Edwin Liu
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View article: Screening the general population for celiac disease: Lessons from the first international symposium held in Denver 2024
Screening the general population for celiac disease: Lessons from the first international symposium held in Denver 2024 Open
View article: Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study
Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study Open
In 2025, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health celebrates 75 years of leadership in diabetes research. The NIDDK serves people of the U.S. affected by or at risk f…
View article: Assessing Mucosal Recovery During the First 15 Months of Adopting a Gluten-Free Diet in Children With Celiac Disease
Assessing Mucosal Recovery During the First 15 Months of Adopting a Gluten-Free Diet in Children With Celiac Disease Open
INTRODUCTION: Determine contemporary rates of early mucosal recovery in children with celiac disease (CeD). METHODS: Multicenter retrospective cohort study in Canada and the United States. Children diagnosed with CeD between 2016 and 2021 …
View article: Risk of celiac disease autoimmunity is modified by interactions between CD247 and environmental exposures
Risk of celiac disease autoimmunity is modified by interactions between CD247 and environmental exposures Open
View article: Outcomes of pediatric endoscopic ultrasound‐guided celiac plexus block: A single center pilot study
Outcomes of pediatric endoscopic ultrasound‐guided celiac plexus block: A single center pilot study Open
Celiac plexus blocks (CPBs) using endoscopic ultrasound (EUS) guidance provide significant pain relief in adults with chronic pancreatitis. We present on EUS‐guided CPB for pediatric patients with abdominal pain from chronic pancreatitis o…
View article: Early Appearance of Thyroid Autoimmunity in Children Followed From Birth for Type 1 Diabetes Risk
Early Appearance of Thyroid Autoimmunity in Children Followed From Birth for Type 1 Diabetes Risk Open
Context Autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) define preclinical autoimmune thyroid disease (AITD), which can progress to either clinical hypothyroidism or hyperthyroidism. Objective We determined the age at…
View article: Recommendations for the management of gastrointestinal comorbidities with or without trofinetide use in Rett syndrome
Recommendations for the management of gastrointestinal comorbidities with or without trofinetide use in Rett syndrome Open
Although gastrointestinal (GI) comorbidities are experienced by over 90% of individuals with Rett syndrome (RTT), a neurodevelopmental disorder associated with mutations in the
View article: Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study
Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study Open
View article: Coeliac disease: what can we learn from prospective studies about disease risk?
Coeliac disease: what can we learn from prospective studies about disease risk? Open
View article: Associations of dietary patterns between age 9 and 24 months with risk of celiac disease autoimmunity and celiac disease among children at increased risk
Associations of dietary patterns between age 9 and 24 months with risk of celiac disease autoimmunity and celiac disease among children at increased risk Open
Dietary patterns in early childhood are associated with risk of CDA and celiac disease in genetically predisposed children, independent of gluten intake.
View article: Anxiety and Risk Perception in Parents of Children Identified by Population Screening as High Risk for Type 1 Diabetes
Anxiety and Risk Perception in Parents of Children Identified by Population Screening as High Risk for Type 1 Diabetes Open
OBJECTIVE To assess anxiety and risk perception among parents whose children screened positive for islet autoantibodies, indicating elevated risk for type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS The Autoimmunity Screening for Kids (A…
View article: Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study
Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study Open
OBJECTIVE To investigate gastrointestinal infection episodes (GIEs) in relation to the appearance of islet autoantibodies in The Environmental Determinants of Diabetes in the Young (TEDDY) cohort. RESEARCH DESIGN AND METHODS GIEs on risk o…
View article: Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5- to 15-Year-Old Children Followed in the TEDDY Study
Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5- to 15-Year-Old Children Followed in the TEDDY Study Open
OBJECTIVE This study investigated physical activity and its association with the development of islet autoimmunity and type 1 diabetes in genetically at-risk children aged 5–15 years. RESEARCH DESIGN AND METHODS As part of the longitudinal…
View article: Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study
Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study Open
OBJECTIVE To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS In The Environmental …
View article: Gluten-free diet adherence in children with screening-detected celiac disease using a prospective birth cohort study
Gluten-free diet adherence in children with screening-detected celiac disease using a prospective birth cohort study Open
Background Celiac disease has an increasing incidence worldwide and is treated with lifelong adherence to a gluten-free diet. We aimed to describe gluten-free diet adherence rates in children with screening-identified celiac disease, deter…
View article: 229 A2B530, an autologous CEA-directed Tmod T-cell therapy with an inhibitory receptor gated by HLA-A*02 to target colorectal, pancreatic, and lung cancer
229 A2B530, an autologous CEA-directed Tmod T-cell therapy with an inhibitory receptor gated by HLA-A*02 to target colorectal, pancreatic, and lung cancer Open
Background Nearly all colorectal and most pancreatic and lung cancers express carcinoembryonic antigen (CEA). However, due to its expression in normal gut epithelial cells, CEA-targeted therapies have resulted in on-target, off-tumor toxic…
View article: Incidence of Pediatric Celiac Disease Varies by Region
Incidence of Pediatric Celiac Disease Varies by Region Open
INTRODUCTION: The Environmental Determinants of Diabetes in the Young study follows an HLA risk selected birth cohort for celiac disease (CD) development using a uniform protocol. Children under investigation come from 6 different regions …
View article: Multi-Omics Assessment of Genetic Risk for Celiac Disease in Down Syndrome
Multi-Omics Assessment of Genetic Risk for Celiac Disease in Down Syndrome Open
Objectives Individuals with Down syndrome (DS) display high risk of celiac disease (CD), but the mechanisms underlying this increased susceptibility await elucidation. Here, we examined the prevalence of HLA genotypes associated with CD ri…
View article: Characteristics of Children With Inflammatory Bowel Disease and Coexisting Celiac Disease Seropositivity
Characteristics of Children With Inflammatory Bowel Disease and Coexisting Celiac Disease Seropositivity Open
Objectives: Celiac disease (CeD) autoimmunity and coexisting inflammatory bowel disease (IBD) present a diagnostic dilemma. Our aims were to describe the phenotype of children with IBD and CeD seropositivity and evaluate provider confidenc…
View article: Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study
Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study Open
OBJECTIVE To distinguish among predictors of seroconversion, progression to multiple autoantibodies and from multiple autoantibodies to type 1 diabetes in young children. RESEARCH DESIGN AND METHODS Genetically high-risk newborns (n = 8,50…
View article: Rising Hemoglobin A1c in the Nondiabetic Range Predicts Progression of Type 1 Diabetes As Well As Oral Glucose Tolerance Tests
Rising Hemoglobin A1c in the Nondiabetic Range Predicts Progression of Type 1 Diabetes As Well As Oral Glucose Tolerance Tests Open
OBJECTIVE Biomarkers predicting risk of type 1 diabetes (stage 3) among children with islet autoantibodies are greatly needed to prevent diabetic ketoacidosis and facilitate prevention therapies. RESEARCH DESIGN AND METHODS Children in the…
View article: Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study
Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study Open
View article: Author Correction: A combined risk score enhances prediction of type 1 diabetes among susceptible children
Author Correction: A combined risk score enhances prediction of type 1 diabetes among susceptible children Open
View article: Is staff consistency important to parents’ satisfaction in a longitudinal study of children at risk for type 1 diabetes: the TEDDY study
Is staff consistency important to parents’ satisfaction in a longitudinal study of children at risk for type 1 diabetes: the TEDDY study Open
Background Participants’ study satisfaction is important for both compliance with study protocols and retention, but research on parent study satisfaction is rare. This study sought to identify factors associated with parent study satisfac…
View article: EDS‐related Feeding Difficulties
EDS‐related Feeding Difficulties Open
Feeding difficulties due to functional gastrointestinal (GI) symptoms (i.e., nausea, pain, and bloating) are well described in patients with hypermobile‐type Ehlers‐Danlos Syndrome. These symptoms are particularly difficult to treat when t…
View article: Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes
Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes Open
View article: 122 A powerful, precise targeting system controlled by tumor deletions transforms CEA and MSLN CAR-T cells into tumor-selective agents
122 A powerful, precise targeting system controlled by tumor deletions transforms CEA and MSLN CAR-T cells into tumor-selective agents Open
Background Mesothelin (MSLN) and carcinoembryonic antigen (CEA) are classic tumor-associated antigens that are expressed in many solid tumors including the majority of lung, colorectal and pancreatic cancers. However, both MSLN and CEA are…
View article: An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood
An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood Open
OBJECTIVE Islet autoimmunity develops before clinical type 1 diabetes and includes multiple and single autoantibody phenotypes. The objective was to determine age-related risks of islet autoantibodies that reflect etiology and improve scre…
View article: Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity
Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity Open
View article: Telehealth and Nutrition Support During the COVID-19 Pandemic
Telehealth and Nutrition Support During the COVID-19 Pandemic Open