Efrat Edry
YOU?
Author Swipe
View article: Virally mediated expression of a biologically active peptide to restrain the nuclear functions of ERK1/2 attenuates learning extinction but not acquisition
Virally mediated expression of a biologically active peptide to restrain the nuclear functions of ERK1/2 attenuates learning extinction but not acquisition Open
Peptide drug technologies offer powerful approaches to develop potent and selective lead molecules for therapeutic and research applications. However, new and optimized delivery approaches are necessary to overcome current pitfalls includi…
View article: Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer’s disease phenotype in mice
Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer’s disease phenotype in mice Open
Biological aging can be described as accumulative, prolonged metabolic stress and is the major risk factor for cognitive decline and Alzheimer's disease (AD). Recently, we identified and described a quinone reductase 2 (QR2) pathway in the…
View article: Somatostatin Interneurons of the Insula Mediate QR2-Dependent Novel Taste Memory Enhancement
Somatostatin Interneurons of the Insula Mediate QR2-Dependent Novel Taste Memory Enhancement Open
Forming long-term memories is crucial for adaptive behavior and survival in changing environments. The molecular consolidation processes which underlie the formation of these long-term memories are dependent on protein synthesis in excitat…
View article: Dopamine-Dependent QR2 Pathway Activation in CA1 Interneurons Enhances Novel Memory Formation
Dopamine-Dependent QR2 Pathway Activation in CA1 Interneurons Enhances Novel Memory Formation Open
The formation of memory for a novel experience is a critical cognitive capacity. The ability to form novel memories is sensitive to age-related pathologies and disease, to which prolonged metabolic stress is a major contributing factor. Pr…
View article: Muscarinic-Dependent miR-182 and QR2 Expression Regulation in the Anterior Insula Enables Novel Taste Learning
Muscarinic-Dependent miR-182 and QR2 Expression Regulation in the Anterior Insula Enables Novel Taste Learning Open
In a similar manner to other learning paradigms, intact muscarinic acetylcholine receptor (mAChR) neurotransmission or protein synthesis regulation in the anterior insular cortex (aIC) is necessary for appetitive taste learning. Here we de…
View article: Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties
Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties Open
Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of four known kinases that respond to cellular stress by deactivating the eukaryotic initiation factor 2 α (eIF2α) or other signal transduction cascades. Recently, both…
View article: Additional file 3: of Fluid consumption and taste novelty determines transcription temporal dynamics in the gustatory cortex
Additional file 3: of Fluid consumption and taste novelty determines transcription temporal dynamics in the gustatory cortex Open
ANOVA differential expression. The influence of time (1,3 hrs), treatment (novel saccharin, water) and the interaction between the two on mRNA expression in the GC. (XLSX 31 kb)
View article: Additional file 2: of Fluid consumption and taste novelty determines transcription temporal dynamics in the gustatory cortex
Additional file 2: of Fluid consumption and taste novelty determines transcription temporal dynamics in the gustatory cortex Open
Expression of mRNAs in the GC. Novel saccharin compared to water group, between and within group comparison at 1 and 3 hrs. (XLSX 39 kb)