Balwinder Singh
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View article: Antipsychotic use in bipolar disorder: clinical and genomic correlates– a Mayo clinic bipolar disorder biobank study
Antipsychotic use in bipolar disorder: clinical and genomic correlates– a Mayo clinic bipolar disorder biobank study Open
Background Responsiveness to mood-stabilizing pharmacotherapy varies in bipolar disorder (BD). We investigated clinical correlates of second-generation antipsychotic (SGA) treatment response and conducted the first genome-wide association …
View article: Clinical and biological distinctions between catatonia due to a medical condition and catatonia associated with a psychiatric disorder
Clinical and biological distinctions between catatonia due to a medical condition and catatonia associated with a psychiatric disorder Open
Our study suggests potential differences between individuals with CMC and CPD, pointing to the possibility of more precise, individualized care.
View article: Intravenous ketamine versus esketamine for depression: a systematic review and meta-analysis
Intravenous ketamine versus esketamine for depression: a systematic review and meta-analysis Open
Background: Depression affects approximately 5.7% of adults worldwide, and around one-third of these individuals develop treatment-resistant depression (TRD). Intravenous (IV) ketamine and esketamine (administered IV or intranasally (IN)) …
View article: Bridging Neurobiology, Heterogeneity, and Comorbidity in Mood Disorders
Bridging Neurobiology, Heterogeneity, and Comorbidity in Mood Disorders Open
Mood disorders are among the most disabling and complex psychiatric conditions, affecting millions worldwide and contributing substantially to morbidity, mortality, and healthcare utilization [...]
View article: Ketamine Reduces Suicidality-Associated Emergency Department Utilization in Patients With Treatment-Resistant Depression
Ketamine Reduces Suicidality-Associated Emergency Department Utilization in Patients With Treatment-Resistant Depression Open
Conclusions: Ketamine and esketamine reduced long-term ED visits for suicidality in individuals with TRD. Further longer-term follow-up research is encouraged to ascertain if these benefits on suicidality reduction are mood state dependent…
View article: A Cross‐Sectional Analysis of Social Determinants of Health in Bipolar Disorder: Exploring Gender‐Related Differences
A Cross‐Sectional Analysis of Social Determinants of Health in Bipolar Disorder: Exploring Gender‐Related Differences Open
Objectives To explore the clinical impact of social determinants of health (SDoH) stress in bipolar disorder (BD) course of illness and to explore potential gender differences in SDoH stress endorsement. Methods 2280 individuals living wit…
View article: Sodium-Glucose Cotransporter 2 Inhibitors for Lithium-Associated Kidney Dysfunction in Mood Disorders: A Real-World Historical Cohort Study
Sodium-Glucose Cotransporter 2 Inhibitors for Lithium-Associated Kidney Dysfunction in Mood Disorders: A Real-World Historical Cohort Study Open
Introduction Sodium-glucose cotransporter-2 inhibitors (SGLT2i), initially developed for type 2 diabetes, have shown promise in improving renal outcomes in patients with and without diabetes. However, their effect on lithium-associated kid…
View article: Randomized controlled trial of stress management and resiliency training for depression (SMART-D)-pilot study
Randomized controlled trial of stress management and resiliency training for depression (SMART-D)-pilot study Open
Objective Major Depressive Disorder (MDD) is characterized by high stress sensitivity and unsatisfactory response rates to standard treatments. Stress and depression share a bidirectional relationship. We, therefore, conducted a pilot rand…
View article: Defining Treatment‐Resistant Bipolar Depression: Recommendations From the <scp>ISBD</scp> Task Force
Defining Treatment‐Resistant Bipolar Depression: Recommendations From the <span>ISBD</span> Task Force Open
Objective Despite the availability of approved treatments, a substantial proportion of patients with bipolar disorder experience treatment‐resistant bipolar depression (TRBD), characterized by persistent depressive symptoms unresponsive to…
View article: Developing an IV Ketamine Clinic for Treatment-Resistant Depression: a Primer
Developing an IV Ketamine Clinic for Treatment-Resistant Depression: a Primer Open
The efficacy of subanesthetic intravenous ketamine for treatment resistant depression (TRD) has spurred a growth of clinics nationwide that provide this service. Ketamine is an FDA-approved drug as an anesthetic but remains unapproved for …
View article: Short Term Second-Generation Antidepressant Monotherapy in Acute Depressive Episodes of Bipolar II Disorder: A Systematic Review and Meta-Analysis
Short Term Second-Generation Antidepressant Monotherapy in Acute Depressive Episodes of Bipolar II Disorder: A Systematic Review and Meta-Analysis Open
Purpose Bipolar II disorder (BD-II) has limited evidence-based treatment guidelines. The aim of this systematic review and meta-analysis was to estimate the efficacy and safety of second-generation antidepressant (SGAD) monotherapy in acut…
View article: Persistence of Lithium Underutilization in Patients of African Ancestry with Bipolar Disorder
Persistence of Lithium Underutilization in Patients of African Ancestry with Bipolar Disorder Open
Bipolar disorder is a chronic disease that imposes a lifelong burden on those that suffer from it. Lithium is still considered both gold standard treatment and first-line maintenance treatment, and access to treatment with lithium is param…
View article: Lithium-Induced Hyperparathyroidism: An Ill-defined Territory
Lithium-Induced Hyperparathyroidism: An Ill-defined Territory Open
Lithium is the gold standard treatment for bipolar disorder. Studies have shown an association between lithium and hyperparathyroidism. However, there is limited data regarding the management of lithium-induced hyperparathyroidism. We pres…
View article: An Update on the Efficacy and Tolerability of Oral Ketamine for Major Depression: A Systematic Review and Meta-Analysis
An Update on the Efficacy and Tolerability of Oral Ketamine for Major Depression: A Systematic Review and Meta-Analysis Open
Background Intravenous Ketamine has shown robust antidepressant efficacy although other routes of administration are currently needed. We conducted a systematic review and meta-analysis of studies evaluating the efficacy and tolerability o…
View article: Antipsychotic Use in Bipolar Disorder: Clinical and Genomic Correlates– A Mayo Clinic Bipolar Disorder Biobank Study
Antipsychotic Use in Bipolar Disorder: Clinical and Genomic Correlates– A Mayo Clinic Bipolar Disorder Biobank Study Open
Background: Responsiveness to mood-stabilizing pharmacotherapy varies in bipolar disorder (BD). We investigated clinical correlates of second-generation antipsychotic (SGA) treatment response and conducted the first genome-wide association…
View article: Long-Term Outcomes in Patients With Treatment-Refractory Depression Receiving Intravenous Ketamine and Intranasal Esketamine
Long-Term Outcomes in Patients With Treatment-Refractory Depression Receiving Intravenous Ketamine and Intranasal Esketamine Open
Conclusion: This study provides evidence regarding longer durability of IV-KET compared to IN-ESKET. These findings need to be replicated in larger prospective studies and confirmed in a randomized controlled trial comparing these two trea…
View article: Relationship between profitability and capital structure: Financial performance of infrastructure companies of india
Relationship between profitability and capital structure: Financial performance of infrastructure companies of india Open
Shareholders' interests are the driving force of any business. Among other interests, one of the most important is maximizing wealth and making the best use of the company's revenues and proceedings. To accomplish this, one of the most imp…
View article: Invasive and Non-Invasive Neuromodulation for the Treatment of Substance Use Disorders: A Review of Reviews
Invasive and Non-Invasive Neuromodulation for the Treatment of Substance Use Disorders: A Review of Reviews Open
Background: Invasive and non-invasive neuromodulation in psychiatry represents a burgeoning field that leverages advanced neuromodulation techniques to address substance use disorders (SUDs). Aims: This narrative review synthesizes finding…
View article: High Baseline Plasma Anthranilic Acid Predicts Remission Upon Acute-Series Ketamine Infusion for Treatment-Resistant Depression
High Baseline Plasma Anthranilic Acid Predicts Remission Upon Acute-Series Ketamine Infusion for Treatment-Resistant Depression Open
Elevated AA levels and AA-based biomarker ratios predicted ketamine remission in patients with TRD, supporting biomarker-driven personalized treatment. These findings highlight immunometabolic mechanisms in ketamine response.
View article: Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part II
Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part II Open
Purpose/Background This is the second part of a 2-part article that proposes improving the United States (US) clozapine package insert. Part II focuses on fatal outcomes and the 5 boxed warnings, 4 specifically for clozapine: severe neutro…
View article: Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part I
Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part I Open
Purpose/Background Clozapine was approved in the United States (US) using 1989 regulations and knowledge. After 30 years, many sections of the US package insert (PI) are outdated. Methods We comprehensively reviewed the literature to propo…
View article: Prevalence of Dermatologic Side Effects of Mood Stabilizers in Bipolar Disorder: A Systematic Review and A Meta-Analysis
Prevalence of Dermatologic Side Effects of Mood Stabilizers in Bipolar Disorder: A Systematic Review and A Meta-Analysis Open
Introduction Bipolar disorder (BD) is a chronic illness affecting approximately 2-3% adults worldwide. Mood stabilizers, such as lithium, valproate, carbamazepine, and lamotrigine are mainstays of the treatment. Despite their benefits, moo…
View article: The DOE E3SM version 2.1: overview and assessment of the impacts of parameterized ocean submesoscales
The DOE E3SM version 2.1: overview and assessment of the impacts of parameterized ocean submesoscales Open
The U.S. Department of Energy's Energy Exascale Earth System Model (E3SM) version 2.1 builds on E3SMv2 with several changes, with the most notable being the addition of the Fox-Kemper et al. (2011) mixed-layer eddy parameterization. This p…
View article: WRF-ELM v1.0: a regional climate model to study land–atmosphere interactions over heterogeneous land use regions
WRF-ELM v1.0: a regional climate model to study land–atmosphere interactions over heterogeneous land use regions Open
The Energy Exascale Earth System Model (E3SM) Land Model (ELM) is a state-of-the-art land surface model that simulates the intricate interactions between the terrestrial land surface and other components of the Earth system. Originating fr…