MiFoot</scp> study)
A multifactorial intervention to improve cardiovascular outcomes in adults with type 2 diabetes and current or previous diabetic foot ulcer disease: Protocol for a multi‐centre randomised control trial ( <span>MiFoot</span> study) Open
Background In the United Kingdom, the prevalence of diabetes‐related foot ulcer disease (DFUD) is 6.3%, and cardiovascular disease (CVD) is the leading cause of mortality in people with DFUD. This study aims to evaluate the effectiveness o…
View article: Development and validation of patient-level Chinese Diabetes Outcome Model (CDOM) on long-term complications in type 2 diabetes – an application of the Hong Kong Diabetes Register (HKDR)
Development and validation of patient-level Chinese Diabetes Outcome Model (CDOM) on long-term complications in type 2 diabetes – an application of the Hong Kong Diabetes Register (HKDR) Open
ObjectivePatient-level simulation models, mainly developed in Western populations, capture complex interactions between risk factors and complications to predict the long-term effectiveness and cost-effectiveness of novel tre…
View article: Multiple long-term conditions as the next transition in the global diabetes epidemic
Multiple long-term conditions as the next transition in the global diabetes epidemic Open
Several transitions, or new patterns and dynamics in the contributors and health outcomes, have altered the character and burden of the multi-decade, worldwide growth in prevalence of type 2 diabetes (T2DM). These changes have led to diffe…
View article: Global monitoring of hyperglycaemic emergencies in adults with diabetes: protocol for a systematic review of incidence and outcomes (2015–2024)
Global monitoring of hyperglycaemic emergencies in adults with diabetes: protocol for a systematic review of incidence and outcomes (2015–2024) Open
Background Hyperglycaemic emergencies, such as diabetic ketoacidosis (DKA) and hyperosmolar hyperglycaemic state (HHS), are critical indicators of inadequate glucose management, and highlight issues such as lack of insulin availability, su…
View article: The status of care for youth with type 1 diabetes within and coming from humanitarian crises settings: a narrative review
The status of care for youth with type 1 diabetes within and coming from humanitarian crises settings: a narrative review Open
Findings expose the dearth of data relating to defined youth with T1D within and coming from HCS, leaving the status of this population largely uncharacterised. With limited data indicating suboptimal T1D management, there is a pressing ne…
View article: Attainment of Global Diabetes Targets in 2021: A Pooled Analysis of Individual-Level Data from National Surveys in 100 Low-, Middle-, and High-Income Countries
Attainment of Global Diabetes Targets in 2021: A Pooled Analysis of Individual-Level Data from National Surveys in 100 Low-, Middle-, and High-Income Countries Open
View article: Evaluating the Effectiveness of REWIND (Reducing Weight with Intensive Dietary Support) on Type 2 Diabetes Remission
Evaluating the Effectiveness of REWIND (Reducing Weight with Intensive Dietary Support) on Type 2 Diabetes Remission Open
View article: Prediabetes Remission and Cardiovascular Morbidity and Mortality: A Post-Hoc Analysis from Dppos and Daqingdpos
Prediabetes Remission and Cardiovascular Morbidity and Mortality: A Post-Hoc Analysis from Dppos and Daqingdpos Open
View article: Trends in the incidence of young-adult-onset diabetes by diabetes type: a multi-national population-based study from an international diabetes consortium
Trends in the incidence of young-adult-onset diabetes by diabetes type: a multi-national population-based study from an international diabetes consortium Open
View article: Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants
Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants Open
View article: Consumption of low-calorie sweetened products and intakes of free sugar and energy among UK adults
Consumption of low-calorie sweetened products and intakes of free sugar and energy among UK adults Open
Background Policies to reduce free sugar intake in the population often suggest alternative low or no sugar products that may contain low-calorie sweeteners (LCS). However, the health effects of LCS are controversial and little is known ab…
View article: Traumatic brain injury (TBI) and mortality in older adults with and without pre-injury dementia
Traumatic brain injury (TBI) and mortality in older adults with and without pre-injury dementia Open
Importance Incidence of traumatic brain injury (TBI) is rising in older adults. Dementia is a common comorbidity amongst older adults and may worsen post-TBI outcomes, but this has not been systematically studied. Objective To compare all-…
View article: Trends in hospitalization for cardio‐renal disease and mortality in people with type 1 diabetes in England, 2009–2019
Trends in hospitalization for cardio‐renal disease and mortality in people with type 1 diabetes in England, 2009–2019 Open
Aim To assess mortality and complication trends in people with type 1 diabetes during the 11 years before the SARS‐CoV2 pandemic (2009–2019). Materials and Methods Sequential cohorts of people in England with type 1 diabetes aged ≥20 years…