Explanipedia

Loss of PI3Kδ Activity Drives Autoimmune Colitis by Impairing Extrathymic Treg Differentiation Open

Ee Lyn Lim, Yamin Qian, Fuminori Sugihara, Atsushi Tanaka, Shimon Sakaguchi · 2025

Peripherally derived regulatory T cells (pTregs) have a prominent role in maintaining intestinal immune homeostasis. In cases of phosphoinositide‐3‐kinase δ (PI3Kδ) inactivation, such as in patients receiving PI3Kδ inhibitor idelalisib as …

Loss of PI3Kδ activity drives autoimmune colitis by impairing extrathymic Treg differentiation Open

Ee Lyn Lim, Yamin Qian, Fuminori Sugihara, Atsushi Tanaka, Shimon Sakaguchi · 2024

Peripherally-derived regulatory T cells (pTregs) have a prominent role in maintaining intestinal immune homeostasis. In cases of phosphoinositide-3-kinase δ (PI3Kδ) inactivation, such as in patients receiving PI3Kδ inhibitor idelalisib as …

The TCRs of pathogenic Th17 cells in arthritogenic mice are shifted toward a Treg-like repertoire Open

Mara Anaís Llamas-Covarrubias, Atsushi Tanaka, Martin Loza, Diego Díez, Zichang Xu , et al. · 2024

Summary Mutations in the ZAP-70 gene that cause moderate attenuation of T cell receptor (TCR) signaling in mice can result in autoimmune manifestations. One explanation for this pathology is a shift in the regulatory-conventional (Treg-Tco…

Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease Open

Atsushi Tanaka, Shinji Maeda, Takashi Nomura, Mara Anaís Llamas-Covarrubias, Satoshi Tanaka , et al. · 2022

Thymic selection and peripheral activation of conventional T (Tconv) and regulatory T (Treg) cells depend on TCR signaling, whose anomalies are causative of autoimmunity. Here, we expressed in normal mice mutated ZAP-70 molecules with diff…

Phosphoinositide 3‐kinase <i>δ</i> is a regulatory T‐cell target in cancer immunotherapy Open

Ee Lyn Lim, Klaus Okkenhaug · 2019

Summary Tumour infiltration by regulatory T (Treg) cells contributes to suppression of the anti‐tumour immune response, which limits the efficacy of immune‐mediated cancer therapies. The phosphoinositide 3‐kinase ( PI 3K) pathway has key r…

Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody Open

Danbee Ha, Atsushi Tanaka, Tatsuya Kibayashi, Atsushi Tanemura, Daisuke Sugiyama , et al. · 2018

Significance Anti–CTLA-4 mAb is able to augment tumor immunity despite CTLA-4 expression by functionally opposing T cell populations: activated effector T (Teff) cells and FOXP3 + CD4 + Treg cells. Here we show that anti–CTLA-4 mAb enginee…

Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors Open

Ee Lyn Lim, Fiorella Cugliandolo, Dalya R. Soond, Dávid Győri, Rahul Roychoudhuri , et al. · 2018

Multiple modes of immunosuppression restrain immune function within tumors. We previously reported that phosphoinositide 3-kinase δ (PI3Kδ) inactivation in mice confers resistance to a range of tumor models by disrupting immunosuppression …

Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy Open

Dávid Győri, Ee Lyn Lim, Francis M. Grant, Dominik Spensberger, Rahul Roychoudhuri , et al. · 2018

Redundancy and compensation provide robustness to biological systems but may contribute to therapy resistance. Both tumor-associated macrophages (TAMs) and Foxp3+ regulatory T (Treg) cells promote tumor progression by limiting antitumor im…

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