Anastasia Efimenko
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View article: Safety and Regenerative Properties of Immortalized Human Mesenchymal Stromal Cell Secretome
Safety and Regenerative Properties of Immortalized Human Mesenchymal Stromal Cell Secretome Open
The secretome of mesenchymal stromal cells (MSCs) can efficiently stimulate regeneration and therefore is a tempting remedy for “cell-free cellular therapy”. However, the usage of primary MSC cultures as secretome producers for translation…
View article: The regulatory clinical trial has commenced for “MediReg”®, an original domestically developed biologic drug based on the secretome of human mesenchymal stromal cells
The regulatory clinical trial has commenced for “MediReg”®, an original domestically developed biologic drug based on the secretome of human mesenchymal stromal cells Open
Throughout life, the cellular components of tissues and organs require timely renewal and repair following significant damage. This function is carried out by stem cells, which in adult organisms are regulated by a specialized microenviron…
View article: Evaluation of the effects of quercetin and dihydroquercetin on cellular behavior and biomarkers of senescence in mesenchymal stem/stromal cells obtained from elderly patients
Evaluation of the effects of quercetin and dihydroquercetin on cellular behavior and biomarkers of senescence in mesenchymal stem/stromal cells obtained from elderly patients Open
BACKGROUND: The accumulation of senescent cells in human tissues and organs leads to a decrease in the ability of tissues to renew and function normally, which affects the aging of the organism as a whole and contributes to the development…
View article: Stem Cell Niche Concept: Search for Current Expert Consensus
Stem Cell Niche Concept: Search for Current Expert Consensus Open
Postnatal stem cells are crucial for tissue homeostasis and repair and are regulated by specialized microenvironmental microterritories known as “stem cell niches”. Proposed by R. Schofield in 1978 for hematopoietic stem cells, niches main…
View article: In vitro models for biological activity evaluation of a new antifibrotic drug based on the vesicular fraction of the human mesenchymal stromal cells secretome
In vitro models for biological activity evaluation of a new antifibrotic drug based on the vesicular fraction of the human mesenchymal stromal cells secretome Open
Introduction. The vesicular fraction of human mesenchymal stem/stromal cells (EV MSCs) secretome can be considered as a pharmaceutical substance for the biological drug development to treat fibrotic diseases. Biological drugs quality contr…
View article: Extracellular Vesicles of Adipose Multipotent Mesenchymal Stromal Cells Propagate Senescent Phenotype by Affecting PTEN Nuclear Import
Extracellular Vesicles of Adipose Multipotent Mesenchymal Stromal Cells Propagate Senescent Phenotype by Affecting PTEN Nuclear Import Open
Replicative or stress-induced senescence disrupts the functioning of multipotent mesenchymal stromal cells (MSCs) required for tissue renewal and regeneration. Aged MSCs demonstrate reduced proliferation, impaired differentiation, and aber…
View article: Overexpression of BDNF and uPA Combined with the Suppression of Von Hippel–Lindau Tumor Suppressor Enhances the Neuroprotective Activity of the Secretome of Human Mesenchymal Stromal Cells in the Model of Intracerebral Hemorrhage
Overexpression of BDNF and uPA Combined with the Suppression of Von Hippel–Lindau Tumor Suppressor Enhances the Neuroprotective Activity of the Secretome of Human Mesenchymal Stromal Cells in the Model of Intracerebral Hemorrhage Open
Nerve tissue damage is an unsolved problem in modern neurology and neurosurgery, which prompts the need to search for approaches to stimulate neuroprotection and regeneration of neural tissue. Earlier we have shown that the secretome of hu…
View article: Programmed cell death and tissue regeneration: a link that should be resolved
Programmed cell death and tissue regeneration: a link that should be resolved Open
Cellular homeostasis is maintained by three important physiological processes: proliferation, characterized by an increase in cell number; differentiation, characterized by either an increase or a decrease in cell number coincident with ch…
View article: The effect of dihydroquercetin therapy on clinical status and the burden of senescent cells in elderly patients with chronic heart failure: rationale and study design
The effect of dihydroquercetin therapy on clinical status and the burden of senescent cells in elderly patients with chronic heart failure: rationale and study design Open
RELEVANCE. Chronic heart failure (CHF) is an age-related disease affecting approximately 63 million people worldwide. In Russia, the prevalence of CHF has increased from 6.1 % to 8.2 % over the past 20 years, with most experts attributing …
View article: The Role of Macrophages in Implementing the Effects of Secretome of Mesenchymal Stromal Cells in the Spermatogonial Stem Cell Niche
The Role of Macrophages in Implementing the Effects of Secretome of Mesenchymal Stromal Cells in the Spermatogonial Stem Cell Niche Open
Our findings indicate the impact of the damage etiology and pathogenesis on the involvement of M2 macrophages in the implementation of the MSC secretome effects and the absence of its systemic immunotoxicity.
View article: Experimental evaluation of CA3(PO4)2 based bone substitutes using rat femoral defect models
Experimental evaluation of CA3(PO4)2 based bone substitutes using rat femoral defect models Open
Introduction Replacement of bone defects is an important issue of modern traumatology and orthopedics. With increasing technological advances there is a spectrum of bone-substituting materials, and the choice of the effective option is ess…
View article: Creation and characterization of human mesenchymal stromal cell cultures with prolonged proliferative potential for the tasks of regenerative medicine
Creation and characterization of human mesenchymal stromal cell cultures with prolonged proliferative potential for the tasks of regenerative medicine Open
The study of molecular mechanisms of regeneration requires convenient models for in vitro and in vivo studies. In vitro cell cultures can fulfill such a function. However, their rapid aging and loss of initial specific properties in cultur…
View article: Tissue-specific expression and alternative splicing of fibroblast activation protein alpha (FAPα) gene in human stromal cells
Tissue-specific expression and alternative splicing of fibroblast activation protein alpha (FAPα) gene in human stromal cells Open
BACKGROUND: Activated stromal cells, responsible for tissue repair and restoration of tissue integrity, play an important role in tissue response to damage. The key marker of activated stromal cells is the fibroblast activation protein α (…
View article: Safety Profile Evaluation of an Original Mesenchymal Stromal Cell Secretome-Based Medicinal Product after Intratesticular Injection in Rabbits
Safety Profile Evaluation of an Original Mesenchymal Stromal Cell Secretome-Based Medicinal Product after Intratesticular Injection in Rabbits Open
INTRODUCTION. This work is a continuation of the studies of an original biological product based on the secretome of human mesenchymal stromal cells (MSCs) and intended for the restoration of spermatogenesis and fertility. To ensure the sa…
View article: Features of forming trust in communication with elderly and senile patients
Features of forming trust in communication with elderly and senile patients Open
BACKGROUND . Methods for slowing down aging processes and progressing of age-associated diseases are being extensively studied. To make significant discoveries in this area, scientists need data on elderly patients, primarily as the target…
View article: The Role of Activated Stromal Cells in Fibrotic Foci Formation and Reversion
The Role of Activated Stromal Cells in Fibrotic Foci Formation and Reversion Open
Fibrotic focus is a pivotal morphofunctional unit in developing fibrosis in various tissues. For most fibrotic diseases, including progressive forms, the foci are considered unable to remodel and contribute to the worsening of prognosis. U…
View article: The Effect of Long-Term Physical Disability and Aging on Extracellular Matrix Biogenesis in Human Skeletal Muscle
The Effect of Long-Term Physical Disability and Aging on Extracellular Matrix Biogenesis in Human Skeletal Muscle Open
Physical inactivity and aging cause significant impairments in the functionality and mechanical properties of skeletal muscles, as well as remodeling of the extracellular matrix (ECM). We aimed to study the effect of long-term inactivity a…
View article: Development program of the scientific journal “Tissue and organ regeneration”
Development program of the scientific journal “Tissue and organ regeneration” Open
The article describes the prerequisites and experience of creation, as well as the current stage of development of the new scientific journal “Tissue and Organ Regeneration”, determines its place in the publication landscape in Russia, jus…
View article: Modern approaches to the creation of 2D and 3D cellular models for the study of lung fibrosis
Modern approaches to the creation of 2D and 3D cellular models for the study of lung fibrosis Open
Lung fibrosis is a consequence of many influences leading to damage to lung tissue and the development of subsequent inflammation. Fibrosis is an overgrowth of connective tissue, which can lead to a violation of the architectonics of the l…
View article: Age‐related changes in human skeletal muscle transcriptome and proteome are more affected by chronic inflammation and physical inactivity than primary aging
Age‐related changes in human skeletal muscle transcriptome and proteome are more affected by chronic inflammation and physical inactivity than primary aging Open
Evaluation of the influence of primary and secondary aging on the manifestation of molecular and cellular hallmarks of aging is a challenging and currently unresolved issue. Our study represents the first demonstration of the distinct role…
View article: Novel Immortalized Human Multipotent Mesenchymal Stromal Cell Line for Studying Hormonal Signaling
Novel Immortalized Human Multipotent Mesenchymal Stromal Cell Line for Studying Hormonal Signaling Open
Multipotent mesenchymal stromal cells (MSCs) integrate hormone and neuromediator signaling to coordinate tissue homeostasis, tissue renewal and regeneration. To facilitate the investigation of MSC biology, stable immortalized cell lines ar…
View article: Balance between Pro- and Antifibrotic Proteins in Mesenchymal Stromal Cell Secretome Fractions Revealed by Proteome and Cell Subpopulation Analysis
Balance between Pro- and Antifibrotic Proteins in Mesenchymal Stromal Cell Secretome Fractions Revealed by Proteome and Cell Subpopulation Analysis Open
Multipotent mesenchymal stromal cells (MSCs) regulate tissue repair through paracrine activity, with secreted proteins being significant contributors. Human tissue repair commonly results in fibrosis, where fibroblast differentiation into …
View article: Modeling the profibrotic microenvironment<i>in vitro</i>: model validation
Modeling the profibrotic microenvironment<i>in vitro</i>: model validation Open
Establishing the molecular and cellular mechanisms of fibrosis requires the development of validated and reproducible models. The complexity of in vivo models challenges the monitoring of an individual cell fate, in some cases making it im…
View article: Age-related changes in human skeletal muscle transcriptome and proteome are more affected by chronic inflammation and physical inactivity than primary aging
Age-related changes in human skeletal muscle transcriptome and proteome are more affected by chronic inflammation and physical inactivity than primary aging Open
Evaluation of the influence of primary and secondary aging on the manifestation of molecular and cellular hallmarks of aging is a challenging and currently unresolved issue. Our study represents the first demonstration of the distinct role…
View article: M2-Macrophage-Induced Chronic Inflammation Promotes Reversible Mesenchymal Stromal Cell Senescence and Reduces Their Anti-Fibrotic Properties
M2-Macrophage-Induced Chronic Inflammation Promotes Reversible Mesenchymal Stromal Cell Senescence and Reduces Their Anti-Fibrotic Properties Open
Fibrosis and the associated decline in organ functionality lead to an almost 50% mortality rate in developed countries. Multipotent mesenchymal stromal cells (MSC) were shown to suppress the development and progression of fibrosis through …
View article: Fibroblast Activation Protein Alpha (FAPα) in Fibrosis: Beyond a Perspective Marker for Activated Stromal Cells?
Fibroblast Activation Protein Alpha (FAPα) in Fibrosis: Beyond a Perspective Marker for Activated Stromal Cells? Open
The development of tissue fibrosis is a complex process involving the interaction of multiple cell types, which makes the search for antifibrotic agents rather challenging. So far, myofibroblasts have been considered the key cell type that…
View article: Extracellular matrix-induced signaling pathways in mesenchymal stem/stromal cells
Extracellular matrix-induced signaling pathways in mesenchymal stem/stromal cells Open
The extracellular matrix (ECM) is a crucial component of the stem cell microenvironment, or stem-cell niches, and contributes to the regulation of cell behavior and fate. Accumulating evidence indicates that different types of stem cells p…
View article: Safety Study of an Original Mesenchymal Stromal Cell Secretome-Based Medicinal Product for Spermatogenesis Restoration
Safety Study of an Original Mesenchymal Stromal Cell Secretome-Based Medicinal Product for Spermatogenesis Restoration Open
SCIENTIFIC RELEVANCE. Currently, there are no effective and safe medicinal products for idiopathic male infertility. Previous studies in two animal models of infertility (short-term cryptorchidism in rats and doxorubicin-induced testicular…