Explanipedia

Dir-based dose accumulation for parotid glands in head and neck cancer: Accuracy and implications for adaptive radiotherapy Open

Yong Gan, Johannes A. Langendijk, Edwin Oldehinkel, Zhixiong Lin, Stefan Both , et al. · 2025

Significant discrepancies were observed in accumulated D_mean of parotid glands between DIR and manual segmentation in candidates for adaptive radiotherapy. Utilizing mid-treatment CT scans offers a practical solution to correct …

Toxicity and Quality of Life After Locoregional Radiotherapy in Patients With Thyroid Cancer Open

Job W. van den End, Eline C. Jager, Hans H G Verbeek, Edwin Oldehinkel, Liesbeth Jansen , et al. · 2025

Background Locoregional external beam radiotherapy (EBRT) is selectively used in thyroid cancer patients to induce locoregional control. However, despite technological advances, EBRT remains associated with toxicities. We evaluated thyroid…

Blood biomarkers for cardiac damage during and after radiotherapy for esophageal cancer: A prospective cohort study Open

Jannet C. Beukema, Jan-Willem Haveman, Johannes A. Langendijk, Edwin Oldehinkel, A.C.M. van den Bergh , et al. · 2024

Significant correlations were found for both biomarkers with radiation dose and clinical toxicity endpoints after treatment. Therefore, these markers might be of additional value in NTCP models for cardiac events and might help us unravell…

Optimal timing of re-planning for head and neck adaptive radiotherapy Open

Yong Gan, Johannes A. Langendijk, Edwin Oldehinkel, Zhixiong Lin, Stefan Both , et al. · 2024

The optimal timing of re-planning was suggested for different organs at risk in head and neck adaptive radiotherapy. Generic scenarios of timing and frequency for re-planning can be applied to guarantee the increase of accumulated mean dos…

External validation of a lung cancer-based prediction model for two-year mortality in esophageal cancer patient cohorts Open

Maaike Berbée, Christina T. Muijs, Francine E.M. Voncken, Leonard Wee, Meindert N. Sosef , et al. · 2023

Assessment of residual geometrical errors of clinical target volumes and their impact on dose accumulation for head and neck radiotherapy Open

Kelvin Ng Wei Siang, Stefan Both, Edwin Oldehinkel, Johannes A. Langendijk, Dirk Wagenaar · 2023

Setup uncertainty setting of 2 mm is possible. The feasibility of using propagated CTVs for error determination is demonstrated.

Challenges and opportunities for proton therapy during pregnancy Open

Jeroen Blommaert, Marijke De Saint‐Hubert, Tom Depuydt, Edwin Oldehinkel, Philip Poortmans , et al. · 2023

During pregnancy, the use of radiation therapy for cancer treatment is often considered impossible due to the assumed associated fetal risks. However, suboptimal treatment of pregnant cancer patients and unjustifiable delay in radiation th…

An efficient strategy to select head and neck cancer patients for adaptive radiotherapy Open

Yong Gan, Johannes A. Langendijk, A. van der Schaaf, L. Van den Bosch, Edwin Oldehinkel , et al. · 2023

Proton therapy of a pregnant patient with nasopharyngeal carcinoma Open

Joosje H. Heimovaara, Jeroen Blommaert, Jeffrey Free, René A. Bolt, Elske M. Gort , et al. · 2022

Impact of sarcopenia on acute radiation-induced toxicity in head and neck cancer patients Open

Eleftheria Karavolia, Maria I. van Rijn–Dekker, L. Van den Bosch, Johanna G.M. van den Hoek, Edwin Oldehinkel , et al. · 2022

Sarcopenia in HNC patients was an independent prognostic factor for radiation-induced physician-rated acute grade ≥ 3 dysphagia, which might be explained by its impact on swallowing muscles. However, addition of sarcopenia did not improve …

Evaluation of robustly optimised intensity modulated proton therapy for nasopharyngeal carcinoma Open

D. Scandurra, Tineke W.H. Meijer, Jeffrey Free, Johanna G.M. van den Hoek, Lotta Kelder , et al. · 2022

Robustly optimised IMPT plans, in combination with volumetric verification imaging and adaptive planning, provided robust target coverage and acceptable OAR dose variation in our NPC cohort when accumulated over longitudinal data.

A novel semi auto-segmentation method for accurate dose and NTCP evaluation in adaptive head and neck radiotherapy Open

Yong Gan, Johannes A. Langendijk, Edwin Oldehinkel, D. Scandurra, Nanna M. Sijtsema , et al. · 2021

Human segmentation of the parotid glands remains necessary for accurate interpretation of mean dose and NTCP during ART. Proposed semi auto-segmentation allows NTCP-predictions within 1.5% accuracy for 90% of the cases.

Patient-Reported Toxicity and Quality-of-Life Profiles in Patients With Head and Neck Cancer Treated With Definitive Radiation Therapy or Chemoradiation Open

L. Van den Bosch, Hans Paul van der Laan, A. van der Schaaf, Sjoukje F. Oosting, György B. Halmos , et al. · 2021

We established patient-reported toxicity and quality-of-life profiles that showed different patterns for 3 subgroups of patients with HNC. These profiles provide detailed information on the severity and persistence of various symptoms as e…

Development of advanced preselection tools to reduce redundant plan comparisons in model-based selection of head and neck cancer patients for proton therapy Open

Makbule Tambaş, Hans Paul van der Laan, W. Rutgers, Johanna G.M. van den Hoek, Edwin Oldehinkel , et al. · 2021

Spleen Dose Influences Overall Survival In The Neo-Adjuvant Treatment Of Esophageal Cancer Open

C.T. Muijs, Edwin Oldehinkel, Margriet Dieters, Véronique E. Mul, A. Nieznik , et al. · 2020

First experience with model-based selection of head and neck cancer patients for proton therapy Open

Makbule Tambaş, Roel J.H.M. Steenbakkers, Hans Paul van der Laan, Atje M. Wolters, R.G.J. Kierkels , et al. · 2020

Model-based selection of patients with HNC for proton therapy is clinically feasible. Approximately one third of HNC patients qualify for protons and these patients have the highest probability to benefit from protons in terms of toxicity …

PV-0101: Impact of cardiac dose on survival and toxicity after neo-adjuvant treatment for esophageal cancer Open

Edwin Oldehinkel, M. Heiden, Jannet C. Beukema, M. Dieters, A.C.M. van den Bergh , et al. · 2018

PV-0102: Cardiopulmonary toxicity after tri-modality treatment versus surgery alone for esophageal cancer Open

M. Heiden, Edwin Oldehinkel, Jannet C. Beukema, Dirk J. Bosch, John Th. M. Plukker , et al. · 2018

Edwin Oldehinkel YOU? Author Swipe