Edwin Leeansyah
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View article: Restoration of MAIT cell function in healthcare-associated bacterial infections supports recovery of carbapenem efficacy against resistant bacteria
Restoration of MAIT cell function in healthcare-associated bacterial infections supports recovery of carbapenem efficacy against resistant bacteria Open
Antimicrobial resistance (AMR) presents a major clinical challenge to patients with healthcare-associated infections (HAIs), particularly among immunocompromised individuals and patients with comoribidites, who often exhibit an impaired mu…
View article: MAIT cell homing in intestinal homeostasis and inflammation
MAIT cell homing in intestinal homeostasis and inflammation Open
Mucosa-associated invariant T (MAIT) cells are a large population of unconventional T cells widely distributed in the human gastrointestinal tract. Their homing to the gut is central to maintaining mucosal homeostasis and immunity. This re…
View article: MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles
MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles Open
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that recognize microbial riboflavin pathway metabolites presented by evolutionarily conserved MR1 molecules. We explored the human MAIT cell compartment across organ do…
View article: MAIT cell activation and recruitment in inflammation and tissue damage in acute appendicitis
MAIT cell activation and recruitment in inflammation and tissue damage in acute appendicitis Open
Mucosal-associated invariant T (MAIT) cells are antimicrobial T cells abundant in the gut, but mechanisms for their migration into tissues during inflammation are poorly understood. Here, we used acute pediatric appendicitis (APA), a model…
View article: The Emerging Role of MAIT Cell Responses in Viral Infections
The Emerging Role of MAIT Cell Responses in Viral Infections Open
Mucosal-associated invariant T (MAIT) cells are unconventional T cells with innate-like antimicrobial responsiveness. MAIT cells are known for MR1 (MHC class I–related protein 1)-restricted recognition of microbial riboflavin metabolites g…
View article: Role of MAIT cells in gastrointestinal tract bacterial infections in humans: More than a gut feeling
Role of MAIT cells in gastrointestinal tract bacterial infections in humans: More than a gut feeling Open
Mucosa-associated invariant T (MAIT) cells are the largest population of unconventional T cells in humans. These antimicrobial T cells are poised with rapid effector responses following recognition of the cognate riboflavin (vitamin B2)-li…
View article: MAIT cells in chronic HBV infection‐related liver fibrosis: Friends or foes?
MAIT cells in chronic HBV infection‐related liver fibrosis: Friends or foes? Open
Hepatitis B (HBV) infection is a major worldwide public health problem. To date, no effective therapies have been successfully developed to completely eradicate HBV covalently closed circular DNA (cccDNA) and thus truly cure chronic HBV in…
View article: Angiotensin-Converting Enzyme 2-Based Biosensing Modalities and Devices for Coronavirus Detection
Angiotensin-Converting Enzyme 2-Based Biosensing Modalities and Devices for Coronavirus Detection Open
Rapid and cost-effective diagnostic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are a critical and valuable weapon for the coronavirus disease 2019 (COVID-19) pandemic response. SARS-CoV-2 invasion is primarily m…
View article: IL7RA single nucleotide polymorphisms are associated with the size and function of the MAIT cell population in treated HIV-1 infection
IL7RA single nucleotide polymorphisms are associated with the size and function of the MAIT cell population in treated HIV-1 infection Open
MAIT cells are persistently depleted and functionally exhausted in HIV-1-infected patients despite long-term combination antiretroviral therapy (cART). IL-7 treatment supports MAIT cell reconstitution in vivo HIV-1-infected individuals and…
View article: Mucosa-Associated Invariant T Cell Hypersensitivity to <i>Staphylococcus aureus</i> Leukocidin ED and Its Modulation by Activation
Mucosa-Associated Invariant T Cell Hypersensitivity to <i>Staphylococcus aureus</i> Leukocidin ED and Its Modulation by Activation Open
Mucosa-associated invariant T (MAIT) cells recognize bacterial riboflavin metabolite Ags presented by MHC class Ib–related protein (MR1) and play important roles in immune control of microbes that synthesize riboflavin. This includes the p…
View article: Exploring the Role of Innate Lymphocytes in the Immune System of Bats and Virus-Host Interactions
Exploring the Role of Innate Lymphocytes in the Immune System of Bats and Virus-Host Interactions Open
Bats are reservoirs of a large number of viruses of global public health significance, including the ancestral virus for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the causative agent of coronavirus disease 2019 (COVI…
View article: Hypersensitivity of MAIT cells to Leukocidin ED indicates a <i>Staphylococcus aureus</i> immune evasion mechanism targeting the innate effector cell response
Hypersensitivity of MAIT cells to Leukocidin ED indicates a <i>Staphylococcus aureus</i> immune evasion mechanism targeting the innate effector cell response Open
Mucosa-associated invariant T (MAIT) cells recognize bacterial riboflavin metabolite antigens presented by MR1 and play an important role in antimicrobial immune defense. Staphylococcus aureus is a pathobiont expressing a range of virulenc…
View article: Culture, expansion, and flow-cytometry-based functional analysis of pteropid bat MR1-restricted unconventional T cells
Culture, expansion, and flow-cytometry-based functional analysis of pteropid bat MR1-restricted unconventional T cells Open
Bats harbor viruses of global public health significance. Understanding bat immune systems may provide intervention strategies to prevent zoonotic disease transmission and identify therapeutic targets. This protocol describes how to cultur…
View article: MAIT cell activation is associated with disease severity markers in acute hantavirus infection
MAIT cell activation is associated with disease severity markers in acute hantavirus infection Open
Hantaviruses are zoonotic RNA viruses that cause severe acute disease in humans. Infected individuals have strong inflammatory responses that likely cause immunopathology. Here, we studied the response of mucosal-associated invariant T (MA…
View article: Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR redirection
Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR redirection Open
Progress in our understanding of MR1-restricted mucosa-associated invariant T (MAIT) cells has raised interest in harnessing these cells for immunotherapy. The innate-like response characteristics, abundance in the blood, donor-unrestricte…
View article: The effect of HIV-1 infection on Fcγ receptor signalling and function
The effect of HIV-1 infection on Fcγ receptor signalling and function Open
This thesis was scanned from the print manuscript for digital preservation and is copyright the author. Researchers can access this thesis by asking their local university, institution or public library to make a request on their behalf. M…
View article: Preserved Mucosal-Associated Invariant T-Cell Numbers and Function in Idiopathic CD4 Lymphocytopenia
Preserved Mucosal-Associated Invariant T-Cell Numbers and Function in Idiopathic CD4 Lymphocytopenia Open
Background Mucosal-associated invariant T (MAIT) cells constitute a subset of unconventional, MR1-restricted T cells involved in antimicrobial responses as well as inflammatory, allergic, and autoimmune diseases. Chronic infection and infl…
View article: Emerging Role for MAIT Cells in Control of Antimicrobial Resistance
Emerging Role for MAIT Cells in Control of Antimicrobial Resistance Open
Antimicrobial resistance is a serious threat to global public health as antibiotics are losing effectiveness due to rapid development of resistance. The human immune system facilitates control and clearance of resistant bacterial populatio…
View article: Longitudinal Analysis of Peripheral and Colonic CD161+ CD4+ T Cell Dysfunction in Acute HIV-1 Infection and Effects of Early Treatment Initiation
Longitudinal Analysis of Peripheral and Colonic CD161+ CD4+ T Cell Dysfunction in Acute HIV-1 Infection and Effects of Early Treatment Initiation Open
CD161 expression on CD4+ T cells is associated with a Th17 functional phenotype, as well as with an innate capacity to respond to interleukin (IL)-12 and IL-18 without T cell receptor (TCR) stimulation. Chronic HIV-1 infection is associate…
View article: Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli
Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli Open
Mucosa-associated invariant T (MAIT) cells are abundant antimicrobial T cells in humans and recognize antigens derived from the microbial riboflavin biosynthetic pathway presented by the MHC-Ib-related protein (MR1). However, the mechanism…
View article: Opsonization-Enhanced Antigen Presentation by MR1 Activates Rapid Polyfunctional MAIT Cell Responses Acting as an Effector Arm of Humoral Antibacterial Immunity
Opsonization-Enhanced Antigen Presentation by MR1 Activates Rapid Polyfunctional MAIT Cell Responses Acting as an Effector Arm of Humoral Antibacterial Immunity Open
Mucosa-associated invariant T (MAIT) cells are innate-like antimicrobial T cells recognizing a breadth of important pathogens via presentation of microbial riboflavin metabolite Ags by MHC class Ib–related (MR1) molecules. However, the int…
View article: Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in<i>Escherichia coli</i>
Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in<i>Escherichia coli</i> Open
Mucosa-associated invariant T (MAIT) cells are abundant antimicrobial T cells in humans, and recognize antigens derived from the microbial riboflavin biosynthetic pathway presented by the MHC-Ib-related protein (MR1). However, the mechanis…
View article: Recruitment of MAIT Cells to the Intervillous Space of the Placenta by Placenta-Derived Chemokines
Recruitment of MAIT Cells to the Intervillous Space of the Placenta by Placenta-Derived Chemokines Open
The intervillous space of the placenta is a part of the fetal-maternal interface, where maternal blood enters to provide nutrients and gas exchange. Little is known about the maternal immune cells at this site, which are in direct contact …
View article: The CD4<sup>−</sup>CD8<sup>−</sup>MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8<sup>+</sup>MAIT cell pool
The CD4<sup>−</sup>CD8<sup>−</sup>MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8<sup>+</sup>MAIT cell pool Open
Significance Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells recognizing microbial riboflavin metabolites presented by the monomorphic MR1 molecule. Here, we show that the CD8 + CD4 − and CD8 − CD4 − subpo…
View article: Tissue‐resident MAIT cell populations in human oral mucosa exhibit an activated profile and produce IL‐17
Tissue‐resident MAIT cell populations in human oral mucosa exhibit an activated profile and produce IL‐17 Open
Mucosa‐associated invariant T (MAIT) cells are unconventional T lymphocytes defined by their innate‐like characteristics and broad antimicrobial responsiveness. Whether MAIT cells are part of the tissue‐resident defense in the oral mucosal…
View article: Factors Influencing Functional Heterogeneity in Human Mucosa-Associated Invariant T Cells
Factors Influencing Functional Heterogeneity in Human Mucosa-Associated Invariant T Cells Open
Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells that recognize microbial riboflavin metabolites presented by the monomorphic MHC class I-related (MR1) molecule. Despite the high level of evolutionary conse…