Edward Winter
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View article: The MAPK homolog, Smk1, promotes assembly of the glucan layer of the spore wall in <i>S. cerevisiae</i>
The MAPK homolog, Smk1, promotes assembly of the glucan layer of the spore wall in <i>S. cerevisiae</i> Open
Smk1 is a MAPK homolog in the yeast Saccharomyces cerevisiae that controls the postmeiotic program of spore wall assembly. During this program, haploid cells are surrounded by a layer of mannan and then a layer of glucan. These inner layer…
View article: Isc10, an inhibitor of the Smk1 MAPK, prevents activation loop autophosphorylation and substrate phosphorylation through separate mechanisms
Isc10, an inhibitor of the Smk1 MAPK, prevents activation loop autophosphorylation and substrate phosphorylation through separate mechanisms Open
Many eukaryotic protein kinases are activated by the intramolecular autophosphorylation of activation loop residues. Smk1 is a meiosis-specific mitogen-activated protein kinase (MAPK) in yeast that autophosphorylates its activation loop ty…
View article: Isc10, an Inhibitor That Links the Anaphase-Promoting Complex to a Meiosis-Specific Mitogen-Activated Protein Kinase
Isc10, an Inhibitor That Links the Anaphase-Promoting Complex to a Meiosis-Specific Mitogen-Activated Protein Kinase Open
Smk1 is a meiosis-specific mitogen-activated protein kinase (MAPK) in yeast that controls spore differentiation. It is activated by a MAPK binding protein, Ssp2, upon completion of the meiotic divisions. The activation of Smk1 by Ssp2 is p…
View article: Considerations for the Scientific Support Process and Applications to Case Studies
Considerations for the Scientific Support Process and Applications to Case Studies Open
Case studies are vehicles to bridge the gap between science and practice because they provide opportunities to blend observations and interventions that have taken place in real-world environments with scientific rigor. The purpose of this…
View article: Can we trust “Magnitude-based inference”?
Can we trust “Magnitude-based inference”? Open
Since the times and works of William Sealy Gosset (1876-1937) and Ronald Aylmer Fisher (1890-1962), imperfections of conventional null-hypothesis significance testing and in particular, use of P-values to evaluate such testing (invariably …
View article: The meiosis-specific Cdc20 family-member Ama1 promotes binding of the Ssp2 activator to the Smk1 MAP kinase
The meiosis-specific Cdc20 family-member Ama1 promotes binding of the Ssp2 activator to the Smk1 MAP kinase Open
Smk1 is a meiosis-specific MAP kinase (MAPK) in budding yeast that is required for spore formation. It is localized to prospore membranes (PSMs), the structures that engulf haploid cells during meiosis II (MII). Similar to canonically acti…
View article: Ssp2 Binding Activates the Smk1 Mitogen-Activated Protein Kinase
Ssp2 Binding Activates the Smk1 Mitogen-Activated Protein Kinase Open
Smk1 is a meiosis-specific mitogen-activated protein kinase (MAPK) in Saccharomyces cerevisiae that couples spore morphogenesis to the completion of chromosome segregation. Similar to other MAPKs, Smk1 is controlled by phosphorylation of a…
View article: Misuse of “Power” and Other Mechanical Terms in Sport and Exercise Science Research
Misuse of “Power” and Other Mechanical Terms in Sport and Exercise Science Research Open
Despite the Système International d'Unitès (SI) that was published in 1960, there continues to be widespread misuse of the terms and nomenclature of mechanics in descriptions of exercise performance. Misuse applies principally to failure t…
View article: Autophosphorylation of the Smk1 MAPK is spatially and temporally regulated by Ssp2 during meiotic development in yeast
Autophosphorylation of the Smk1 MAPK is spatially and temporally regulated by Ssp2 during meiotic development in yeast Open
Smk1 is a meiosis-specific MAPK that controls spore wall morphogenesis in Saccharomyces cerevisiae. Although Smk1 is activated by phosphorylation of the threonine (T) and tyrosine (Y) in its activation loop, it is not phosphorylated by a d…
View article: Effects of an acute bout of aerobic exercise on immediate and subsequent three-day food intake and energy expenditure in active and inactive pre-menopausal women taking oral contraceptives
Effects of an acute bout of aerobic exercise on immediate and subsequent three-day food intake and energy expenditure in active and inactive pre-menopausal women taking oral contraceptives Open
2019 ± 746 kJ vs. 2710 ± 712 kJ; p <0.001, d = -1.00) at the ad libitum lunch. There were no significant differences in energy intake over the four days in active participants and there was a suppression of energy intake on the first day a…