Eelco D. Keuning
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View article: Tumor desialylation surpasses anti‐<scp>PD</scp>‐<scp>L1</scp> checkpoint therapy in restoring anti‐tumor immunity in a murine model for colorectal cancer
Tumor desialylation surpasses anti‐<span>PD</span>‐<span>L1</span> checkpoint therapy in restoring anti‐tumor immunity in a murine model for colorectal cancer Open
Abnormal levels of tumor‐associated glycans are correlated with tumor progression in many types of cancer, including (CRC). Sialic acids, a family of nine‐carbon monosaccharides, are key regulators of the anti‐tumor immune response via Sig…
View article: Vaccination with DC-SIGN-Targeting αGC Liposomes Leads to Tumor Control, Irrespective of Suboptimally Activated T-Cells
Vaccination with DC-SIGN-Targeting αGC Liposomes Leads to Tumor Control, Irrespective of Suboptimally Activated T-Cells Open
Cancer vaccines have emerged as a potent strategy to improve cancer immunity, with or without the combination of checkpoint blockade. In our investigation, liposomal formulations containing synthetic long peptides and α-Galactosylceramide,…
View article: Myeloid ATP Citrate Lyase Regulates Macrophage Inflammatory Responses In Vitro Without Altering Inflammatory Disease Outcomes
Myeloid ATP Citrate Lyase Regulates Macrophage Inflammatory Responses In Vitro Without Altering Inflammatory Disease Outcomes Open
Macrophages are highly plastic, key regulators of inflammation. Deregulation of macrophage activation can lead to excessive inflammation as seen in inflammatory disorders like atherosclerosis, obesity, multiple sclerosis and sepsis. Target…