Edyta Marcon
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View article: 215 Innovating Medical Education: A translational approach to integrating cannabinoid-based therapies for chronic pain management
215 Innovating Medical Education: A translational approach to integrating cannabinoid-based therapies for chronic pain management Open
Objectives/Goals: This project aims to inform and develop a clinician-centered educational tool evidence-based and stakeholder-informed that fosters healthcare professionals’ (HCPs) adaptive expertise (AE) in cannabinoid-based therapies (C…
View article: 571 A catalyst for change: Elevating mental health considerations in Ontario using a mental health in all policies approach
571 A catalyst for change: Elevating mental health considerations in Ontario using a mental health in all policies approach Open
Objectives/Goals: Our goal for this project is to develop a metric that integrates the intersectional social and structural determinants of health and well-being into the existing policy development framework to impact the integration of s…
View article: 549 Mental health care for patients with potential decision-making capacity compromise: Challenging Ontario’s mental healthcare legislation
549 Mental health care for patients with potential decision-making capacity compromise: Challenging Ontario’s mental healthcare legislation Open
Objectives/Goals: How do we care for a patient whose mental health is deteriorated such that their decision-making capacity may be compromised? The high-potency opioid crisis in Ontario demands that we provide effective care for the affect…
View article: Identifying human pre-mRNA cleavage and polyadenylation factors by genome-wide CRISPR screens using a dual fluorescence readthrough reporter
Identifying human pre-mRNA cleavage and polyadenylation factors by genome-wide CRISPR screens using a dual fluorescence readthrough reporter Open
Messenger RNA precursors (pre-mRNA) generally undergo 3′ end processing by cleavage and polyadenylation (CPA), which is specified by a polyadenylation site (PAS) and adjacent RNA sequences and regulated by a large variety of core and auxil…
View article: 237 Empowering Youth in Mental Health Treatment: A Co-Designed Approach to Measurement-Based Care
237 Empowering Youth in Mental Health Treatment: A Co-Designed Approach to Measurement-Based Care Open
OBJECTIVES/GOALS: This integrated knowledgetranslationproject aims to increase youth engagement in mental health services through enhancing shared decision-making processes. To do this, a knowledge product to support greater involvement in…
View article: 93 Investigating the minimal requirements for startup procurement by healthcare institutions in Ontario, Canada
93 Investigating the minimal requirements for startup procurement by healthcare institutions in Ontario, Canada Open
OBJECTIVES/GOALS: The primarygoal is to understand the challenges and barriers associated with the procurement of innovative technologies.Specifically, our research will answer the following question: what are the minimal requirements for …
View article: A110 INVOLVING STAKEHOLDERS TO DEVELOP BREASTFEEDING EDUCATIONAL RESOURCES FOR PATIENTS WITH INFLAMMATORY DISEASE
A110 INVOLVING STAKEHOLDERS TO DEVELOP BREASTFEEDING EDUCATIONAL RESOURCES FOR PATIENTS WITH INFLAMMATORY DISEASE Open
Background Inflammatory Bowel Disease (IBD) are incurable chronic inflammatory disease of the digestive tract that is often treated with immunosuppressive medications. Common IBD symptoms are frequent bowel movements that may be accompanie…
View article: Recruitment of the m <sup>6</sup> A/Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48
Recruitment of the m <sup>6</sup> A/Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48 Open
N6-methyladenosine (m6A), the most abundant internal modification on eukaryotic mRNA, and N6, 2′-O-dimethyladenosine (m6Am), are epitranscriptomic marks that function in multiple aspects of posttranscriptional regulation. Fat mass and obes…
View article: 93 Investigating the minimal requirements for startup procurement by healthcare institutions in Ontario, Canada – CORRIGENDUM
93 Investigating the minimal requirements for startup procurement by healthcare institutions in Ontario, Canada – CORRIGENDUM Open
[This corrects the article DOI: 10.1017/cts.2024.91.].
View article: Changes in SUMO-modified proteins in Epstein-Barr virus infection identifies reciprocal regulation of TRIM24/28/33 complexes and the lytic switch BZLF1
Changes in SUMO-modified proteins in Epstein-Barr virus infection identifies reciprocal regulation of TRIM24/28/33 complexes and the lytic switch BZLF1 Open
SUMO modifications regulate the function of many proteins and are important in controlling herpesvirus infections. We performed a site-specific proteomic analysis of SUMO1- and SUMO2-modified proteins in Epstein-Barr virus (EBV) latent and…
View article: Collaborative Application of Resilience Education (CARE): Fostering Resilience to Combat Depression and Anxiety in Graduate Students
Collaborative Application of Resilience Education (CARE): Fostering Resilience to Combat Depression and Anxiety in Graduate Students Open
Background: Graduate students experience depression and anxiety at rates six times higher than the general population. A literature review of resilience education and an environmental scan of existing preventative resources found that curr…
View article: Omicron Spike Protein Is Vulnerable to Reduction
Omicron Spike Protein Is Vulnerable to Reduction Open
SARS-CoV-2 virus spike (S) protein is an envelope protein responsible for binding to the ACE2 receptor, driving subsequent entry into host cells. The existence of multiple disulfide bonds in the S protein makes it potentially susceptible t…
View article: Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors
Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors Open
SARS-CoV-2 depends on host cell components for infection and replication. Identification of virus-host dependencies offers an effective way to elucidate mechanisms involved in viral infection and replication. If druggable, host factor depe…
View article: EP384/#926 Cost-analysis of an enhanced recovery program after minimally invasive gynecologic oncology surgery
EP384/#926 Cost-analysis of an enhanced recovery program after minimally invasive gynecologic oncology surgery Open
Objectives A perioperative quality improvement initiative for minimally invasive (MIS) gynecologic oncology surgery at our centre improved the rate of same day discharge (SDD) from 29% to 75%. The current study aims to estimate the project…
View article: An Examination of Utilization Rates Over Time of Nerve and Tendon Transfers in Canada to Improve Upper Limb Function in Cervical Spinal Cord Injury
An Examination of Utilization Rates Over Time of Nerve and Tendon Transfers in Canada to Improve Upper Limb Function in Cervical Spinal Cord Injury Open
Introduction: Upper limb function loss in cervical spinal cord injury (SCI) contributes to substantial disability, and negatively impacts quality of life. Nerve transfer and tendon transfer surgery can provide improved upper limb function.…
View article: Epstein-Barr Virus BGLF2 commandeers RISC to interfere with cellular miRNA function
Epstein-Barr Virus BGLF2 commandeers RISC to interfere with cellular miRNA function Open
The Epstein-Barr virus (EBV) BGLF2 protein is a tegument protein with multiple effects on the cellular environment, including induction of SUMOylation of cellular proteins. Using affinity-purification coupled to mass-spectrometry, we ident…
View article: Chemoproteomic Analysis of an NSD2-PWWP1 Chemical Probe
Chemoproteomic Analysis of an NSD2-PWWP1 Chemical Probe Open
Dataset details Project Title: Chemoproteomic Analysis of an NSD2-PWWP1 Chemical Probe Keywords: chemoproteomics, epigenetics, chemical probe, histone methyltransferase Project description: Here we use competitive chemoproteomics pulldowns…
View article: Chemoproteomic Analysis of an NSD2-PWWP1 Chemical Probe
Chemoproteomic Analysis of an NSD2-PWWP1 Chemical Probe Open
Dataset details Project Title: Chemoproteomic Analysis of an NSD2-PWWP1 Chemical Probe Keywords: chemoproteomics, epigenetics, chemical probe, histone methyltransferase Project description: Here we use competitive chemoproteomics pulldowns…
View article: Characterization of a cancer-associated Epstein-Barr virus EBNA1 variant reveals a novel interaction with PLOD1 and PLOD3
Characterization of a cancer-associated Epstein-Barr virus EBNA1 variant reveals a novel interaction with PLOD1 and PLOD3 Open
Whole genome sequence analysis of Epstein-Barr virus genomes from tumours and healthy individuals identified three amino acid changes in EBNA1 that are strongly associated with gastric carcinoma and nasopharyngeal carcinoma. Here we show t…
View article: Systematic genome-scale identification of host factors for SARS-CoV-2 infection across models yields a core single gene dependency; <i>ACE2</i>
Systematic genome-scale identification of host factors for SARS-CoV-2 infection across models yields a core single gene dependency; <i>ACE2</i> Open
SUMMARY SARS-CoV-2, depends on host cell components for replication, therefore the identification of virus-host dependencies offers an effective way to elucidate mechanisms involved in viral infection. Such host factors may be necessary fo…
View article: Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential
Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential Open
COVID-19 mortality is primarily driven by abnormal alveolar fluid metabolism of the lung, leading to fluid accumulation in the alveolar airspace. This condition is generally referred to as pulmonary edema and is a direct consequence of sev…
View article: Functional characterization of RebL1 highlights the evolutionary conservation of oncogenic activities of the RBBP4/7 orthologue in <i>Tetrahymena thermophila</i>
Functional characterization of RebL1 highlights the evolutionary conservation of oncogenic activities of the RBBP4/7 orthologue in <i>Tetrahymena thermophila</i> Open
Retinoblastoma-binding proteins 4 and 7 (RBBP4 and RBBP7) are two highly homologous human histone chaperones. They function in epigenetic regulation as subunits of multiple chromatin-related complexes and have been implicated in numerous c…
View article: Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization
Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization Open
NSD2 is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36me2), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methyltransferase domain, NSD2 harbors two…