Eeva Sliz
YOU?
Author Swipe
View article: 131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthma
131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthma Open
The coexistence of asthma and chronic rhinosinusitis with nasal polyposis (CRSwNP) is associated with allergic phenotypes, disease severity and failure of first-line treatment for both asthma and CRSwNP. Recent studies have highlighted sha…
View article: Genome-wide association meta-regression identifies stem cell lineage orchestration as a key driver of acne risk
Genome-wide association meta-regression identifies stem cell lineage orchestration as a key driver of acne risk Open
Over 85% of the population experience acne at some point in their lives, with its severity spanning a quantitative spectrum, from mild, transient outbreaks to more persistent, severe forms of the condition. Moderate to severe disease poses…
View article: O10 Acne polygenic risk score derived from genome-wide association metaregression enables prediction of severity
O10 Acne polygenic risk score derived from genome-wide association metaregression enables prediction of severity Open
Acne vulgaris is highly prevalent, with 85% of the population experiencing it at some point in their lives. Disease severity spans a quantitative spectrum, from mild, transient outbreaks to more persistent, severe forms of the condition. M…
View article: Role of oxysterol 4β-hydroxycholesterol and liver X receptor alleles in pre-eclampsia
Role of oxysterol 4β-hydroxycholesterol and liver X receptor alleles in pre-eclampsia Open
Our results demonstrate that plasma 4βHC and genetic LXR variants do not play a major role in PE and BP regulation during pregnancy. However, key LXR target genes involved in lipid metabolism were expressed differently in normal and PE pre…
View article: Exploring genetic risk factors for pneumonia using biobank resources - Insights across subpopulations
Exploring genetic risk factors for pneumonia using biobank resources - Insights across subpopulations Open
Background Pneumonia risk is influenced by demographics, chronic disease burden, lifestyle, and environmental factors. Despite genome-wide association studies (GWAS), the role of host genetics in pneumonia is still not fully understood, es…
View article: Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations
Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations Open
View article: Genetic risk factors underlying white matter hyperintensities and cortical atrophy
Genetic risk factors underlying white matter hyperintensities and cortical atrophy Open
White matter hyperintensities index structural abnormalities in the cerebral white matter, including axonal damage. The latter may promote atrophy of the cerebral cortex, a key feature of dementia. Here, we report a study of 51,065 individ…
View article: 131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthma
131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthma Open
The coexistence of asthma and chronic rhinosinusitis with nasal polyposis (CRSwNP) is associated with allergic phenotypes, disease severity and failure of first-line treatment for both asthma and CRSwNP. Recent studies have highlighted sha…
View article: Genome-wide association study indicates novel associations of annexin A13 to secretory and GAS2L2 with mucous otitis media
Genome-wide association study indicates novel associations of annexin A13 to secretory and GAS2L2 with mucous otitis media Open
To evaluate the genetics of chronic nonsuppurative otitis media (OM). We performed a genome-wide association study of 429,599 individuals included in the FinnGen study using three different case definitions: combined chronic nonsuppurative…
View article: Exploring metabolic changes in gout – Insights from a genetic study
Exploring metabolic changes in gout – Insights from a genetic study Open
Gout is the most common inflammatory joint disease caused by the crystallization of urate inside the joints. Patients with gout typically have abnormal blood lipid and sugar levels, which are associated with cardiovascular diseases. Howeve…
View article: Novel Genetic Variants Associated with Primary Myocardial Fibrosis in Sudden Cardiac Death Victims
Novel Genetic Variants Associated with Primary Myocardial Fibrosis in Sudden Cardiac Death Victims Open
View article: Genetic Study of Psoriasis Highlights its Close Link with Socioeconomic Status and Affective Symptoms
Genetic Study of Psoriasis Highlights its Close Link with Socioeconomic Status and Affective Symptoms Open
Psoriasis is an inflammatory skin disease with an estimated heritability of around 70%. Previous GWASs have detected several risk loci for psoriasis. To further improve the understanding of the genetic risk factors impacting the disease, w…
View article: Identifying Atopic Dermatitis Risk Loci in 1,094,060 Individuals with Subanalysis of Disease Severity and Onset
Identifying Atopic Dermatitis Risk Loci in 1,094,060 Individuals with Subanalysis of Disease Severity and Onset Open
Atopic dermatitis (AD) is a common inflammatory skin disease highly attributable to genetic factors. In this study, we report results from a genome-wide meta-analysis of AD in 37,541 cases and 1,056,519 controls with data from the FinnGen …
View article: Genome-Wide Association Study Reveals Novel Associations of Annexin A13 to Secretory and GAS2L2 with Mucous Otitis Media
Genome-Wide Association Study Reveals Novel Associations of Annexin A13 to Secretory and GAS2L2 with Mucous Otitis Media Open
Purpose: To evaluate the genetics of chronic non-suppurative otitis media (OM). Methods: We performed a genome-wide association study of 429,599 individuals included in the FinnGen study using three different case definitions: any type of …
View article: Genome-wide characterization of circulating metabolic biomarkers
Genome-wide characterization of circulating metabolic biomarkers Open
View article: Genome-wide association study of susceptibility to hospitalised respiratory infections
Genome-wide association study of susceptibility to hospitalised respiratory infections Open
Background: Globally, respiratory infections contribute to significant morbidity and mortality. However, genetic determinants of respiratory infections are understudied and remain poorly understood. Methods: We conducted a genome-wide asso…
View article: Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations
Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations Open
Introductory paragraph Given that lumbar disc herniation (LDH) is a prevalent spinal condition that causes significant individual suffering and societal costs 1 , the genetic basis of LDH has received relatively little research. Our aim wa…
View article: Low and high serum IgG associates with respiratory infections in a young and working age population
Low and high serum IgG associates with respiratory infections in a young and working age population Open
Oulu University Hospital VTR, CSL Behring, Foundation for Pediatric Research.
View article: Genetic study of psoriasis highlights its close link with socio-economic status and affective symptoms
Genetic study of psoriasis highlights its close link with socio-economic status and affective symptoms Open
Psoriasis is an inflammatory skin disease with an estimated heritability of around 70 %. Previous genome-wide association studies (GWASs) have detected several risk loci for psoriasis. To further improve the understanding of the genetic ri…
View article: The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions
The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions Open
View article: Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata
Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata Open
View article: Williams_et_al_extended_data
Williams_et_al_extended_data Open
These extended data documents relate to the manuscript titled " Genome-wide association study of susceptibility to hospitalised respiratory infections", which has been submitted to Wellcome Open Research, and include the following files: ·…
View article: Meta-analysis of atopic dermatitis in 1,094,060 individuals identifies new risk loci, and sub-analysis characterizes the loci with disease severity and onset
Meta-analysis of atopic dermatitis in 1,094,060 individuals identifies new risk loci, and sub-analysis characterizes the loci with disease severity and onset Open
Atopic dermatitis (AD) is a common inflammatory skin disease highly attributable to genetic factors. Here, we report results from a genome-wide meta-analysis of AD in 37,541 cases and 1,056,519 controls with data from the FinnGen project, …
View article: Genome-wide characterization of circulating metabolic biomarkers reveals substantial pleiotropy and novel disease pathways
Genome-wide characterization of circulating metabolic biomarkers reveals substantial pleiotropy and novel disease pathways Open
Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism 1–7 . This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal…
View article: Visceral adiposity is associated with metabolic profiles predictive of type 2 diabetes and myocardial infarction
Visceral adiposity is associated with metabolic profiles predictive of type 2 diabetes and myocardial infarction Open
View article: Circulating Metabolome and White Matter Hyperintensities in Women and Men
Circulating Metabolome and White Matter Hyperintensities in Women and Men Open
Background: White matter hyperintensities (WMH), identified on T2-weighted magnetic resonance images of the human brain as areas of enhanced brightness, are a major risk factor of stroke, dementia, and death. There are no large-scale studi…
View article: Leveraging Northern European population history: novel low-frequency variants for polycystic ovary syndrome
Leveraging Northern European population history: novel low-frequency variants for polycystic ovary syndrome Open
STUDY QUESTION Can we identify novel variants associated with polycystic ovary syndrome (PCOS) by leveraging the unique population history of Northern Europe? SUMMARY ANSWER We identified three novel genome-wide significant associations wi…
View article: Genome-wide association study of susceptibility to hospitalised respiratory infections
Genome-wide association study of susceptibility to hospitalised respiratory infections Open
Background: Globally, respiratory infections contribute to significant morbidity and mortality. However, genetic determinants of respiratory infections are understudied and remain poorly understood. Methods: We conducted a genome-wide asso…
View article: Uniting biobank resources reveals novel genetic pathways modulating susceptibility for atopic dermatitis
Uniting biobank resources reveals novel genetic pathways modulating susceptibility for atopic dermatitis Open
BackgroundAtopic dermatitis (AD) is a common chronic inflammatory skin disease with high heritability. Previous genome-wide association studies have identified several loci predisposing to AD. These findings explain approximately 30% of th…
View article: Evidence of a causal relationship between genetic tendency to gain muscle mass and uterine leiomyomata
Evidence of a causal relationship between genetic tendency to gain muscle mass and uterine leiomyomata Open
Uterine leiomyomata (UL) are the most common benign tumours of the female genital tract with an estimated lifetime incidence of up to 70% 1 . To date, 7 genome-wide association studies (GWASs) have identified 35 loci predisposing to UL. To…