Edwin Yoo
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View article: Low Dose GLP-1 Therapy Attenuates Pathological Cardiac and Hepatic Remodelling in HFpEF Independent of Weight Loss
Low Dose GLP-1 Therapy Attenuates Pathological Cardiac and Hepatic Remodelling in HFpEF Independent of Weight Loss Open
BACKGROUND AND AIMS Heart failure with preserved ejection fraction (HFpEF) remains a therapeutic challenge. GLP-1 receptor agonists (GLP-1RAs) show clinical promise, and the prevailing hypothesis is that their benefits are primarily driven…
View article: Myocardial Proteome in Human Heart Failure With Preserved Ejection Fraction
Myocardial Proteome in Human Heart Failure With Preserved Ejection Fraction Open
Background Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all HF but has few effective therapies. Recent human myocardial transcriptomics and metabolomics have identified major differences between HFpE…
View article: WITHDRAWN: Cross-species Myocardial Proteomics For Animal Models of Cardiometabolic Heart Failure With Preserved Ejection Fraction
WITHDRAWN: Cross-species Myocardial Proteomics For Animal Models of Cardiometabolic Heart Failure With Preserved Ejection Fraction Open
Withdrawal Statement The authors have withdrawn their manuscript owing to insufficient sample size to make conclusions. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, pleas…
View article: Green Lab Nanoparticle For 6 Well Cardiomyocyte Transfection v2 v2
Green Lab Nanoparticle For 6 Well Cardiomyocyte Transfection v2 v2 Open
nanoparticle transfection
View article: Myocardial Metabolomics of Human Heart Failure With Preserved Ejection Fraction
Myocardial Metabolomics of Human Heart Failure With Preserved Ejection Fraction Open
Background: The human heart primarily metabolizes fatty acids, and this decreases as alternative fuel use rises in heart failure with reduced ejection fraction (HFrEF). Patients with severe obesity and diabetes are thought to have increase…
View article: Sidoli Phosphoenrichment From Clean Dry Peptides v1
Sidoli Phosphoenrichment From Clean Dry Peptides v1 Open
Sidoli Phosphoenrichment From Clean Dry Peptides
View article: Green Lab Nanoparticle For 6 Well Cardiomyocyte Transfection v1
Green Lab Nanoparticle For 6 Well Cardiomyocyte Transfection v1 Open
nanoparticle transfection
View article: Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue
Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue Open
Flat cultures of mammalian cells are a widely used in vitro approach for understanding cell physiology, but this system is limited in modeling solid tissues due to unnaturally rapid cell replication. This is particularly challenging when m…
View article: Cardiovascular Disease and Severe Hypoxemia Are Associated With Higher Rates of Noninvasive Respiratory Support Failure in Coronavirus Disease 2019 Pneumonia
Cardiovascular Disease and Severe Hypoxemia Are Associated With Higher Rates of Noninvasive Respiratory Support Failure in Coronavirus Disease 2019 Pneumonia Open
Objectives: Acute hypoxemic respiratory failure is the major complication of coronavirus disease 2019, yet optimal respiratory support strategies are uncertain. We aimed to describe outcomes with high-flow oxygen delivered through nasal ca…
View article: Cardiovascular disease and severe hypoxemia associated with higher rates of non-invasive respiratory support failure in COVID-19
Cardiovascular disease and severe hypoxemia associated with higher rates of non-invasive respiratory support failure in COVID-19 Open
Rationale Acute hypoxemic respiratory failure (AHRF) is the major complication of coronavirus disease 2019 (COVID-19), yet optimal respiratory support strategies are uncertain. Objectives To describe outcomes with high-flow oxygen delivere…
View article: Development and calibration of a simple mortality risk score for hospitalized COVID-19 adults
Development and calibration of a simple mortality risk score for hospitalized COVID-19 adults Open
Objectives Mortality risk scores, such as SOFA, qSOFA, and CURB-65, are quick, effective tools for communicating a patient’s prognosis and guiding therapeutic decisions. Most use simple calculations that can be performed by hand. While sev…
View article: TGF-β1 Evokes Human Airway Smooth Muscle Cell Shortening and Hyperresponsiveness via Smad3
TGF-β1 Evokes Human Airway Smooth Muscle Cell Shortening and Hyperresponsiveness via Smad3 Open
Transforming growth factor β1 (TGF-β1), a cytokine whose levels are elevated in the airways of patients with asthma, perpetuates airway inflammation and modulates airway structural cell remodeling. However, the role of TGF-β1 in excessive …
View article: Gα<sub>12</sub> facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3‐kinase‐mediated activation in a RhoA‐dependent manner
Gα<sub>12</sub> facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3‐kinase‐mediated activation in a RhoA‐dependent manner Open
Background and Purpose PI3K‐dependent activation of Rho kinase (ROCK) is necessary for agonist‐induced human airway smooth muscle cell (HASMC) contraction, and inhibition of PI3K promotes bronchodilation of human small airways. The mechani…
View article: Transforming Growth Factor β1 Function in Airway Remodeling and Hyperresponsiveness. The Missing Link?
Transforming Growth Factor β1 Function in Airway Remodeling and Hyperresponsiveness. The Missing Link? Open
The pathogenesis of asthma includes a complex interplay among airway inflammation, hyperresponsiveness, and remodeling. Current evidence suggests that airway structural cells, including bronchial smooth muscle cells, myofibroblasts, fibrob…
View article: Targeting Calcium Sensitization Mechanisms in Human Airway Smooth Muscle for Novel Bronchodilator Therapy in Asthma
Targeting Calcium Sensitization Mechanisms in Human Airway Smooth Muscle for Novel Bronchodilator Therapy in Asthma Open
Asthma is characterized by airway hyperresponsiveness (AHR) and inflammation. Management of asthma involves controlling airway inflammation with inhaled corticosteroids, and using bronchodilators such as β-2 agonists that inhibit airway sm…
View article: Inhibition of PI3K promotes dilation of human small airways in a rho kinase‐dependent manner
Inhibition of PI3K promotes dilation of human small airways in a rho kinase‐dependent manner Open
Background and Purpose Asthma manifests as a heterogeneous syndrome characterized by airway obstruction, inflammation and hyperresponsiveness (AHR). Although the molecular mechanisms remain unclear, activation of specific PI3K isoforms med…
View article: Formaldehyde Induces Rho-Associated Kinase Activity to Evoke Airway Hyperresponsiveness
Formaldehyde Induces Rho-Associated Kinase Activity to Evoke Airway Hyperresponsiveness Open
Formaldehyde, a common indoor air pollutant, exacerbates asthma and synergizes with allergen to induce airway hyperresponsiveness (AHR) in animal models. The mechanisms mediating formaldehyde-induced AHR remain poorly understood. We posit …
View article: Epithelium-generated neuropeptide Y induces smooth muscle contraction to promote airway hyperresponsiveness
Epithelium-generated neuropeptide Y induces smooth muscle contraction to promote airway hyperresponsiveness Open
Asthma is one of the most common chronic diseases globally and can be divided into presenting with or without an immune response. Current therapies have little effect on nonimmune disease, and the mechanisms that drive this type of asthma …