Effi Haque
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View article: HNF1A POU Domain Mutations Found in Japanese Liver Cancer Patients Cause Downregulation of HNF4A Promoter Activity with Possible Disruption in Transcription Networks
HNF1A POU Domain Mutations Found in Japanese Liver Cancer Patients Cause Downregulation of HNF4A Promoter Activity with Possible Disruption in Transcription Networks Open
Hepatocyte nuclear factor 1A (HNF1A) is the master regulator of liver homeostasis and organogenesis and regulates many aspects of hepatocyte functions. It acts as a tumor suppressor in the liver, evidenced by the increased proliferation in…
View article: Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver
Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver Open
The hepatocyte nuclear factor-4α (HNF4α) and hepatocyte nuclear factor-1α (HNF1α) are transcription factors that influence the development and maintenance of homeostasis in a variety of tissues, including the liver. As such, disruptions in…
View article: NRF2 DLG Domain Mutations Identified in Japanese Liver Cancer Patients Affect the Transcriptional Activity in HCC Cell Lines
NRF2 DLG Domain Mutations Identified in Japanese Liver Cancer Patients Affect the Transcriptional Activity in HCC Cell Lines Open
Geographically, East Asia had the highest liver cancer burden in 2017. Besides this, liver cancer-related deaths were high in Japan, accounting for 3.90% of total deaths. The development of liver cancer is influenced by several factors, an…
View article: Xanthohumol for Human Malignancies: Chemistry, Pharmacokinetics and Molecular Targets
Xanthohumol for Human Malignancies: Chemistry, Pharmacokinetics and Molecular Targets Open
Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. (Hop plant). XH is an important ingredient in beer and is considered a significant bioactive agent due to its diverse medici…
View article: Deletion of the Prdm3 Gene Causes a Neuronal Differentiation Deficiency in P19 Cells
Deletion of the Prdm3 Gene Causes a Neuronal Differentiation Deficiency in P19 Cells Open
PRDM (PRDI-BF1 (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1) homologous domain-containing) transcription factors are a group of proteins that have a significant impact on o…
View article: Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis
Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis Open
NF-E2-related factor 2 (NRF2) is a basic leucine zipper transcription factor, a master regulator of redox homeostasis regulating a variety of genes for antioxidant and detoxification enzymes. NRF2 was, therefore, initially thought to prote…
View article: Application of CRISPR/Cas9 Genome Editing Technology for the Improvement of Crops Cultivated in Tropical Climates: Recent Progress, Prospects, and Challenges
Application of CRISPR/Cas9 Genome Editing Technology for the Improvement of Crops Cultivated in Tropical Climates: Recent Progress, Prospects, and Challenges Open
The world population is expected to increase from 7.3 to 9.7 billion by 2050. Pest outbreak and increased abiotic stresses due to climate change pose a high risk to tropical crop production. Although conventional breeding techniques have s…
View article: Endophytic <i>Bacillus</i> spp. from medicinal plants inhibit mycelial growth of <i>Sclerotinia sclerotiorum</i> and promote plant growth
Endophytic <i>Bacillus</i> spp. from medicinal plants inhibit mycelial growth of <i>Sclerotinia sclerotiorum</i> and promote plant growth Open
Plant growth-promoting bacteria that are also capable of suppressing plant pathogenic fungi play an important role in sustainable agriculture. There is a critical need for conducting research to discover, characterize and evaluate the effi…
View article: Enhancement of Growth and Grain Yield of Rice in Nutrient Deficient Soils by Rice Probiotic Bacteria
Enhancement of Growth and Grain Yield of Rice in Nutrient Deficient Soils by Rice Probiotic Bacteria Open
Plant associated bacteria are promising alternatives to chemical fertilizers for plant growth and yield improvement in an eco-friendly manner. In this study, rice associated bacteria were isolated and assessed for mineral phosphate solubil…
View article: Medicinal plant extracts and protein kinase C inhibitor suppress zoosporogenesis and impair motility of Phytophthora capsici zoospores
Medicinal plant extracts and protein kinase C inhibitor suppress zoosporogenesis and impair motility of Phytophthora capsici zoospores Open
The effects of water and acetone extracts from 100 medicinal plants growing in Bangladesh, along with a selective inhibitor of protein kinase C (PKC), chelerythrine chloride, were tested on zoosporogenesis (release of zoospores from the sp…